Todd Mcdevitt, PhD

Senior Investigator, Gladstone Institute
Professor
Department of Bioengineering and Therapeutic Sciences
+1 415 734-2875

Dr. McDevitt is a Senior Investigator at the Gladstone Institute of Cardiovascular Disease and a Professor of Bioengineering and Therapeutics at the University of California, San Francisco. He was previously the founding Director of the Stem Cell Engineering Center at Georgia Tech, the Carol Ann and David D. Flanagan Professor in the Wallace H. Coulter Department of Biomedical Engineering, and a Petit Faculty Fellow in the Parker H. Petit Institute for Bioengineering and Bioscience. Dr. McDevitt has 18 years of experience in biomaterials and tissue engineering research and for the past 14 years has focused primarily on stem cell biology and engineering. One of the primary objectives of Dr. McDevitt’s research is to engineer tissues, largely from stem cell sources, for regenerative medicine and in vitro diagnostic applications. Much of the research in the McDevitt laboratory focuses on the application of microtechnologies to engineer 3D environments in order to more effectively control multicellular organization that better recapitulates complex tissue structure and subsequent function.

Publications: 

Phenotypic Variation Between Stromal Cells Differentially Impacts Engineered Cardiac Tissue Function.

Tissue engineering. Part A

Hookway TA, Matthys OB, Mendoza-Camacho FN, Rains S, Sepulveda JE, Joy DA, McDevitt TC

Comparable Decellularization of Fetal and Adult Cardiac Tissue Explants as 3D-like Platforms for In Vitro Studies.

Journal of visualized experiments : JoVE

Silva AC, Oliveira MJ, McDevitt TC, Barbosa MA, Nascimento DS, Pinto-do-Ó P

Perspective: The promise of multi-cellular engineered living systems.

APL bioengineering

Kamm RD, Bashir R, Arora N, Dar RD, Gillette MU, Griffith LG, Kemp ML, Kinlaw K, Levin M, Martin AC, McDevitt TC, Nerem RM, Powers MJ, Saif TA, Sharpe J, Takayama S, Takeuchi S, Weiss R, Ye K, Yevick HG, Zaman MH

Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.

eLife

Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC

A rapid method for determining protein diffusion through hydrogels for regenerative medicine applications.

APL bioengineering

Hettiaratchi MH, Schudel A, Rouse T, García AJ, Thomas SN, Guldberg RE, McDevitt TC

Biophysical subsets of embryonic stem cells display distinct phenotypic and morphological signatures.

PloS one

Bongiorno T, Gura J, Talwar P, Chambers D, Young KM, Arafat D, Wang G, Jackson-Holmes EL, Qiu P, McDevitt TC, Sulchek T

Lightsheet fluorescence microscopy of branching human fetal kidney.

Kidney international

Isaacson D, Shen J, McCreedy D, Calvert M, McDevitt T, Cunha G, Baskin L

Microparticle-mediated sequestration of cell-secreted proteins to modulate chondrocytic differentiation.

Acta biomaterialia

Rinker TE, Philbrick BD, Hettiaratchi MH, Smalley DM, McDevitt TC, Temenoff JS

Functionalization of microparticles with mineral coatings enhances non-viral transfection of primary human cells.

Scientific reports

Khalil AS, Yu X, Xie AW, Fontana G, Umhoefer JM, Johnson HJ, Hookway TA, McDevitt TC, Murphy WL

Enhanced in vivo retention of low dose BMP-2 via heparin microparticle delivery does not accelerate bone healing in a critically sized femoral defect.

Acta biomaterialia

Hettiaratchi MH, Rouse T, Chou C, Krishnan L, Stevens HY, Li MA, McDevitt TC, Guldberg RE

Differentiation of V2a interneurons from human pluripotent stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Butts JC, McCreedy DA, Martinez-Vargas JA, Mendoza-Camacho FN, Hookway TA, Gifford CA, Taneja P, Noble-Haeusslein L, McDevitt TC

Competitive Protein Binding Influences Heparin-Based Modulation of Spatial Growth Factor Delivery for Bone Regeneration.

Tissue engineering. Part A

Hettiaratchi MH, Chou C, Servies N, Smeekens JM, Cheng A, Esancy C, Wu R, McDevitt TC, Guldberg RE, Krishnan L

Expansion and angiogenic potential of mesenchymal stem cells from patients with critical limb ischemia.

Journal of vascular surgery

Brewster L, Robinson S, Wang R, Griffiths S, Li H, Peister A, Copland I, McDevitt T

Design Principles for Engineering of Tissues from Human Pluripotent Stem Cells.

Current stem cell reports

Matthys OB, Hookway TA, McDevitt TC

A Multi-Modality CMOS Sensor Array for Cell-Based Assay and Drug Screening.

