DSCB 216 Journal Clubs
DSCB journal clubs are held twice a month. First and second year DSCB students are required to present once in each of the two journal clubs. Students in their third year and beyond are encouraged to attend and participate in both.
The Developmental Biology Journal Club takes place at the Mission Bay campus. This series is student-led and is intended to be a less formal environment in which students can develop their presentation skills in a group of peers. Students in their second year and beyond are encouraged to serve as “student coaches” to help first year students prepare their presentations. Papers selected for presentation in this journal club should be recent and impactful manuscripts related to developmental biology.
The Stem Cell Journal Club takes place on the Parnassus campus, with two presenters each week. Student presenters are required to work with 1-2 faculty coaches and any number of student coaches (usually 2-3) to prepare for their presentations. Papers presented in this series should be recent and impactful manuscripts related to stem cell biology. Presentations should be ~25 minutes long with 5-10 minutes for discussion.
Wednesday, 9/25/2013
Developmental Biology Journal Club
5:30-6:30 p.m., CVRI SC314, Mission Bay
Jake Freimer (Student, Blelloch Lab)
Little LC, Tikhonov M, Gregor T. Precise Developmental Gene Expression Arises from Globally Stochastic Transcriptional Activity. Cell - 15 August 2013 (Vol. 154, Issue 4, pp. 789-800).
Friday, 10/11/2013
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus
1) Liz Wheatley (Student, Villeda Lab)
Wang S, Bates J, Li X, Schanz S, Chandler-Militello D, Levine C, Maherali N, Studer L, Hochedlinger K, Windrem M, Goldman SA.. Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination. Cell Stem Cell. 2013 Feb 7;12(2):252-64. doi: 10.1016/j.stem.2012.12.002. PMID: 23395447 Download
Coaches: Saul Villeda and David Rowitch
2) Todd Nystul (Faculty)
"Okay, but can they think?"
Lancaster MA, Renner M, Martin CA, Wenzel D, Bicknell LS, Hurles ME, Homfray T, Penninger JM, Jackson AP, Knoblich JA. Cerebral organoids model human brain development and microcephaly. Nature. 2013 Sep 19;501(7467):373-9. doi: 10.1038/nature12517. Epub 2013 Aug 28. PMID: 23995685. Download
Wednesday, 10/30/2013
Developmental Biology Journal Club
5:30-6:30 p.m.
CVRI 1st floor Main Conference, Mission Bay
James Price (First Year Student)
"Deterministic somatic cell reprogramming: generation of iPS cells with near 100% efficiency"
Rais, Yoach, et al. Deterministic direct reprogramming of somatic cells to pluripotency. Nature 502.7469 (2013): 65-70. Dowload
Student coaches: Becky Andersen and Jake Freimer
Friday, 11/8/2013
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus
1) Andy Norman (Student, Reiter Lab)
Nakaki F, Hayashi K, Ohta H, Kurimoto K, Yabuta Y, Saitou M. Induction of mouse germ-cell fate by transcription factors in vitro. Nature. 2013 Sep 12;501(7466):222-6. doi:10.1038/nature12417. Epub 2013 Aug 4. PubMed PMID: 23913270. Download
Coaches: Orion Weiner and Jeremy Reiter
2) Elliott Sherr (Faculty)
"Let's Go Crazy"
Han K et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.Nature. 2013 Oct 23. doi: 10.1038/nature12630. [Epub ahead of print] Download
Monday, 11/25/2013
Developmental Biology Journal Club
5:30-6:30 p.m., CVRI SC314, Mission Bay
Brian Yang
(DSCB First Year Student)
"Effects of depletion of p53 in breast cancer cells"
Freed-Pastor, W. et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell 148, 244-258 (2012) Download
Student Coach: Andy Norman
Friday, 12/6/2013
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus
Matt George (Student, Bruneau Lab)
Denholtz M et al. Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and polycomb proteins in genome organization. Cell Stem Cell. 2013 Nov 7;13(5):602-16. doi: 10.1016/j.stem.2013.08.013. Epub 2013 Sep 12. Download
Coaches: Benoit Bruneau and Elphege Nora
Trevor Burt (Faculty)
"The Power of Positive Selection: Antigen specificity is the key to generating mature T cells from human iPS cells"
Nishimura TS et al. Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation. Cell Stem Cell. 2013 Jan 3;12(1):114-26. Download
Friday, 1/10/2014
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus
Becky Andersen (Student, Lim Lab)
"Age is not just a number: progerin-induced aging of iPSCs"
Miller JD et al. Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging. Cell Stem Cell. 2013 Dec 5; 13(6): 691-705. Download
Coaches: Daniel Lim and Miguel Ramalho-Santos
Saul Villeda (Faculty)
"Stem Cells and Down Syndrome: Lessons about aging?"
