Aras Mattis, MD, PhD

Associate Professor
M_Path-Anatomic Path
+1 415 514-3062

Research Overview: The Mattis Lab is focused on identifying molecular mechanisms in normal human liver function as well as understanding complex diseases such as non-alcoholic fatty liver disease (NAFLD). In order to develop better models of this disease process we are using human induced pluripotent stem cells that are then differentiated to human hepatocyte like cells (iPSC-derived hepatocytes). Using a combination of these human derived in vitro hepatocyte models and mouse model systems we strive to develop an improved understanding of this disease.

In addition we have small projects to characterize cystic fibrosis liver disease, hepatocellular carcinoma, and cholangiocarcinoma. Located in the UCSF Department of Pathology, we make use of both collaborative efforts and IRB approved access to archived and fresh human tissue.

Primary Thematic Area: Developmental & Stem Cell Biology

Secondary Thematic Area: Tissue / Organ Biology & Endocrinology

Research Summary
Regulation of hepatic development, metabolism, and paths towards cancer.

Publications

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.

Science translational medicine

Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY