Ralph Marcucio, PhD

Professor
Department of Orthopaedic Surgery

First, using cutting-edge genomic technology, Dr. Marcucio is examining how the entire genome responds to orthopaedic trauma. This genome-mining approach is aimed at determining the global genome response during fracture repair and allows the possibility to generate improved, highly innovative therapies for people undergoing fracture repair. Second, Ralph is examining the role that the brain plays during normal development of the facial skeleton. Many facial birth defects have an underlying brain malformation, and the goal of the research is to generate novel therapeutic approaches that will allow correcting facial malformations prior to birth.

Research Summary: 
Craniofacial development, evolutionary biology, trauma, bone repair, angiogenesis
Publications: 

PBX1 and PBX3 transcription factors regulate SHH expression in the Frontonasal Ectodermal Zone through complementary mechanisms.

bioRxiv : the preprint server for biology

Mok CH, Hu D, Losa M, Risolino M, Selleri L, Marcucio RS

Murine Progeria Model Exhibits Delayed Fracture Healing with Dysregulated Local Immune Response.

bioRxiv : the preprint server for biology

Duke VR, Philippon MJ, Lind DRG, Kasler H, Yamaura K, Huard M, Czachor M, Hollenbeck J, Brown J, Garcia A, Fukase N, Marcucio RS, Nelson AL, Hambright WS, Snapper DM, Huard J, Bahney CS

β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model.

Bioactive Materials

Nelson AL, Mancino C, Gao X, Choe JA, Chubb L, Williams K, Czachor M, Marcucio R, Taraballi F, Cooke JP, Huard J, Bahney C, Ehrhart N

Genetic architecture of trait variance in craniofacial morphology.

Genetics

Andrade F, Howell L, Percival CJ, Richtsmeier JT, Marcucio RS, Hallgrímsson B, Cheverud JM

CD47 is Required for Mesenchymal Progenitor Proliferation and Fracture Repair.

Research square

Hankenson K, Zondervan R, Capobianco C, Jenkins D, Reicha J, Frederick L, Lam C, Isenberg J, Ahn J, Marcucio RS

CD47 is Required for Mesenchymal Progenitor Proliferation and Fracture Repair.

bioRxiv : the preprint server for biology

Zondervan RL, Capobianco CA, Jenkins DC, Reicha JD, Fredrick LM, Lam C, Isenberg JS, Ahn J, Marcucio RS, Hankenson KD

Dosage-dependent effects of FGFR2W290R mutation on craniofacial shape and cellular dynamics of the basicranial synchondroses.

Anatomical record (Hoboken, N.J. : 2007)

Richbourg HA, Vidal-García M, Brakora KA, Devine J, Takenaka R, Young NM, Gong SG, Neves A, Hallgrímsson B, Marcucio RS

Chapter 5 Macrophages in tissue engineering and regeneration.

Macrophages Biology and Tissue Inflammation in Health and Disease

Dan Clark, Mary Nakamura, Theodore Miclau, Ralph Marcucio

Author Correction: MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses.

Scientific data

Devine J, Vidal-García M, Liu W, Neves A, Lo Vercio LD, Green RM, Richbourg HA, Marchini M, Unger CM, Nickle AC, Radford B, Young NM, Gonzalez PN, Schuler RE, Bugacov A, Rolian C, Percival CJ, Williams T, Niswander L, Calof AL, Lander AD, Visel A, Jirik FR, Cheverud JM, Klein OD, Birnbaum RY, Merrill AE, Ackermann RR, Graf D, Hemberger M, Dean W, Forkert ND, Murray SA, Westerberg H, Marcucio RS, Hallgrímsson B

The Developmental Basis for Evolvability.

Evolvability

Benedikt Hallgrímsson, J. David Aponte, Marta Vidal-Garcia, Heather Richbourg, Rebecca Green, Nathan M. Young, James M. Cheverud, Anne L. Calof, Arthur D. Lander, Ralph S. Marcucio

Encapsulation of ß-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair.

Frontiers in bioengineering and biotechnology

Rivera KO, Cuylear DL, Duke VR, O'Hara KM, Zhong JX, Elghazali NA, Finbloom JA, Kharbikar BN, Kryger AN, Miclau T, Marcucio RS, Bahney CS, Desai TA

Quantifying the relationship between cell proliferation and morphology during development of the face.

bioRxiv : the preprint server for biology

Green RM, Lo Vercio LD, Dauter A, Barretto EC, Devine J, Vidal-García M, Marchini M, Robertson S, Zhao X, Mahika A, Shakir MB, Guo S, Boughner JC, Dean W, Lander AD, Marcucio RS, Forkert ND, Hallgrímsson B

Altered early immune response after fracture and traumatic brain injury.

Frontiers in immunology

Haffner-Luntzer M, Weber B, Morioka K, Lackner I, Fischer V, Bahney C, Ignatius A, Kalbitz M, Marcucio R, Miclau T

A Shifting Paradigm: Transformation of Cartilage to Bone during Bone Repair.