Adorno M. et al. Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature. 2013 Sept 19; 501(7467):380-4 Download
Wednesday, 1/29/2014
Developmental Biology Journal Club
5:45 p.m., CVRI 1st floor Main Conference, Mission Bay
Sara Taylor (First Year Student)
Storer M et al. Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning. Cell. 2013 Nov 21;155(5):1119-30. Download
Student Coaches: Justin Ellis and Jake Freimer
Friday, 2/14/2014
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus
Svetlana Keylin (Student, Kajimura Lab)
“Breaking up is hard to do: mitochondrial fission contributes to brown fat thermogenesis”
Wikstrom J. D et al. (2014). Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure. EMBOJournal. doi:10.1002/embj.201385014
Coaches: Saul Villeda and Shingo Kajimura
Bassem Al-Sady (Faculty)
“How softening up your nucleus keeps you pluripotent”
Christophorou MA et al. Citrullination regulates pluripotency and histone H1 binding to chromatin. Nature. 2014 Jan 26. doi: 10.1038/nature12942
Developmental Biology Journal Club
Wednesday, February 26, 2014
5:30-6:30 p.m., CVRI 1st floor Main Conference, Mission Bay
Christina Abundis
(DSCB First Year Student)
Pauli A et al. Toddler: an embryonic signal that promotes cell movement via Apelin receptors.
Science. 2014 Feb 14;343(6172):1248636. Download
Student Coaches: Liz Wheatley and Jake Freimer
Friday, 3/14/2014
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus
Mikhail Binnewies (student)
“Put down the Axiron and pick up the estrogen! Your HSCs will thank you.”
Nakada et al. Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy. Nature. 2014 Jan 23;505(7484):555-8 Download
Coaches: Max Krummel and Diana Laird
Emin Maltepe (faculty)
"Sweat the small stuff - Early embryonic environment can affect long term health"
Rexhaj E et al. Mice generated by in vitro fertilization exhibit vascular dysfunction and shortened life span. J Clin Invest. 2013 Dec 2;123(12):5052-60. Download
Wednesday, 3/26/2014
Developmental Biology Journal Club
5:45 p.m., CVRI 1st floor Main Conference, Mission Bay
Ramsey Najm (First Year Student)
Obokata H1, Wakayama T2, Sasai Y3, Kojima K4, Vacanti MP5, Niwa H6, Yamato M7, Vacanti CA4. Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature. 2014 Jan 30;505(7485):641-7. Download
Student coaches: Jake Freimer and Justin Ellis
Friday, 4/11/2014
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus
James Price (First Year Student)
"Timing is key for SCNT"
Faculty Coach: John L. Rubenstein
Kang E, et al. Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos.
Nature. 2014 Mar 26. Download
Brian Yang (First Year Student)
"What gives sympathy to your heart?"
Faculty Coach: Saul Villeda
Nam J, et al. Coronary veins determine the pattern of sympathetic innervation in the developing heart. Development. 2013 Apr;140(7):1475-85. Download
Wednesday, 4/30/2014
Developmental Biology Journal Club
5:45 p.m., CVRI 1st floor Main Conference, Mission Bay
Elijah Martin (First Year Student)
Hudish LI et al. miR-219 Regulates Neural Precursor Differentiation by Direct Inhibition of Apical Par Polarity Proteins. Dev Cell. 2013 Nov 25;27(4):387-98 Download
Student Coaches: Jake Freimer and Justin Ellis
Friday, 5/9/2014
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus
Sara Taylor (First Year Student)
Christina Abundis (First Year Student)
Wednesday, 5/28/2014
Developmental Biology Journal Club
5:45 p.m., CVRI 1st floor Main Conference, Mission Bay
Presenter TBD
Friday, 6/13/2014
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus
Ramsey Najm (First Year Student)
Elijah Martin (First Year Student)
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2012-13 Archive
2011-12 Archive