Aras Mattis, MD, PhD

Associate Professor
Pathology
[email protected]
+1 415 514-3062

Research Overview: The Mattis Lab is focused on identifying molecular mechanisms in normal human liver function as well as understanding complex diseases such as non-alcoholic fatty liver disease (NAFLD). In order to develop better models of this disease process we are using human induced pluripotent stem cells that are then differentiated to human hepatocyte like cells (iPSC-derived hepatocytes). Using a combination of these human derived in vitro hepatocyte models and mouse model systems we strive to develop an improved understanding of this disease.

In addition we have small projects to characterize cystic fibrosis liver disease, hepatocellular carcinoma, and cholangiocarcinoma. Located in the UCSF Department of Pathology, we make use of both collaborative efforts and IRB approved access to archived and fresh human tissue.

Primary Thematic Area: Developmental & Stem Cell Biology

Secondary Thematic Area: Tissue / Organ Biology & Endocrinology

Research Summary: 
Regulation of hepatic development, metabolism, and paths towards cancer.
Mentorship Development: 

4/12/19    Acknowledging and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Parnassus)
12/12/19    ACRA: Setting Training Expectations for Trainees on the Academic Career Track (1.5 hours)
10/20/20    Gathering in Community: a Training for Faculty and Staff

Publications: 

AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis.

Scientific reports

Shihan MH, Sharma S, Cable C, Prathigudupu V, Chen A, Mattis AN, Chen JY

Fluoride-related changes in the fetal cord blood proteome; a pilot study.

Research square

Tuomivaara ST, Goin DE, Fisher SJ, Hall SC, Mattis AN, Den Besten PK

MicroRNAs Associated with Metformin Treatment in the Diabetes Prevention Program.

Research square

Lewis KA, Stroebel B, Zhang L, Aouizerat B, Mattis A, Flowers E

Hyperpolarized [1-13 C] pyruvate MRSI to detect metabolic changes in liver in a methionine and choline-deficient diet rat model of fatty liver disease.

Magnetic resonance in medicine

Piraquive Agudelo J, Kim Y, Agarwal S, Sriram R, Bok R, Kurhanewicz J, Mattis AN, Maher JJ, von Morze C, Ohliger MA

Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.

bioRxiv : the preprint server for biology

Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB

Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data.

PloS one

Tbeileh N, Timmerman L, Mattis AN, Toriguchi K, Kasai Y, Corvera C, Nakakura E, Hirose K, Donner DB, Warren RS, Karelehto E

Fundic Gland Polyps Lack DNA Content Abnormality Characteristic of Other Adenomatous Precursor Lesions in the Gastrointestinal Tract.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Akanuma N, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT

Transient expression of factor VIII and achronic high-fat diet induces ER stress and late hepatocyte oncogenesis.

Molecular therapy : the journal of the American Society of Gene Therapy

Pierce GF, Mattis AN

Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis.

Frontiers in medicine

Yu A, Cable C, Sharma S, Shihan MH, Mattis AN, Mileva I, Hannun YA, Duwaerts CC, Chen JY

Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease.

Cellular and molecular gastroenterology and hepatology

Muñoz A, Theusch E, Kuang YL, Nalula G, Peaslee C, Dorlhiac G, Landry MP, Streets A, Krauss RM, Iribarren C, Mattis AN, Medina MW

Clinical Application of Induced Hepatocyte-like Cells Produced from Mesenchymal Stromal Cells: A Literature Review.

Cells

Bogliotti Y, Vander Roest M, Mattis AN, Gish RG, Peltz G, Anwyl R, Kivlighn S, Schuur ER

Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A.

Nature medicine

Fong S, Yates B, Sihn CR, Mattis AN, Mitchell N, Liu S, Russell CB, Kim B, Lawal A, Rangarajan S, Lester W, Bunting S, Pierce GF, Pasi KJ, Wong WY

Doxycycline Significantly Enhances Induction of iPSCs to Endoderm by Enhancing survival via AKT Phosphorylation.

Hepatology (Baltimore, Md.)

Peaslee C, Esteva-Font C, Su T, Munoz-Howell A, Duwaerts C, Liu Z, Rao S, Liu K, Medina M, Sneddon JB, Maher JJ, Mattis AN

Persistent or recurrent Barrett's neoplasia after an endoscopic therapy session is associated with DNA content abnormality and can be detected by DNA flow cytometric analysis of paraffin-embedded tissue.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Bowman CJ, Zhang R, Balitzer D, Wang D, Rabinovitch PS, Kovári BP, Mattis AN, Kakar S, Lauwers GY, Choi WT

iPSC-derived hepatocytes from patients with nonalcoholic fatty liver disease display a disease-specific gene expression profile.