Journal of dental research

Marcucio RS, Miclau T, Bahney CS

Segmentation of Tissues and Proliferating Cells in Light-Sheet Microscopy Images of Mouse Embryos Using Convolutional Neural Networks.

IEEE access : practical innovations, open solutions

Lo Vercio LD, Green RM, Robertson S, Guo S, Dauter A, Marchini M, Vidal-GARC?A M, Zhao X, Mahika A, Marcucio RS, HALLGR?MSSON B, Forkert ND

Age-related decrease in periostin expression may be associated with attenuated fracture healing in old mice.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Clark D, Doelling J, Hu D, Miclau T, Nakamura M, Marcucio R

Cardiac alterations following experimental hip fracture - inflammaging as independent risk factor.

Frontiers in immunology

Lackner I, Weber B, Pressmar J, Odwarka A, Lam C, Haffner-Luntzer M, Marcucio R, Miclau T, Kalbitz M

Fgf8 dosage regulates jaw shape and symmetry through pharyngeal-cardiac tissue relationships.

Developmental dynamics : an official publication of the American Association of Anatomists

Zbasnik N, Dolan K, Buczkowski SA, Green R, Hallgrimsson B, Marcucio RS, Moon AM, Fish JL

MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses.

Scientific data

Devine J, Vidal-García M, Liu W, Neves A, Lo Vercio LD, Green RM, Richbourg HA, Marchini M, Unger CM, Nickle AC, Radford B, Young NM, Gonzalez PN, Schuler RE, Bugacov A, Rolian C, Percival CJ, Williams T, Niswander L, Calof AL, Lander AD, Visel A, Jirik FR, Cheverud JM, Klein OD, Birnbaum RY, Merrill AE, Ackermann RR, Graf D, Hemberger M, Dean W, Forkert ND, Murray SA, Westerberg H, Marcucio RS, Hallgrímsson B

Developmental Morphospace of Embryonic Brain and Face Growth in the Chicken (Gallus gallus).

The FASEB Journal

Zuzana Vavrušová, Diane Hu, Wei Liu, Ralph S. Marcucio, Benedikt Hallgrímsson, Nathan M. Young

Downstream Branches of the Fibroblast Growth Factor Signaling Pathway Act Interdependently to Shape the Face.

The FASEB Journal

Nicholas J. Hanne, Diane Hu, Charlie Allen, Bilal Shakir, Wei Liu, Benedikt Hallgrímsson, Ralph Marcucio

Relating multivariate shapes to genescapes using phenotype-biological process associations for craniofacial shape.

eLife

Aponte JD, Katz DC, Roth DM, Vidal-García M, Liu W, Andrade F, Roseman CC, Murray SA, Cheverud J, Graf D, Marcucio RS, Hallgrímsson B

Extracellular Matrix Composition Is Altered Alongside Dysmorphology in the Developing Palate.

The FASEB Journal

Nicholas Hanne, Diane Hu, Marta Linde-Medina, Marta Marchini, Benedikt Hallgrímsson, Ralph Marcucio

Integration of Cellular Dynamics and Morphology to Understand Mouse Facial Development.

The FASEB Journal

Rebecca Green, Lucas Lo Vercio, Andreas Dauter, Si Han Guo, Samuel Robertson, Marta Marchini, Marta Vidal Garcia, Xiang Zhao, Ralph Marcucio, Nils Forkert, Benedikt Hallgrimsson

Mapping the Multi-Modal Distribution of Craniofacial Phenotypes in NOSIP Mutants.

The FASEB Journal

Heather Richbourg, Rebecca Green, Jay Devine, Marta Vidal Garcia, Benedikt Hallgrimsson, Ralph Marcucio

Systemic and local cardiac inflammation after experimental long bone fracture, traumatic brain injury and combined trauma in mice.

Journal of Orthopaedic Translation

Lackner I, Weber B, Haffner-Luntzer M, Hristova S, Gebhard F, Lam C, Morioka K, Marcucio RS, Miclau T, Kalbitz M

Creating Avian Forebrain Chimeras to assess Facial Development.

Journal of visualized experiments : JoVE

Local injections of ß-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion.

Scientific reports

Rivera KO, Russo F, Boileau RM, Tomlinson RE, Miclau T, Marcucio RS, Desai TA, Bahney CS

Chondrocyte-to-osteoblast transformation in mandibular fracture repair.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Wong SA, Hu DP, Slocum J, Lam C, Nguyen M, Miclau T, Marcucio RS, Bahney CS

A novel mouse model to study fracture healing at the proximal femur.

Bone reports

Melanie Haffner-Luntzer, Birte Weber, Charles Lam, Verena Fischer, Miriam Kalbitz, Anita Ignatius, Ralph S. Marcucio, Theodore Miclau

Pak1ip1 Loss-of-Function Leads to Cell Cycle Arrest, Loss of Neural Crest Cells, and Craniofacial Abnormalities.

