Barbara Panning, PhD

Professor
Department of Biochemistry and Biophysics
[email protected]
+1 415 514-0448
Research Summary: 
The Panning lab studies mammalian stem cell epigenetics, focusing on X-inactivation and chromatin modifiers.
Mentorship Development: 

4/26/19    Sharpening your Mentoring Skills (SyMS) with Sharon Milgram (Mission Bay)
10/20/20    Gathering in Community: a Training for Faculty and Staff

Publications: 

X chromosome factor Kdm6a enhances cognition independent of its demethylase function in the aging XY male brain.

The journals of gerontology. Series A, Biological sciences and medical sciences

Shaw CK, Abdulai-Saiku S, Marino F, Wang D, Davis EJ, Panning B, Dubal DB

A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease.

Science translational medicine

Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, Yu GQ, White CC, Harris JA, Miller BL, Bennett DA, Arnold AP, De Jager PL, Palop JJ, Panning B, Yokoyama JS, Mucke L, Dubal DB

OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development.

eLife

Hrit J, Goodrich L, Li C, Wang BA, Nie J, Cui X, Martin EA, Simental E, Fernandez J, Liu MY, Nery JR, Castanon R, Kohli RM, Tretyakova N, He C, Ecker JR, Goll M, Panning B

Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program.

Proceedings of the National Academy of Sciences of the United States of America

Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K

Activators and repressors: A balancing act for X-inactivation.

Seminars in cell & developmental biology

Goodrich L, Panning B, Leung KN

SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells.

eLife

Myers SA, Peddada S, Chatterjee N, Friedrich T, Tomoda K, Krings G, Thomas S, Maynard J, Broeker M, Thomson M, Pollard K, Yamanaka S, Burlingame AL, Panning B

Editorial overview: Genome architecture and expression.

Current opinion in genetics & development

Panning B, Segal E

Quantitatively imaging chromosomes by correlated cryo-fluorescence and soft x-ray tomographies.

Biophysical journal

Smith EA, McDermott G, Do M, Leung K, Panning B, Le Gros MA, Larabell CA

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Cell

Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS

The imprinted polycomb group gene Sfmbt2 is required for trophoblast maintenance and placenta development.

Development (Cambridge, England)

Miri K, Latham K, Panning B, Zhong Z, Andersen A, Varmuza S

Quantitative genetic-interaction mapping in mammalian cells.

Nature methods

Roguev A, Talbot D, Negri GL, Shales M, Cagney G, Bandyopadhyay S, Panning B, Krogan NJ

Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells.

Cell stem cell

Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S

Polycomb repressive complex 2 is necessary for the normal site-specific O-GlcNAc distribution in mouse embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Myers SA, Panning B, Burlingame AL

Control of embryonic stem cell identity by nucleosome remodeling enzymes.

Current opinion in genetics & development

Fazzio TG, Panning B

The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation.

Nature structural & molecular biology

Royce-Tolland ME, Andersen AA, Koyfman HR, Talbot DJ, Wutz A, Tonks ID, Kay GF, Panning B

Fine-tuning silencing.

Cell stem cell

Panning B

Chromatin regulation Tip(60)s the balance in embryonic stem cell self-renewal.

Cell cycle (Georgetown, Tex.)

Fazzio TG, Huff JT, Panning B

Epigenomics: a roadmap, but to where?

Science (New York, N.Y.)

Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl K

Transcriptional regulation: it takes a village.

Molecular cell

Panning B, Taatjes DJ

The colocalization transition of homologous chromosomes at meiosis.

Physical review. E, Statistical, nonlinear, and soft matter physics

Nicodemi M, Panning B, Prisco A

A thermodynamic switch for chromosome colocalization.

Genetics

Nicodemi M, Panning B, Prisco A

X-inactivation: it takes two to count.

Current biology : CB

Royce-Tolland M, Panning B

IRE1 signaling affects cell fate during the unfolded protein response.

Science (New York, N.Y.)

Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P

Differences between homologous alleles of olfactory receptor genes require the Polycomb Group protein Eed.