Gastroenterology

Duwaerts CC, Le Guillou D, Her CL, Phillips NJ, Willenbring H, Mattis AN, Maher JJ

Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α.

Cell death and differentiation

Duwaerts CC, Siao K, Soon RK, Her C, Iwawaki T, Kohno K, Mattis AN, Maher JJ

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.

Science translational medicine

Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY

Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.

Scientific reports

Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A

Utility of DNA flow cytometry in distinguishing between malignant and benign intrahepatic biliary lesions.

Virchows Archiv : an international journal of pathology

Wen KW, Rabinovitch PS, Wang D, Mattis AN, Ferrell LD, Choi WT

De novo somatic mutations and KRAS amplification are associated with cholangiocarcinoma in a patient with a history of choledochal cyst.

Journal of pediatric surgery

Schwab ME, Song H, Mattis A, Phelps A, Vu LT, Huang FW, Nijagal A

Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma.

JCI insight

Corbit KC, Wilson CG, Lowe D, Tran JL, Vera NB, Clasquin M, Mattis AN, Weiss EJ

Diagnosis, risk stratification, and management of ampullary dysplasia by DNA flow cytometric analysis of paraffin-embedded tissue.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Wen KW, Kim GE, Rabinovitch PS, Wang D, Mattis AN, Choi WT

Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation.

Stem cell research

Kuang YL, Munoz A, Nalula G, Santostefano KE, Sanghez V, Sanchez G, Terada N, Mattis AN, Iacovino M, Iribarren C, Krauss RM, Medina MW

Use of DNA flow cytometry in the diagnosis, risk stratification, and management of gastric epithelial dysplasia.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Wen KW, Rabinovitch PS, Huang D, Mattis AN, Lauwers GY, Choi WT

De novo formation of the biliary system by TGFß-mediated hepatocyte transdifferentiation.

Nature

Schaub JR, Huppert KA, Kurial SNT, Hsu BY, Cast AE, Donnelly B, Karns RA, Chen F, Rezvani M, Luu HY, Mattis AN, Rougemont AL, Rosenthal P, Huppert SS, Willenbring H

CD18 deficiency improves liver injury in the MCD model of steatohepatitis.

PloS one

Pierce AA, Duwaerts CC, Siao K, Mattis AN, Goodsell A, Baron JL, Maher JJ

Diffusion-weighted imaging of hyperpolarized [13 C]urea in mouse liver.

Journal of magnetic resonance imaging : JMRI

Marco-Rius I, Gordon JW, Mattis AN, Bok R, Delos Santos R, Sukumar S, Larson PEZ, Vigneron DB, Ohliger MA

A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models.

Journal of medicinal chemistry

Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR

Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5.

Journal of immunology (Baltimore, Md. : 1950)

Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC

Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.

Development (Cambridge, England)

Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, Fisher SJ

A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.

Hepatology (Baltimore, Md.)

Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H

Mouse liver repopulation with hepatocytes generated from human fibroblasts.

Nature

Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S

A ZFN/piggyBac step closer to autologous liver cell therapy.

Hepatology (Baltimore, Md.)

Mattis AN, Willenbring H

Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liver.

Human pathology

Levy M, Trivedi A, Zhang J, Miles L, Mattis AN, Kim GE, Lassman C, Anders RA, Misdraji J, Yerian LM, Xu H, Dhall D, Wang HL

Clinical diagnosis of segmental arterial mediolysis: differentiation from vasculitis and other mimics.

Arthritis care & research

Baker-LePain JC, Stone DH, Mattis AN, Nakamura MC, Fye KH

Purification and characterization of bacteriophage P22 Xis protein.

Journal of bacteriology

Mattis AN, Gumport RI, Gardner JF

IntDOT interactions with core- and arm-type sites of the conjugative transposon CTnDOT.

Journal of bacteriology

Dichiara JM, Mattis AN, Gardner JF

Integration host factor: putting a twist on protein-DNA recognition.

Journal of molecular biology

Lynch TW, Read EK, Mattis AN, Gardner JF, Rice PA

20q13.2 amplification in intraductal hyperplasia adjacent to in situ and invasive ductal carcinoma of the breast.

Virchows Archiv : an international journal of pathology

Werner M, Mattis A, Aubele M, Cummings M, Zitzelsberger H, Hutzler P, Höfler H