Frontiers in cell and developmental biology

Panoutsopoulos AA, De Crescenzo AH, Lee A, Lu AM, Ross AP, Borodinsky LN, Marcucio R, Trainor PA, Zarbalis KS

miR-199 Family Contributes to Regulation of Sonic Hedgehog Expression During Craniofacial Development.

Developmental dynamics : an official publication of the American Association of Anatomists

Richbourg HA, Hu DP, Xu Y, Barczak AJ, Marcucio RS

Blocking Kv1.3 potassium channels psrevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice.

British journal of anaesthesia

Lai LK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M

Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes.

PloS one

Katz DC, Aponte JD, Liu W, Green RM, Mayeux JM, Pollard KM, Pomp D, Munger SC, Murray SA, Roseman CC, Percival CJ, Cheverud J, Marcucio RS, Hallgrímsson B

A novel mouse model to study fracture healing of the proximal femur.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Haffner-Luntzer M, Weber B, Lam C, Fischer V, Lackner I, Ignatius A, Kalbitz M, Marcucio RS, Miclau T

Determining the Role of Extracellular Matrix Compliance on Facial Morphogenesis.

The FASEB Journal

Nicholas Jean Hanne, Diane Hu, Marta Linde-Medina, Benedikt Hallgrimsson, Ralph S. Marcucio

Late embryonic skull anomalies in mice carrying the Fgfr2 W290R Crouzon mutation.

The FASEB Journal

M. Kathleen Pitirri, Susan M. Motch Perrine, Risa Takenaka, Ralph Marcucio, Joan Richtsmeier

Mapping the Multi-Modal Distribution of Craniofacial Phenotypes in NOSIP Mutants.

The FASEB Journal

Heather A. Richbourg, Alexa Saliou, Jay Devine, Rebecca Green, Meike Hoffmeister, Stefanie Oess, Benedikt Hallgrimsson, Ralph Marcucio

Mapping the relationship between proliferation and morphology in the developing mouse face.

The FASEB Journal

Rebecca M. Green, Lucas Lo Vercio, Sihan Guo, Andreas Dauter, Marta Marchini, Xiang Xhao, Ralph S. Marcucio, Benedikt Hallgrimsson

Regulatory Dynamics of Midfacial Growth in Evolution and Disease.

The FASEB Journal

Licia Selleri, Ian Welsh, Karissa Hansen, Marco Osterwalder, Marta Losa-Llabata, Julie Wells, Carol Bult, Timothy Mohun, Diane Hu, Ralph Marcucio, Axel Visel, Tomek Swigut

Age-related changes to macrophages are detrimental to fracture healing in mice.

Aging cell

Clark D, Brazina S, Yang F, Hu D, Hsieh CL, Niemi EC, Miclau T, Nakamura MC, Marcucio R

SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation.

BMC biology

Zhang Y, Zheng L, Le M, Nakano Y, Chan B, Huang Y, Torbaty PM, Kohwi Y, Marcucio R, Habelitz S, Den Besten PK, Kohwi-Shigematsu T

AGE-RELATED CHANGES TO MACROPHAGES AFFECT FRACTURE HEALING.

Innovation in Aging

Daniel Clark, Theodore Miclau, Mary Nakamura, Ralph Marcucio

Integration and the Developmental Genetics of Allometry.

Integrative and comparative biology

Hallgrímsson B, Katz D, Aponte JD, Larson JE, Devine J, Gonzalez P, Young NM, Roseman CC, Marcucio RS

Non-linear gene expression-phenotype relationships contribute to variation and clefting in the A/WySn mouse.

Developmental dynamics : an official publication of the American Association of Anatomists

Green RM, Leach CL, Diewert VM, Aponte JD, Schmidt EJ, Cheverud JM, Roseman CC, Young NM, Marcucio RS, Hallgrimsson B

Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma.

Scientific reports

Morioka K, Marmor Y, Sacramento JA, Lin A, Shao T, Miclau KR, Clark DR, Beattie MS, Marcucio RS, Miclau T, Ferguson AR, Bresnahan JC, Bahney CS

Fracture repair in the elderly: Clinical and experimental considerations.

Injury

Meinberg EG, Clark D, Miclau KR, Marcucio R, Miclau T

Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via ß-AR signaling.

Proceedings of the National Academy of Sciences of the United States of America

Haffner-Luntzer M, Foertsch S, Fischer V, Prystaz K, Tschaffon M, Mödinger Y, Bahney CS, Marcucio RS, Miclau T, Ignatius A, Reber SO

Emergent Properties of Facial Morphogenesis Regulated by Fgf Signaling.

The FASEB Journal

Ralph Marcucio, Diane Hu, Benedikt Hallgrimsson, Nathan Young

Integration and the genetics of variation in facial shape.

The FASEB Journal

Benedikt Hallgrimsson, Jose David Aponte, David C Katz, Jordan J Bannister, Rebecca M Green, Nathan M Young, James M Cheverud, Nils Daniel Forkert, Ralph S Marcucio

Modeling the Development of Cleft Lip and Palate in Variable Clefting Mouse Strains.