The Journal of cell biology

Alexander MK, Mlynarczyk-Evans S, Royce-Tolland M, Plocik A, Kalantry S, Magnuson T, Panning B

Zinc finger protein Zn72D promotes productive splicing of the maleless transcript.

Molecular and cellular biology

Worringer KA, Panning B

The polycomb group protein SUZ12 regulates histone H3 lysine 9 methylation and HP1 alpha distribution.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology

de la Cruz CC, Kirmizis A, Simon MD, Isono K, Koseki H, Panning B

The XIST noncoding RNA functions independently of BRCA1 in X inactivation.

Cell

Xiao C, Sharp JA, Kawahara M, Davalos AR, Difilippantonio MJ, Hu Y, Li W, Cao L, Buetow K, Ried T, Chadwick BP, Deng CX, Panning B

The site-specific installation of methyl-lysine analogs into recombinant histones.

Cell

Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar GJ, Shokat KM

Poly(ADP-ribose) polymerase 1 is inhibited by a histone H2A variant, MacroH2A, and contributes to silencing of the inactive X chromosome.

The Journal of biological chemistry

Nusinow DA, Hernández-Muñoz I, Fazzio TG, Shah GM, Kraus WL, Panning B

X chromosomes alternate between two states prior to random X-inactivation.

PLoS biology

Mlynarczyk-Evans S, Royce-Tolland M, Alexander MK, Andersen AA, Kalantry S, Gribnau J, Panning B

Mapping post-translational modifications of the histone variant macroH2A1 using tandem mass spectrometry.

The FASEB Journal

Feixia Chu, Dmitri A Nusinow, Robert J Chalkley, Kathrin Plath, Barbara Panning, Alma L Burlingame

The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation.

Nature cell biology

Kalantry S, Mills KC, Yee D, Otte AP, Panning B, Magnuson T

Counting chromosomes: not as easy as 1, 2, 3.

Current biology : CB

Alexander MK, Panning B

Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry.

Molecular & cellular proteomics : MCP

Chu F, Nusinow DA, Chalkley RJ, Plath K, Panning B, Burlingame AL

Developmental regulation of Suz 12 localization.

Chromosoma

de la Cruz CC, Fang J, Plath K, Worringer KA, Nusinow DA, Zhang Y, Panning B

Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.

Proceedings of the National Academy of Sciences of the United States of America

Hernández-Muñoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M

Recognition and modification of seX chromosomes.

Current opinion in genetics & development

Nusinow DA, Panning B

Chromatin modifications on the inactive X chromosome.

Progress in molecular and subcellular biology

Cohen HR, Royce-Tolland ME, Worringer KA, Panning B

Chromatin remodeling in dosage compensation.

Annual review of genetics

Lucchesi JC, Kelly WG, Panning B

Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome.

The Journal of cell biology

Plath K, Talbot D, Hamer KM, Otte AP, Yang TP, Jaenisch R, Panning B

Epigenetic gene regulation by noncoding RNAs.

Current opinion in cell biology

Andersen AA, Panning B

Role of histone H3 lysine 27 methylation in X inactivation.

Science (New York, N.Y.)

Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, Wang H, de la Cruz CC, Otte AP, Panning B, Zhang Y

Identification of an autoimmune serum containing antibodies against the Barr body.

Proceedings of the National Academy of Sciences of the United States of America

Hong B, Reeves P, Panning B, Swanson MS, Yang TP

X inactivation: Tsix and Xist as yin and yang.

Current biology : CB

Mlynarczyk SK, Panning B

Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation.

Nature genetics

Csankovszki G, Panning B, Bates B, Pehrson JR, Jaenisch R

Mammalian X chromosome inactivation.

Novartis Foundation symposium

Jaenisch R, Beard C, Lee J, Marahrens Y, Panning B

Xist-deficient mice are defective in dosage compensation but not spermatogenesis.

Genes & development

Marahrens Y, Panning B, Dausman J, Strauss W, Jaenisch R