Benoit Bruneau, PhD

Professor
Department of Pediatrics
+1 415 734-2708

The main focus of our lab is to understand how a heart becomes a heart: what cell lineage decisions take place to direct cardiac differentiation, and what morphogenetic and patterning processes occur to assemble all of the heart's components into a functional organ. We are primarily interested in regulation of these processes by transcriptional regulatory mechanisms that include DNA-binding transcription factors, chromatin remodeling complexes, and histone modifications. We have used this knowledge to understand disease mechanisms, but also to devise strategies for cardiac regeneration.

Why study heart development? We believe that primary defects in patterning in early heart development are at the root of congenital heart defects, which affect approximately 1% of live-born children, and we want to understand how these defects occur, to perhaps be able to uncover new and improved diagnostic or even therapeutic options. Also, by understanding how cardiac lineage specification occurs, we can better design stem cell-based interventions of cardiac repair, based on the knowledge of what drives an uncommitted cell towards a specific cardiac fate. We have recently focused our efforts on cardiac chromatin remodeling and modification factors, enzymes that unwind DNA or modify histones to turn genes on or off. We are particularly interested in how these factors control cardiac cell lineage decisions. These chromatin remodeling factors may also be key to pushing a stem cell into becoming a heart cell, perhaps opening up new avenues for cardiac regenerative medicine.

Research Summary: 
Transcriptional regulation of cardiac morphogenesis and differentiation
Publications: 

Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization.

Cell

Nora EP, Goloborodko A, Valton AL, Gibcus JH, Uebersohn A, Abdennur N, Dekker J, Mirny LA, Bruneau BG

Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites.

Development (Cambridge, England)

Anderson CM, Hu J, Thomas R, Gainous TB, Celona B, Sinha T, Dickel DE, Heidt AB, Xu SM, Bruneau BG, Pollard KS, Pennacchio LA, Black BL

Single-Cell Resolution of Temporal Gene Expression during Heart Development.

Developmental cell

DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE

ATP-dependent chromatin remodeling during mammalian development.

Development (Cambridge, England)

Hota SK, Bruneau BG

Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization.

Bone reports

Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau BG, Hsiao EC

Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.

Cell stem cell

Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S

KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation.

Development (Cambridge, England)

Ang SY, Uebersohn A, Spencer CI, Huang Y, Lee JE, Ge K, Bruneau BG

Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.

Cell

Luna-Zurita L, Stirnimann CU, Glatt S, Kaynak BL, Thomas S, Baudin F, Samee MA, He D, Small EM, Mileikovsky M, Nagy A, Holloway AK, Pollard KS, Müller CW, Bruneau BG

Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor.

Molecular biology and evolution

Holloway AK, Bruneau BG, Sukonnik T, Rubenstein JL, Pollard KS

Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms.

Cell stem cell

Morey L, Santanach A, Blanco E, Aloia L, Nora EP, Bruneau BG, Di Croce L

Brg1 modulates enhancer activation in mesoderm lineage commitment.

Development (Cambridge, England)

Alexander JM, Hota SK, He D, Thomas S, Ho L, Pennacchio LA, Bruneau BG

Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency.

Cell

Theodoris CV, Li M, White MP, Liu L, He D, Pollard KS, Bruneau BG, Srivastava D

Evolution of lysine acetylation in the RNA polymerase II C-terminal domain.

BMC evolutionary biology

Simonti CN, Pollard KS, Schröder S, He D, Bruneau BG, Ott M, Capra JA

Investigating the transcriptional control of cardiovascular development.

Circulation research

Kathiriya IS, Nora EP, Bruneau BG

Looking inwards: opening a window onto human development.

Development (Cambridge, England)

Pourquié O, Bruneau B, Keller G, Smith A

Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature.

Development (Cambridge, England)

Delgado-Olguín P, Dang LT, He D, Thomas S, Chi L, Sukonnik T, Khyzha N, Dobenecker MW, Fish JE, Bruneau BG

Early patterning and specification of cardiac progenitors in gastrulating mesoderm.

eLife

Devine WP, Wythe JD, George M, Koshiba-Takeuchi K, Bruneau BG

HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles.