The FASEB Journal

Rebecca M. Green, Courtney L. Leach, Sihan Guo, Virginia Diewert, Ralph S. Marcucio, Benedikt Hallgrimsson

The Silent Treatment: miR199 Family Silences Shh during Craniofacial Development.

The FASEB Journal

Heather Ashley Richbourg, Diane Hu, Ralph Marcucio

The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting.

American journal of medical genetics. Part A

Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA

The Cellular Biology of Fracture Healing.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Bahney CS, Zondervan RL, Allison P, Theologis A, Ashley J, Ahn J, Miclau T, Marcucio R, Hankenson KD

The Developmental-Genetics of Canalization.

Seminars in cell & developmental biology

Hallgrimsson B, Green RM, Katz D, Fish JL, Bernier FPJ, Roseman CC, Young NM, Cheverud JM, Marcucio RS

Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair-A New Frontier for Developmental Engineering.

Frontiers in bioengineering and biotechnology

Wong SA, Rivera KO, Miclau T, Alsberg E, Marcucio RS, Bahney CS

The Society for Craniofacial Genetics and Developmental Biology 40th annual meeting.

American journal of medical genetics. Part A

Gammill L, Cox T, Moody S, Taneyhill L, Trainor P, Marcucio R

Quantifying the Genotype to Phenotype Map in Developing Mice.

The FASEB Journal

Heather A Richbourg, Nathan Young, Risa Takenaka, Ralph Marcucio

Understanding the development of variable craniofacial phenotypes caused by altered methylation affecting Wnt9b in A-strain mice.

The FASEB Journal

Rebecca M. Green, Courtney L. Leach, Eric Schmidt, Virginia Diewert, Ralph S. Marcucio, Benedikt Hallgrimsson

Untangling Sources of Phenotypic Variation Characterizing the Craniofacial Disease Holoprosencephaly.

The FASEB Journal

Alexis Lainoff, Nathan Young, Benedikt Hallgrimsson, Ralph Marcucio

Simulation enabled search for explanatory mechanisms of the fracture healing process.

PLoS computational biology

Kennedy RC, Marmor M, Marcucio R, Hunt CA

Living tissues are more than cell clusters: The extracellular matrix as a driving force in morphogenesis.

Progress in biophysics and molecular biology

Linde-Medina M, Marcucio R

Developmental constraint through negative pleiotropy in the zygomatic arch.

EvoDevo

Percival CJ, Green R, Roseman CC, Gatti DM, Morgan JL, Murray SA, Donahue LR, Mayeux JM, Pollard KM, Hua K, Pomp D, Marcucio R, Hallgrímsson B

Developmental nonlinearity drives phenotypic robustness.

Nature communications

Green RM, Fish JL, Young NM, Smith FJ, Roberts B, Dolan K, Choi I, Leach CL, Gordon P, Cheverud JM, Roseman CC, Williams TJ, Marcucio RS, Hallgrímsson B

Effects of Aging on Fracture Healing.

Current osteoporosis reports

Clark D, Nakamura M, Miclau T, Marcucio R

Reverse engineering development: Crosstalk opportunities between developmental biology and tissue engineering.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Marcucio RS, Qin L, Alsberg E, Boerckel JD

Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing?

Frontiers in cell and developmental biology

Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T

Fgf8 dosage and tissue interactions contribute to jaw asymmetry in disease.

The FASEB Journal

Jennifer L. Fish, Katie Dolan, Rebecca Green, Ralph S Marcucio, Benedikt Hallgrimsson

QTL Analysis of a Trade-off in Bone Length within the Mouse Zygomatic Arch.

The FASEB Journal

Christopher J. Percival, Rebecca Green, Daniel M. Gatti, Daniel Pomp, Charles C. Roseman, Ralph Marcucio, Benedikt Hallgrímsson

Shaping the sound of voice.

eLife

Marcucio R

Craniofacial diversification in the domestic pigeon and the evolution of the avian skull.

Nature ecology & evolution

Young NM, Linde-Medina M, Fondon JW, Hallgrímsson B, Marcucio RS

Quantifying three-dimensional morphology and RNA from individual embryos.

Developmental dynamics : an official publication of the American Association of Anatomists

Green RM, Leach CL, Hoehn N, Marcucio RS, Hallgrímsson B

The society for craniofacial genetics and developmental biology 39th annual meeting.

American journal of medical genetics. Part A

Fish JL, Albertson C, Harris MP, Lozanoff S, Marcucio RS, Richtsmeier JT, Trainor PA

Development Shapes a Consistent Inbreeding Effect in Mouse Crania of Different Line Crosses.

Journal of experimental zoology. Part B, Molecular and developmental evolution

Pavlicev M, Mitteroecker P, Gonzalez PM, Rolian C, Jamniczky H, Villena FP, Marcucio R, Spritz R, Hallgrimsson B

Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes.

Development (Cambridge, England)

Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS

Future Treatment Strategies for Delayed Bone Healing: An Osteoimmunologic Approach.

