Eric Huang, MD, PhD

Professor
Department of Pathology
+1 415 476-8525

I am a physician-scientist with the unique combination of skills in cellular and molecular neurobiology and diagnostic neuropathology. There are two general areas of research in my laboratory, both supported by extramural funding. The first area focuses on the cellular and molecular mechanisms that govern neural circuit development and function. Another major area of research in my lab focuses on the molecular mechanisms of neurodegenerative diseases, including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). In addition to our seminal work to investigate disease mechanisms in model organisms, we have made every effort to directly connect our research with human diseases. To this end, I have spearheaded the efforts to establish the UC Pediatric Neuropathology Consortium. The success of this endeavor is underscored by our extensive collaborations with colleagues within and outside UCSF, which lead to many important discoveries. Most importantly, these studies revealed previously unrecognized role of neural circuit dysfunctions in neurodevelopmental and neurodegenerative diseases, and re-define our approaches toward investigating the molecular and cellular pathways in these devastating diseases.

Research Summary
Molecular Mechanisms Controlling Neuronal and Neurovascular Development

Publications

Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers.

Annals of clinical and translational neurology

Flagan TM, Chu SA, Häkkinen S, Zhang L, McFall D, Rohrer JD, Brown JA, Lee AJ, Fernhoff K, Pasquini L, Rankin KP, Mandelli ML, Gorno-Tempini ML, Yokoyama JS, Sturm VE, Appleby B, Dickerson BC, Domoto-Reilly K, Foroud T, Geschwind DH, Ghoshal N, Graff-Radford NR, Hsiung GR, Huang EJ, Huey E, Kantarci K, Litvan I, Mackenzie IR, Mendez MF, Onyike CU, Petrucelli L, Ramos EM, Roberson ED, Rojas JC, Tartaglia MC, Toga AW, Weintraub S, Forsberg LK, Heuer HW, Boeve BF, Boxer AL, Rosen HJ, Miller BL, Moreno F, Seeley WW, Lee SE, ALLFTD Consortium

Clinical and Neurophysiological Phenotypes in Neonates With BRAT1 Encephalopathy.

Neurology

Carapancea E, Cornet MC, Milh M, De Cosmo L, Huang EJ, Granata T, Striano P, Ceulemans B, Stein A, Morris-Rosendahl D, Conti G, Mitra N, Raymond FL, Rowitch DH, Solazzi R, Vercellino F, De Liso P, D'Onofrio G, Boniver C, Danhaive O, Carkeek K, Salpietro V, Weckhuysen S, Fedrigo M, Angelini A, Castellotti B, Lederer D, Benoit V, Raviglione F, Guerrini R, Dilena R, Cilio MR

Developmental dynamics of RNA translation in the human brain.

Nature neuroscience

Duffy EE, Finander B, Choi G, Carter AC, Pritisanac I, Alam A, Luria V, Karger A, Phu W, Sherman MA, Assad EG, Pajarillo N, Khitun A, Crouch EE, Ganesh S, Chen J, Berger B, Sestan N, O'Donnell-Luria A, Huang EJ, Griffith EC, Forman-Kay JD, Moses AM, Kalish BT, Greenberg ME

Label-retention expansion microscopy.

The Journal of cell biology

Shi X, Li Q, Dai Z, Tran AA, Feng S, Ramirez AD, Lin Z, Wang X, Chow TT, Chen J, Kumar D, McColloch AR, Reiter JF, Huang EJ, Seiple IB, Huang B

Does Adult Neurogenesis Persist in the Human Hippocampus?

Cell stem cell

Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A

Clinicopathological correlations in behavioural variant frontotemporal dementia.

Brain : a journal of neurology

Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW

Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.

Neuroscience research

Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H