Genes & development

Saccone V, Consalvi S, Giordani L, Mozzetta C, Barozzi I, Sandoná M, Ryan T, Rojas-Muñoz A, Madaro L, Fasanaro P, Borsellino G, De Bardi M, Frigè G, Termanini A, Sun X, Rossant J, Bruneau BG, Mercola M, Minucci S, Puri PL

Function-based identification of mammalian enhancers using site-specific integration.

Nature methods

Dickel DE, Zhu Y, Nord AS, Wylie JN, Akiyama JA, Afzal V, Plajzer-Frick I, Kirkpatrick A, Göttgens B, Bruneau BG, Visel A, Pennacchio LA

Congenital heart disease: entering a new era of human genetics.

Circulation research

Bruneau BG, Srivastava D

Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells.

Molecular cell

Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M

An interview with Benoit Bruneau.

Development (Cambridge, England)

Bruneau B

Chromatin modulators as facilitating factors in cellular reprogramming.

Current opinion in genetics & development

Luna-Zurita L, Bruneau BG

Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state.

Stem cell reports

Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D

ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.

PLoS genetics

Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL

ETS factors regulate Vegf-dependent arterial specification.

Developmental cell

Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau BG, Fish JE

Stem cells and regeneration: a special issue.

Development (Cambridge, England)

Pourquié O, Bruneau B, Götz M, Keller G, Smith A

The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage.

Genome biology

Shaffer HB, Minx P, Warren DE, Shedlock AM, Thomson RC, Valenzuela N, Abramyan J, Amemiya CT, Badenhorst D, Biggar KK, Borchert GM, Botka CW, Bowden RM, Braun EL, Bronikowski AM, Bruneau BG, Buck LT, Capel B, Castoe TA, Czerwinski M, Delehaunty KD, Edwards SV, Fronick CC, Fujita MK, Fulton L, Graves TA, Green RE, Haerty W, Hariharan R, Hernandez O, Hillier LW, Holloway AK, Janes D, Janzen FJ, Kandoth C, Kong L, de Koning AP, Li Y, Literman R, McGaugh SE, Mork L, O'Laughlin M, Paitz RT, Pollock DD, Ponting CP, Radhakrishnan S, Raney BJ, Richman JM, St John J, Schwartz T, Sethuraman A, Spinks PQ, Storey KB, Thane N, Vinar T, Zimmerman LM, Warren WC, Mardis ER, Wilson RK

Signaling and transcriptional networks in heart development and regeneration.

Cold Spring Harbor perspectives in biology

Bruneau BG

Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6.

Development (Cambridge, England)

Star EN, Zhu M, Shi Z, Liu H, Pashmforoush M, Sauve Y, Bruneau BG, Chow RL

Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology.

Development (Cambridge, England)

Gaborit N, Sakuma R, Wylie JN, Kim KH, Zhang SS, Hui CC, Bruneau BG

Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage.

Cell

Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA, Erwin G, Kattman SJ, Keller GM, Srivastava D, Levine SS, Pollard KS, Holloway AK, Boyer LA, Bruneau BG

Iroquois homeodomain transcription factors in heart development and function.

Circulation research

Kim KH, Rosen A, Bruneau BG, Hui CC, Backx PH

Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.

Nature genetics

Delgado-Olguín P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG

Epigenetics and cardiovascular development.

Annual review of physiology

Chang CP, Bruneau BG

Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network.

Proceedings of the National Academy of Sciences of the United States of America

Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olguín P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DY, Shaw RM, Hui CC, Bruneau BG, Backx PH

Atrial natriuretic factor in the developing heart: a signpost for cardiac morphogenesis.

Canadian journal of physiology and pharmacology

Bruneau BG

Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb.

Development (Cambridge, England)

Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau BG, Hopyan S

Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.

The Journal of cell biology

Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R

A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish.

Development (Cambridge, England)

Fish JE, Wythe JD, Xiao T, Bruneau BG, Stainier DY, Srivastava D, Woo S

Chromatin remodelling complex dosage modulates transcription factor function in heart development.