The Journal of the American Academy of Orthopaedic Surgeons

Schmidt-Bleek K, Marcucio R, Duda G

FGFR-associated craniosynostosis syndromes and gastrointestinal defects.

American journal of medical genetics. Part A

Hibberd CE, Bowdin S, Arudchelvan Y, Forrest CR, Brakora KA, Marcucio RS, Gong SG

Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel.

Journal of evolutionary biology

Gonzalez PN, Pavlicev M, Mitteroecker P, Pardo-Manuel de Villena F, Spritz RA, Marcucio RS, Hallgrímsson B

The society for craniofacial genetics and developmental biology 38th annual meeting.

American journal of medical genetics. Part A

Taneyhill LA, Hoover-Fong J, Lozanoff S, Marcucio R, Richtsmeier JT, Trainor PA

60 Minutes of Tension: The Hour Long Research Talk.

The FASEB Journal

Ralph Marcucio

Evolvability and the Diversification of the Craniofacial Skeleton in the Domesticated Pigeon ( Columba livia ).

The FASEB Journal

Marta Linde-Medina, John Fondon, Ralph Marcucio, Benedikt Hallgrímsson, Nathan M. Young

Facial surface morphology predicts variation in internal skeletal shape.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

Young NM, Sherathiya K, Gutierrez L, Nguyen E, Bekmezian S, Huang JC, Hallgrímsson B, Lee JS, Marcucio RS

Factors affecting craniofacial development in a mouse model of Crouzon Syndrome.

The FASEB Journal

Katherine Brakora, Christopher J Percival, Rebecca Green, Siew-Ging Gong, Benedikt Hallgrimsson, Ralph Marcucio

Matrix Reloaded: Devitalized Cartilage as a Functional Extracellular Niche to Promote Osteogenesis and Angiogenesis.

The FASEB Journal

Jaselle M Perry, Donna M Poscablo, Brandon T Gaston, Diane P Hu, Theodore Miclau, Karen L Christman, Ralph S Marcucio, Chelsea S Bahney

Trans differentiation of Chondrocytes to Osteoblasts during Endochondral Ossification in the Healing Mandible.

The FASEB Journal

Sarah Anne Wong, Diane Hu, Theodore Miclau, Chelsea Bahney, Ralph Marcucio

Transdifferentiation of Chondrocytes to Osteoblasts during Bone Fracture Healing.

The FASEB Journal

Ralph Marcucio, Diane Hu, Frank Yang, Chelsea Bahney, Theodore Miclau

Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes.

Tissue engineering. Part A

Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC

Beyond cell proliferation in avian facial morphogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists

Linde-Medina M, Hallgrímsson B, Marcucio R

Stem Cell Therapies in Orthopaedic Trauma.

Journal of orthopaedic trauma

Marcucio RS, Nauth A, Giannoudis PV, Bahney C, Piuzzi NS, Muschler G, Miclau T

Tissue engineering strategies for promoting vascularized bone regeneration.

Bone

Almubarak S, Nethercott H, Freeberg M, Beaudon C, Jha A, Jackson W, Marcucio R, Miclau T, Healy K, Bahney C

Morphometrics, 3D Imaging, and Craniofacial Development.

Current topics in developmental biology

Hallgrimsson B, Percival CJ, Green R, Young NM, Mio W, Marcucio R

Facial Morphogenesis: Physical and Molecular Interactions Between the Brain and the Face.

Current topics in developmental biology

Marcucio R, Hallgrimsson B, Young NM

Genetics of murine craniofacial morphology: diallel analysis of the eight founders of the Collaborative Cross.

Journal of anatomy

Percival CJ, Liberton DK, Pardo-Manuel de Villena F, Spritz R, Marcucio R, Hallgrímsson B

Correlations Between the Morphology of Sonic Hedgehog Expression Domains and Embryonic Craniofacial Shape.

Evolutionary biology

Xu Q, Jamniczky H, Hu D, Green RM, Marcucio RS, Hallgrimsson B, Mio W

Signals from the brain induce variation in avian facial shape.

Developmental dynamics : an official publication of the American Association of Anatomists

Hu D, Young NM, Xu Q, Jamniczky H, Green RM, Mio W, Marcucio RS, Hallgrimsson B

Divergence of craniofacial developmental trajectories among avian embryos.

Developmental dynamics : an official publication of the American Association of Anatomists

Smith FJ, Percival CJ, Young NM, Hu D, Schneider RA, Marcucio RS, Hallgrimsson B

Role of muscle stem cells during skeletal regeneration.

Stem cells (Dayton, Ohio)

Abou-Khalil R, Yang F, Lieu S, Julien A, Perry J, Pereira C, Relaix F, Miclau T, Marcucio R, Colnot C

Facial development and alterations in FGF signaling in a mouse model of Crouzon Syndrome.

The FASEB Journal

Katherine Brakora, Yolanda Ho, Alexis Lainoff, Jennifer Wong, Siew-Ging Gong, Benedikt Hallgrimsson, Ralph Marcucio

Mechanisms of FGF-Mediated Morphogenesis.

The FASEB Journal

Ralph Marcucio

A comparative examination of odontogenic gene expression in both toothed and toothless amniotes.

Journal of experimental zoology. Part B, Molecular and developmental evolution

Lainoff AJ, Moustakas-Verho JE, Hu D, Kallonen A, Marcucio RS, Hlusko LJ

The multifaceted role of the vasculature in endochondral fracture repair.

Frontiers in endocrinology

Bahney CS, Hu DP, Miclau T, Marcucio RS

A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face.

Development (Cambridge, England)

Hu D, Young NM, Li X, Xu Y, Hallgrímsson B, Marcucio RS

Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice.

Disease models & mechanisms

Billington CJ, Schmidt B, Marcucio RS, Hallgrimsson B, Gopalakrishnan R, Petryk A

Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage.

Disease models & mechanisms

Green RM, Feng W, Phang T, Fish JL, Li H, Spritz RA, Marcucio RS, Hooper J, Jamniczky H, Hallgrímsson B, Williams T

Let's face it--complex traits are just not that simple.

PLoS genetics

Hallgrimsson B, Mio W, Marcucio RS, Spritz R

Surface landmark quantification of embryonic mouse craniofacial morphogenesis.

BMC developmental biology

Percival CJ, Green R, Marcucio R, Hallgrímsson B

Biological perspectives of delayed fracture healing.

Injury

Hankenson KD, Zimmerman G, Marcucio R

A comparative examination of odontogenic markers in both toothed and toothless amniotes (344.3).

The FASEB Journal

Alexis Lainoff, Jacqueline Moustakas, Aki Kallonen, Keijo Hämälainen, Kathleen Smith, Diane Hu, Ralph Marcucio, Leslea Hlusko

Endochondral bone tissue engineering: using cartilage to drive vascularized bone regeneration (87.6).

The FASEB Journal

Chelsea Bahney, Amit Jha, Diane Hu, Aaron Taylor, Hayley Britz, Benedikt Hallgrimsson, Ted Miclau, Ralph Marcucio

Therapeutic delivery of placental stem cells to modulate vasculature and promote fracture repair (342.6).

The FASEB Journal

Chelsea Bahney, Aaron Taylor, Ali Sadat, Kathryn Tormos, Ted Miclau, Emin Maltepe, Ralph Marcucio

Transdifferentiation of hypertrophic chondrocytes during endochondral bone repair by activation of pluripotent stem cell programs (216.1).

The FASEB Journal

Chelsea Bahney, Diane Hu, Federico Ferro, Aaron Taylor, Ted Miclau, Ralph Marcucio

Embryonic bauplans and the developmental origins of facial diversity and constraint.

Development (Cambridge, England)

Young NM, Hu D, Lainoff AJ, Smith FJ, Diaz R, Tucker AS, Trainor PA, Schneider RA, Hallgrímsson B, Marcucio RS

Delayed bone regeneration is linked to chronic inflammation in murine muscular dystrophy.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Abou-Khalil R, Yang F, Mortreux M, Lieu S, Yu YY, Wurmser M, Pereira C, Relaix F, Miclau T, Marcucio RS, Colnot C

Modulation of macrophage activity during fracture repair has differential effects in young adult and elderly mice.

Journal of orthopaedic trauma

Slade Shantz JA, Yu YY, Andres W, Miclau T, Marcucio R

Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Bahney CS, Hu DP, Taylor AJ, Ferro F, Britz HM, Hallgrimsson B, Johnstone B, Miclau T, Marcucio RS

Selective estrogen receptor modulation prevents scoliotic curve progression: radiologic and histomorphometric study on a bipedal C57Bl6 mice model.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Demirkiran G, Dede O, Yalcin N, Akel I, Marcucio R, Acaroglu E

The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos.

Disease models & mechanisms

Smith F, Hu D, Young NM, Lainoff AJ, Jamniczky HA, Maltepe E, Hallgrimsson B, Marcucio RS

Embryonic origins of novelty and constraint in the amniote upper jaw.

The FASEB Journal

Nathan Young, Diane Hu, Alexis Lainoff, Benedikt Hallgrímsson, Ralph Marcucio

Disruption of thrombospondin-2 accelerates ischemic fracture healing.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Miedel E, Dishowitz MI, Myers MH, Dopkin D, Yu YY, Miclau TS, Marcucio R, Ahn J, Hankenson KD

Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules.

Developmental biology

Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ

The role of oxygen during fracture healing.

Bone

Lu C, Saless N, Wang X, Sinha A, Decker S, Kazakia G, Hou H, Williams B, Swartz HM, Hunt TK, Miclau T, Marcucio RS

MMP9 regulates the cellular response to inflammation after skeletal injury.

Bone

Wang X, Yu YY, Lieu S, Yang F, Lang J, Lu C, Werb Z, Hu D, Miclau T, Marcucio R, Colnot C

The generation of variation and the developmental basis for evolutionary novelty.