IEEE transactions on biomedical circuits and systems

Chi T, Park JS, Butts JC, Hookway TA, Su A, Zhu C, Styczynski MP, McDevitt TC, Wang H

Aggregate formation and suspension culture of human pluripotent stem cells and differentiated progeny.

Methods (San Diego, Calif.)

Hookway TA, Butts JC, Lee E, Tang H, McDevitt TC

Mineral particles modulate osteo-chondrogenic differentiation of embryonic stem cell aggregates.

Acta biomaterialia

Wang Y, Yu X, Baker C, Murphy WL, McDevitt TC

Quantitative multivariate analysis of dynamic multicellular morphogenic trajectories.

Integrative biology : quantitative biosciences from nano to macro

White DE, Sylvester JB, Levario TJ, Lu H, Streelman JT, McDevitt TC, Kemp ML

Osteogenic embryoid body-derived material induces bone formation in vivo.

Scientific reports

Sutha K, Schwartz Z, Wang Y, Hyzy S, Boyan BD, McDevitt TC

Gelatin methacrylate microspheres for controlled growth factor release.

Acta biomaterialia

Nguyen AH, McKinney J, Miller T, Bongiorno T, McDevitt TC

Microscale generation of cardiospheres promotes robust enrichment of cardiomyocytes derived from human pluripotent stem cells.

Stem cell reports

Nguyen DC, Hookway TA, Wu Q, Jha R, Preininger MK, Chen X, Easley CA, Spearman P, Deshpande SR, Maher K, Wagner MB, McDevitt TC, Xu C

Materials as stem cell regulators.

Nature materials

Murphy WL, McDevitt TC, Engler AJ

Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2.

Biomaterials

Hettiaratchi MH, Miller T, Temenoff JS, Guldberg RE, McDevitt TC

A global assessment of stem cell engineering.

Tissue engineering. Part A

Loring JF, McDevitt TC, Palecek SP, Schaffer DV, Zandstra PW, Nerem RM

Soluble factors secreted by differentiating embryonic stem cells stimulate exogenous cell proliferation and migration.

Stem cell research & therapy

Ngangan AV, Waring JC, Cooke MT, Mandrycky CJ, McDevitt TC

Single-cell analysis of embryoid body heterogeneity using microfluidic trapping array.

Biomedical microdevices

Wilson JL, Suri S, Singh A, Rivet CA, Lu H, McDevitt TC

Fluid shear stress pre-conditioning promotes endothelial morphogenesis of embryonic stem cells within embryoid bodies.

Tissue engineering. Part A

Nsiah BA, Ahsan T, Griffiths S, Cooke M, Nerem RM, McDevitt TC

Scalable culture of human pluripotent stem cells in 3D.

Proceedings of the National Academy of Sciences of the United States of America

McDevitt TC

Microfluidic-based patterning of embryonic stem cells for in vitro development studies.

Lab on a chip

Suri S, Singh A, Nguyen AH, Bratt-Leal AM, McDevitt TC, Lu H

Mechanical stiffness as an improved single-cell indicator of osteoblastic human mesenchymal stem cell differentiation.

Journal of biomechanics

Bongiorno T, Kazlow J, Mezencev R, Griffiths S, Olivares-Navarrete R, McDonald JF, Schwartz Z, Boyan BD, McDevitt TC, Sulchek T

Engineering the emergence of stem cell therapeutics.

Science translational medicine

Healy KE, McDevitt TC, Murphy WL, Nerem RM

Molecular engineering of glycosaminoglycan chemistry for biomolecule delivery.

Acta biomaterialia

Miller T, Goude MC, McDevitt TC, Temenoff JS

A microparticle approach to morphogen delivery within pluripotent stem cell aggregates.

Biomaterials

Bratt-Leal AM, Nguyen AH, Hammersmith KA, Singh A, McDevitt TC

Architectural protein subclasses shape 3D organization of genomes during lineage commitment.

Cell

Phillips-Cremins JE, Sauria ME, Sanyal A, Gerasimova TI, Lajoie BR, Bell JS, Ong CT, Hookway TA, Guo C, Sun Y, Bland MJ, Wagstaff W, Dalton S, McDevitt TC, Sen R, Dekker J, Taylor J, Corces VG

Adhesion strength-based, label-free isolation of human pluripotent stem cells.

Nature methods

Singh A, Suri S, Lee T, Chilton JM, Cooke MT, Chen W, Fu J, Stice SL, Lu H, McDevitt TC, García AJ

Spatial pattern dynamics of 3D stem cell loss of pluripotency via rules-based computational modeling.

PLoS computational biology

White DE, Kinney MA, McDevitt TC, Kemp ML

Hydrodynamic modulation of pluripotent stem cells.

Stem cell research & therapy

Fridley KM, Kinney MA, McDevitt TC

Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size.

Integrative biology : quantitative biosciences from nano to macro

Kinney MA, Saeed R, McDevitt TC

Histone h1 depletion impairs embryonic stem cell differentiation.