Nature communications

Takeuchi JK, Lou X, Alexander JM, Sugizaki H, Delgado-Olguín P, Holloway AK, Mori AD, Wylie JN, Munson C, Zhu Y, Zhou YQ, Yeh RF, Henkelman RM, Harvey RP, Metzger D, Chambon P, Stainier DY, Pollard KS, Scott IC, Bruneau BG

CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors.

The Journal of biological chemistry

Delgado-Olguín P, Brand-Arzamendi K, Scott IC, Jungblut B, Stainier DY, Bruneau BG, Recillas-Targa F

An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation.

Proceedings of the National Academy of Sciences of the United States of America

Nadeau M, Georges RO, Laforest B, Yamak A, Lefebvre C, Beauregard J, Paradis P, Bruneau BG, Andelfinger G, Nemer M

Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart.

Human molecular genetics

Puskaric S, Schmitteckert S, Mori AD, Glaser A, Schneider KU, Bruneau BG, Blaschke RJ, Steinbeisser H, Rappold G

Chromatin remodeling in heart development.

Current opinion in genetics & development

Bruneau BG

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.

Cell

Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D

Lessons for cardiac regeneration and repair through development.

Trends in molecular medicine

Alexander JM, Bruneau BG

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.

Human molecular genetics

Kuo YM, Li Z, Jiao Y, Gaborit N, Pani AK, Orrison BM, Bruneau BG, Giasson BI, Smeyne RJ, Gershon MD, Nussbaum RL

The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.

The Journal of biological chemistry

Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D

Reptilian heart development and the molecular basis of cardiac chamber evolution.

Nature

Koshiba-Takeuchi K, Mori AD, Kaynak BL, Cebra-Thomas J, Sukonnik T, Georges RO, Latham S, Beck L, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SF, Bruneau BG

NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes.

PloS one

Riazi AM, Takeuchi JK, Hornberger LK, Zaidi SH, Amini F, Coles J, Bruneau BG, Van Arsdell GS

Alternative induced pluripotent stem cell characterization criteria for in vitro applications.

Cell stem cell

Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL

miR-126 regulates angiogenic signaling and vascular integrity.

Developmental cell

Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D

Tbx5-dependent pathway regulating diastolic function in congenital heart disease.

Proceedings of the National Academy of Sciences of the United States of America

Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Henkelman RM, Backx PH, Redington AN, Maclennan DH, Bruneau BG

4D cardiac MRI in the mouse.

NMR in biomedicine

Feintuch A, Zhu Y, Bishop J, Davidson L, Dazai J, Bruneau BG, Henkelman RM

The heart's Da Vinci code: a Renaissance at Keystone.

Development (Cambridge, England)

Bruneau BG, Black BL

Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.

Proceedings of the National Academy of Sciences of the United States of America

Takeuchi JK, Lickert H, Bisgrove BW, Sun X, Yamamoto M, Chawengsaksophak K, Hamada H, Yost HJ, Rossant J, Bruneau BG

Irxl1, a divergent Iroquois homeobox family transcription factor gene.

Gene expression patterns : GEP

Takeuchi JK, Bruneau BG

Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.

Developmental biology

Mori AD, Zhu Y, Vahora I, Nieman B, Koshiba-Takeuchi K, Davidson L, Pizard A, Seidman JG, Seidman CE, Chen XJ, Henkelman RM, Bruneau BG

Chromatin modification and remodeling in heart development.

TheScientificWorldJournal

Delgado-Olguín P, Takeuchi JK, Bruneau BG

Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.

Nature genetics

Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG

The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.

Cell

Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau BG

A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia.

Development (Cambridge, England)

Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau BG, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J

The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development.

Developmental biology

Cheng CW, Chow RL, Lebel M, Sakuma R, Cheung HO, Thanabalasingham V, Zhang X, Bruneau BG, Birch DG, Hui CC, McInnes RR, Cheng SH

Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs.

Nature genetics

Frey BJ, Mohammad N, Morris QD, Zhang W, Robinson MD, Mnaimneh S, Chang R, Pan Q, Sat E, Rossant J, Bruneau BG, Aubin JE, Blencowe BJ, Hughes TR

Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.