Journal of experimental zoology. Part B, Molecular and developmental evolution

Hallgrímsson B, Jamniczky HA, Young NM, Rolian C, Schmidt-Ott U, Marcucio RS

Anti-inflammatory treatment increases angiogenesis during early fracture healing.

Archives of orthopaedic and trauma surgery

Lu C, Xing Z, Wang X, Mao J, Marcucio RS, Miclau T

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects.

Journal of Visualized Experiments

Yan-yiu Yu, Chelsea Bahney, Diane Hu, Ralph S. Marcucio, Theodore Miclau, III

A Novel Gene Crispld2 may Contribute to Facial Dysmophology in a Chicken Model of Crouzon's Syndrome.

The FASEB Journal

Xin Li, Stephen Tropp, Nathan Young, Benedikt Hallgrimsson, Ralph Marcucio

Modulation of Shh signaling by microRNAs.

The FASEB Journal

Yanhua Xu, Diane Hu, Rebecca Barbeau, Andrea Barczak, Ralph Marcucio

Neural crest cells pattern the surface cephalic ectoderm during FEZ formation.

Developmental dynamics : an official publication of the American Association of Anatomists

Hu D, Marcucio RS

The Phenogenomics of Craniofacial Shape.

The FASEB Journal

Benedikt Hallgrimsson, Heather A. Jamniczky, Neus Martínez-Abadías, Nathan M. Young, Ralph S. Marcucio

Tissue Interactions that Regulate Facial Morphogenesis.

The FASEB Journal

Ralph Marcucio, Nathan Young, Diane Hu, Benedikt Hallgrimsson

Tissue engineering bone by recapitulating developmental and repair programs offers improved biological outcomes.

The FASEB Journal

Chelsea Shields Bahney, Diane Hu, Theodore Miclau, Ralph Marcucio

The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the "metabolic" workgroup of the Fondation Yves Cotrel.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Acaroglu E, Bobe R, Enouf J, Marcucio R, Moldovan F, Moreau A

Signaling by SHH rescues facial defects following blockade in the brain.

Developmental dynamics : an official publication of the American Association of Anatomists

Chong HJ, Young NM, Hu D, Jeong J, McMahon AP, Hallgrimsson B, Marcucio RS

Vascular endothelial growth factor improves bone repair in a murine nonunion model.

The Iowa orthopaedic journal

Ogilvie CM, Lu C, Marcucio R, Lee M, Thompson Z, Hu D, Helms JA, Miclau T

Is decreased bone mineral density associated with development of scoliosis? A bipedal osteopenic rat model.

Scoliosis

Dede O, Akel I, Demirkiran G, Yalcin N, Marcucio R, Acaroglu E

Epigenetic integration of the developing brain and face.

Developmental dynamics : an official publication of the American Association of Anatomists

Parsons TE, Schmidt EJ, Boughner JC, Jamniczky HA, Marcucio RS, Hallgrímsson B

Mechanical stability affects angiogenesis during early fracture healing.

Journal of orthopaedic trauma

Lu C, Saless N, Hu D, Wang X, Xing Z, Hou H, Williams B, Swartz HM, Colnot C, Miclau T, Marcucio RS

Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy.

Osteoarthritis and cartilage

Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T

Effects of Bone Morphogenetic Proteins on TGF-beta, Wnt and BMP Pathways During Tibial Fracture Repair.

The FASEB Journal

Yan Yiu Yu, Shirley Lieu, Theodore Miclau, Celine Colnot, Ralph Marcucio

The cellular basis of hypoxia induced craniofacial malformations.

The FASEB Journal

Francis Joel Smith, Ralph S Marcucio, Diane Hu, Benedikt Hallgrimsson

Assessing Signaling Properties of Ectodermal Epithelia During Craniofacial Development.

Journal of Visualized Experiments

Diane Hu, Ralph S. Marcucio

Assessing signaling properties of ectodermal epithelia during craniofacial development.

Journal of visualized experiments : JoVE

Hu D, Marcucio RS

Mechanisms that underlie co-variation of the brain and face.

Genesis (New York, N.Y. : 2000)

Marcucio RS, Young NM, Hu D, Hallgrimsson B

Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2.

Disease models & mechanisms

Lieu S, Hansen E, Dedini R, Behonick D, Werb Z, Miclau T, Marcucio R, Colnot C

Quantitative analyses link modulation of sonic hedgehog signaling to continuous variation in facial growth and shape.

Development (Cambridge, England)

Young NM, Chong HJ, Hu D, Hallgrímsson B, Marcucio RS

Trauma-induced inflammation and fracture healing.

Journal of orthopaedic trauma

Pape HC, Marcucio R, Humphrey C, Colnot C, Knobe M, Harvey EJ

Rejuvenation of the inflammatory system stimulates fracture repair in aged mice.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Xing Z, Lu C, Hu D, Miclau T, Marcucio RS

Action of IL-1beta during fracture healing.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lange J, Sapozhnikova A, Lu C, Hu D, Li X, Miclau T, Marcucio RS

Recombinant human bone morphogenetic protein-7 enhances fracture healing in an ischemic environment.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lu C, Xing Z, Yu YY, Colnot C, Miclau T, Marcucio RS

Multiple roles for CCR2 during fracture healing.

Disease models & mechanisms

Xing Z, Lu C, Hu D, Yu YY, Wang X, Colnot C, Nakamura M, Wu Y, Miclau T, Marcucio RS

Absence of beta3 integrin accelerates early skeletal repair.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Hu D, Lu C, Sapozhnikova A, Barnett M, Sparrey C, Miclau T, Marcucio RS

Deciphering the Palimpsest: Studying the Relationship Between Morphological Integration and Phenotypic Covariation.

Evolutionary biology

Hallgrímsson B, Jamniczky H, Young NM, Rolian C, Parsons TE, Boughner JC, Marcucio RS

Basic research in orthopedic surgery: Current trends and future directions.

Indian journal of orthopaedics

Lu C, Buckley JM, Colnot C, Marcucio R, Miclau T

Hypoxia as an Environmental Cause of Holoprosencephaly.

The FASEB Journal

Francis Joel Smith, Ralph S Marcucio

Rescuing craniofacial development in an avian model of holoprosencephaly.

The FASEB Journal

H. Jonathan Chong, Ralph Marcucio

The relationship between variable SHH signaling and the severity of structural defects in the face and brain.

The FASEB Journal

Nathan M. Young, Diane Hu, H. Jonathan Chong, Benedikt Hallgrímsson, Wei Liu, Ralph Marcucio

The effect of calmodulin antagonists on experimental scoliosis: a pinealectomized chicken model.

Spine

Akel I, Kocak O, Bozkurt G, Alanay A, Marcucio R, Acaroglu E

The effect of calmodulin antagonists on scoliosis: bipedal C57BL/6 mice model.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Akel I, Demirkiran G, Alanay A, Karahan S, Marcucio R, Acaroglu E

Effect of bone morphogenetic protein signaling on development of the jaw skeleton.

Developmental dynamics : an official publication of the American Association of Anatomists

Hu D, Colnot C, Marcucio RS

Effect of age on vascularization during fracture repair.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lu C, Hansen E, Sapozhnikova A, Hu D, Miclau T, Marcucio RS

Tibial fracture decreases oxygen levels at the site of injury.

The Iowa orthopaedic journal

Lu C, Rollins M, Hou H, Swartz HM, Hopf H, Miclau T, Marcucio RS

Effects of delayed stabilization on fracture healing.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Miclau T, Lu C, Thompson Z, Choi P, Puttlitz C, Marcucio R, Helms JA

Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration.

PloS one

Behonick DJ, Xing Z, Lieu S, Buckley JM, Lotz JC, Marcucio RS, Werb Z, Miclau T, Colnot C

Ischemia leads to delayed union during fracture healing: a mouse model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lu C, Miclau T, Hu D, Marcucio RS

Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development.

Pediatrics

Haggstrom AN, Lammer EJ, Schneider RA, Marcucio R, Frieden IJ

Assessing angiogenesis during fracture healing.

The Iowa orthopaedic journal

Lu C, Marcucio R, Miclau T

Molecular interactions coordinating the development of the forebrain and face.

Developmental biology

Marcucio RS, Cordero DR, Hu D, Helms JA

Cellular basis for age-related changes in fracture repair.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lu C, Miclau T, Hu D, Hansen E, Tsui K, Puttlitz C, Marcucio RS

The Collaborative Cross, a community resource for the genetic analysis of complex traits.

Nature genetics

Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F

Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes.

The Journal of clinical investigation

Cordero D, Marcucio R, Hu D, Gaffield W, Tapadia M, Helms JA

Morphogenesis of blood vessels in the head muscles of avian embryo: spatial, temporal, and VEGF expression analyses.

Developmental dynamics : an official publication of the American Association of Anatomists

Ruberte J, Carretero A, Navarro M, Marcucio RS, Noden D

A zone of frontonasal ectoderm regulates patterning and growth in the face.

Development (Cambridge, England)

Hu D, Marcucio RS, Helms JA

Prenatal morphogenesis of the human mental foramen.

European journal of oral sciences

Radlanski RJ, Renz H, Müller U, Schneider RS, Marcucio RS, Helms JA

Differentiation of avian craniofacial muscles: I. Patterns of early regulatory gene expression and myosin heavy chain synthesis.

Developmental dynamics : an official publication of the American Association of Anatomists

Noden DM, Marcucio R, Borycki AG, Emerson CP

Myotube heterogeneity in developing chick craniofacial skeletal muscles.

Developmental dynamics : an official publication of the American Association of Anatomists

Marcucio RS, Noden DM

In vitro interaction between oviduct epithelial and equine sperm.

Archives of andrology

Ellington JE, Ignotz GG, Varner DD, Marcucio RS, Mathison P, Ball BA