PLoS genetics

Zhang Y, Cooke M, Panjwani S, Cao K, Krauth B, Ho PY, Medrzycki M, Berhe DT, Pan C, McDevitt TC, Fan Y

Stiffening of human mesenchymal stem cell spheroid microenvironments induced by incorporation of gelatin microparticles.

Journal of the mechanical behavior of biomedical materials

Baraniak PR, Cooke MT, Saeed R, Kinney MA, Fridley KM, McDevitt TC

Osteogenic differentiation of stem cells alters vitamin D receptor expression.

Stem cells and development

Olivares-Navarrete R, Sutha K, Hyzy SL, Hutton DL, Schwartz Z, McDevitt T, Boyan BD

Systematic engineering of 3D pluripotent stem cell niches to guide blood development.

Biomaterials

Purpura KA, Bratt-Leal AM, Hammersmith KA, McDevitt TC, Zandstra PW

Magnetic manipulation and spatial patterning of multi-cellular stem cell aggregates.

Integrative biology : quantitative biosciences from nano to macro

Bratt-Leal AM, Kepple KL, Carpenedo RL, Cooke MT, McDevitt TC

The multiparametric effects of hydrodynamic environments on stem cell culture.

Tissue engineering. Part B, Reviews

Kinney MA, Sargent CY, McDevitt TC

Development of nano- and microscale chondroitin sulfate particles for controlled growth factor delivery.

Acta biomaterialia

Lim JJ, Hammoudi TM, Bratt-Leal AM, Hamilton SK, Kepple KL, Bloodworth NC, McDevitt TC, Temenoff JS

Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation.

Biomaterials

Bratt-Leal AM, Carpenedo RL, Ungrin MD, Zandstra PW, McDevitt TC

Microsphere size effects on embryoid body incorporation and embryonic stem cell differentiation.

Journal of biomedical materials research. Part A

Carpenedo RL, Seaman SA, McDevitt TC

Hydrodynamic modulation of embryonic stem cell differentiation by rotary orbital suspension culture.

Biotechnology and bioengineering

Sargent CY, Berguig GY, Kinney MA, Hiatt LA, Carpenedo RL, Berson RE, McDevitt TC

Stem cell paracrine actions and tissue regeneration.

Regenerative medicine

Baraniak PR, McDevitt TC

Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Shukla S, Nair R, Rolle MW, Braun KR, Chan CK, Johnson PY, Wight TN, McDevitt TC

Homogeneous and organized differentiation within embryoid bodies induced by microsphere-mediated delivery of small molecules.

Biomaterials

Carpenedo RL, Bratt-Leal AM, Marklein RA, Seaman SA, Bowen NJ, McDonald JF, McDevitt TC

Engineering the embryoid body microenvironment to direct embryonic stem cell differentiation.

Biotechnology progress

Bratt-Leal AM, Carpenedo RL, McDevitt TC

Acellular matrices derived from differentiating embryonic stem cells.

Journal of biomedical materials research. Part A

Nair R, Shukla S, McDevitt TC

Innovation in the culture and derivation of pluripotent human stem cells.

Current opinion in biotechnology

McDevitt TC, Palecek SP

Efficacy of solvent extraction methods for acellularization of embryoid bodies.

Journal of biomaterials science. Polymer edition

Nair R, Ngangan AV, McDevitt TC

Engineering the 3D microenvironment of embryonic stem cells undergoing differentiation.

Bio-medical materials and engineering

McDevitt TC, Carpenedo RL, Sargent CY, Berguig GY, Marklein RA, Seaman S

Spatially organized layers of cardiomyocytes on biodegradable polyurethane films for myocardial repair.

Journal of biomedical materials research. Part A

McDevitt TC, Woodhouse KA, Hauschka SD, Murry CE, Stayton PS

Structural characterization and comparison of RGD cell-adhesion recognition sites engineered into streptavidin.

Acta crystallographica. Section D, Biological crystallography

Le Trong I, McDevitt TC, Nelson KE, Stayton PS, Stenkamp RE

In vitro generation of differentiated cardiac myofibers on micropatterned laminin surfaces.

Journal of biomedical materials research

McDevitt TC, Angello JC, Whitney ML, Reinecke H, Hauschka SD, Murry CE, Stayton PS

Quantitative interrogation of micropatterned biomolecules by surface force microscopy.

Ultramicroscopy

Garrison MD, McDevitt TC, Luginbühl R, Giachelli CM, Stayton P, Ratner BD

Smart and biofunctional streptavidin.

Biomolecular engineering

Stayton PS, Nelson KE, McDevitt TC, Bulmus V, Shimoboji T, Ding Z, Hoffman AS

Constrained cell recognition peptides engineered into streptavidin.

Biotechnology progress

McDevitt TC, Nelson KE, Stayton PS