Molecular and cellular biology

Pizard A, Burgon PG, Paul DL, Bruneau BG, Seidman CE, Seidman JG

Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndrome.

American journal of physiology. Heart and circulatory physiology

Zhou YQ, Zhu Y, Bishop J, Davidson L, Henkelman RM, Bruneau BG, Foster FS

Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development.

Development (Cambridge, England)

Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG

Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes.

The Journal of biological chemistry

Barron MR, Belaguli NS, Zhang SX, Trinh M, Iyer D, Merlo X, Lough JW, Parmacek MS, Bruneau BG, Schwartz RJ

Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.

Nature

Lickert H, Takeuchi JK, Von Both I, Walls JR, McAuliffe F, Adamson SL, Henkelman RM, Wrana JL, Rossant J, Bruneau BG

Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.

The EMBO journal

McPherson JP, Tamblyn L, Elia A, Migon E, Shehabeldin A, Matysiak-Zablocki E, Lemmers B, Salmena L, Hakem A, Fish J, Kassam F, Squire J, Bruneau BG, Hande MP, Hakem R

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.

Development (Cambridge, England)

Moskowitz IP, Pizard A, Patel VV, Bruneau BG, Kim JB, Kupershmidt S, Roden D, Berul CI, Seidman CE, Seidman JG

Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract.

Development (Cambridge, England)

Xu H, Morishima M, Wylie JN, Schwartz RJ, Bruneau BG, Lindsay EA, Baldini A

TBX5 mutations and congenital heart disease: Holt-Oram syndrome revealed.

Current opinion in cardiology

Mori AD, Bruneau BG

The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice.

Molecular and cellular biology

Lebel M, Agarwal P, Cheng CW, Kabir MG, Chan TY, Thanabalasingham V, Zhang X, Cohen DR, Husain M, Cheng SH, Bruneau BG, Hui CC

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart.

Developmental biology

Stennard FA, Costa MW, Elliott DA, Rankin S, Haast SJ, Lai D, McDonald LP, Niederreither K, Dolle P, Bruneau BG, Zorn AM, Harvey RP

Tbx5 is required for forelimb bud formation and continued outgrowth.

Development (Cambridge, England)

Rallis C, Bruneau BG, Del Buono J, Seidman CE, Seidman JG, Nissim S, Tabin CJ, Logan MP

Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo.

Development (Cambridge, England)

Agarwal P, Wylie JN, Galceran J, Arkhitko O, Li C, Deng C, Grosschedl R, Bruneau BG

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.

Cell

Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG

Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.

Molecular and cellular biology

Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG

Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand.

Developmental biology

Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE

Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome.

Developmental biology

Bruneau BG, Logan M, Davis N, Levi T, Tabin CJ, Seidman JG, Seidman CE

Characterization of natriuretic peptide production by adult heart atria.

The American journal of physiology

Ogawa T, Vatta M, Bruneau BG, de Bold AJ

Regulation of chamber-specific gene expression in the developing heart by Irx4.

Science (New York, N.Y.)

Bao ZZ, Bruneau BG, Seidman JG, Seidman CE, Cepko CL

BNP gene expression is specifically modulated by stretch and ET-1 in a new model of isolated rat atria.

The American journal of physiology

Bruneau BG, Piazza LA, de Bold AJ

Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome.

Nature genetics

Bamshad M, Lin RC, Law DJ, Watkins WC, Krakowiak PA, Moore ME, Franceschini P, Lala R, Holmes LB, Gebuhr TC, Bruneau BG, Schinzel A, Seidman JG, Seidman CE, Jorde LB

Evidence for load-dependent and load-independent determinants of cardiac natriuretic peptide production.

Circulation

Ogawa T, Linz W, Stevenson M, Bruneau BG, Kuroski de Bold ML, Chen JH, Eid H, Schölkens BA, de Bold AJ

Dissociation of cardiac hypertrophy, myosin heavy chain isoform expression, and natriuretic peptide production in DOCA-salt rats.

American journal of hypertension

Yokota N, Bruneau BG, Fernandez BE, de Bold ML, Piazza LA, Eid H, de Bold AJ