Jeffrey Bush, PhD

Professor

Department of Cell & Tissue Biology

+1 415 476-9459

Our lab studies basic mechanisms by which signaling between cells coordinates mammalian morphogenesis. Understanding this control has significance beyond its fundamental importance in development since birth defects are the leading cause of death for infants during the first year of life. We utilize multiple approaches based in mouse genetics to understand fundamental signaling processes as they relate to development and disease with particular foci in the craniofacial and respiratory systems. In addition to mouse genetics approaches, we utilize human ES/IPSCs, biophysical approaches, multiomics, and live imaging to understand the cellular and molecular control of morphogenesis.

Research Summary:

Signaling control of mammalian morphogenesis and congenital disease

Mentorship Development:

5/2021 - Sharpening your Mentoring Skills (SyMS)

Websites

Bush Lab

Publications:

Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest.

bioRxiv : the preprint server for biology

Casey-Clyde T, Liu SJ, Serrano JAC, Teng C, Jang YG, Vasudevan HN, Bush JO, Raleigh DR

Alternative cleavage and polyadenylation of the Ccnb1 mRNA defines accumulation of cyclin protein during the meiotic cell cycle.

Nucleic acids research

Wang X, Leung FS, Bush JO, Conti M

A Suite of Mouse Reagents for Studying Amelogenesis.

bioRxiv : the preprint server for biology

Wald T, Verma A, Cooley V, Marangoni P, Cazares O, Sharir A, Sandoval EJ, Sung D, Najibi H, Drennon TY, Bush JO, Joester D, Klein OD

Exome sequencing efficacy and phenotypic expansions involving esophageal atresia/tracheoesophageal fistula plus.

American journal of medical genetics. Part A

Sy MR, Chauhan J, Prescott K, Imam A, Kraus A, Beleza A, Salkeld L, Hosdurga S, Parker M, Vasudevan P, Islam L, Goel H, Bain N, Park SM, Mohammed S, Dieterich K, Coutton C, Satre V, Vieville G, Donaldson A, Beneteau C, Ghoumid J, Van Den Bogaert K, Boogaerts A, Boudry E, Vanlerberghe C, Petit F, Bernardini L, Torres B, Mattina T, Carli D, Mandrile G, Pinelli M, Brunetti-Pierri N, Neas K, Beddow R, Tørring PM, Faletra F, Spedicati B, Gasparini P, Mussa A, Ferrero GB, Lampe A, Lam W, Bi W, Bacino CA, Kuwahara A, Bush JO, Zhao X, Luna PN, Shaw CA, Rosenfeld JA, Scott DA