DSCB 216 Journal Clubs

DSCB journal clubs are held twice a month. First and second year DSCB students are required to present once in each of the two journal clubs. Students in their third year and beyond are encouraged to attend and participate in both. See the DSCB Journal Club Archives in the right sidebar for past years' journal clubs.


The Wednesday Journal Club (formerly Developmental Biology) takes place at the Mission Bay campus. This series is student-led and is intended to be a less formal environment in which students can develop their presentation skills in a group of peers. Students in their second year and beyond are encouraged to serve as “student coaches” to help first year students prepare their presentations. Papers selected for presentation in this journal club should be recent and impactful manuscripts related to developmental biology.


The Friday Journal Club (formerly Stem Cell) takes place on the Parnassus campus, with two presenters each week. Student presenters are required to work with 2 faculty coaches and any number of student coaches (usually 2-3) to prepare for their presentations. Papers presented in this series should be recent and impactful manuscripts related to stem cell biology.


DSCB Journal Club Chair: Jeffrey Bush, PhD


**COVID-19 UPDATE**

All DSCB Journal Clubs will be conducted via Zoom meeting until further notice. To watch live, join the meeting via the methods below. We will be using the same meeting ID every week. You will also be able to ask questions of the presenters via Zoom. Please review our Zoom etiquette guidelines before joining the meeting.


The Zoom link and meeting password will be sent out to those on the DSCB listservs the day of every journal club. Please contact Demian Sainz if you are not already on one of our listservs.


The Zoom meetings will be recorded and uploaded to the DSCB intranet. MyAccess sign-in is required in order to view anything on the DSCB Intranet.

2019-20 Schedule

Friday, September 27, 2019 - 12:00pm - 1:30pm - Room: N-721

Todd Nystul (faculty)
"Know thy surroundings: factors that shape keratinocyte progenitor cell fate"
Box, K., Joyce, B.W., and Devenport, D. (2019). Epithelial geometry regulates spindle orientation and progenitor fate during formation of the mammalian epidermis. Elife 8.


Nicholas Elder (student)
"Putting in the Legwork: An Organoid Model of the Developing Limb Bud."
Mori, S. et al. Self-organized formation of developing appendages from murine pluripotent stem cells. Nat. Commun. 10, 3802 (2019)
Coaches: Alex Pollen and Tien Peng


Wednesday, October 9, 2019 - 5:00pm - 7:00pm - Room: MH-1407

Emily Bulger (student)
"Pesky Pescoids: How 'Self-organized symmetry breaking in zebrafish reveals feedback from morphogenesis to pattern formation'"

Trivedi V, Fulton T, Attardi A, Anlas K, Dingare C, Martinez Arias A, Steventon BJ."Self-organized symmetry breaking in zebrafish reveals feedback from morphogenesis to pattern formation" BioRxiv. 2019 Sept 14. DOI 10.1101/769257



Nicholas Elder (student)
"Shedding some light on signaling dynamics and cell fate in Drosophila"
Johnson, H. E., Shvartsman, S. Y. & Toettcher, J. E. Signaling dynamics control cell fate in the early Drosophila embryo. BioRxiv (2018). doi:10.1101/342998


Friday, October 18, 2019 - 12:00pm - 1:00pm - Room: N-721

Elphege Nora (faculty)
"A symmetric toggle switch explains the onset of random X inactivation in different mammals"
Mutzel et al., A symmetric toggle switch explains the onset of random X inactivation in different mammals. Nature Structural & Molecular Biology volume 26, pages350–360 (2019), doi:10.1038/s41594-019-0214-1

 

Brandon Chacon (student)
"When they go low, we go high"
Soldatov et al., Spatiotemporal structure of cell fate decisions in murine neural crest.Science  07 Jun 2019: Vol. 364, Issue 6444, eaas9536

Coaches: Faranak Fattahi and Alex Pollen


Friday, November 15, 2019 - 12:00pm - 1:00pm - Room: N-721

Diane Barber (faculty)
"Form supports function: connecting actin dynamics to chromatin remodeling and cell fate reprogramming"
Hu, X., Liu, Z.Z., Chen, X. et al. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Nat Commun 10, 1695 (2019)

 

Michael Mobaraki (student)
"Overtime Subtle Variability in Transcription and Methylation Arises in Mouse Muscle Stem Cells"
Hernando-Herraez et al., Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells, Nature Communications 2019 Sep 25; 10(1):4361.
Coaches: Robert Blelloch and Alex Pollen


Friday, January 17, 2020 - 12:00pm - 1:00pm - Room: N-721

Sophie Dumont (faculty)
"How mammalian oocytes build a spindle without centrosomes"
Science. 2019 Jun 28;364(6447).
A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.
So C, Seres KB, Steyer AM, Mönnich E, Clift D, Pejkovska A, Möbius W, Schuh M

 

Matthew Keefe (student)
"Got Developing Spinal Cord Circuitry? Go Fish"
Wan, Y., Wei, Z., Looger, L.L., Koyama, M., Druckmann, S., and Keller, P.J. (2019). Single-Cell Reconstruction of Emerging Population Activity in an Entire Developing Circuit. Cell 179, 355-372.e23.
Coaches: Georgia Panagiotakos and Faranak Fattahi


Friday, February 21, 2020 - 12:00pm - 1:00pm - Room: N-721

Jean Luke Campos (student)
"FGF Signaling Defines Cell Fate Boundaries in the Developing Mouse Jaw"
Roberts, R.R., et al., FGF signaling patterns cell fate at the interface between tendon and bone. Development, 2019. 146(15)
Coaches: Ralph Marcucio and Todd Nystul


Friday, March 20, 2020 - 12:00pm - 1:00pm - Room:

Thi Nguyen (student)
"Vertebrate diapause preserves organisms long term through Polycomb complex members"
Hu, Chi-Kuo, et al. "Vertebrate diapause preserves organisms long term through Polycomb complex members." Science 367.6480 (2020): 870-874.
Coaches: Todd Nystul and Guo Huang

Emily Bulger (student)
"Axial patterning in vitro: Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids."
Van den Brink, S.C., Alemany, A., van Batenburg, V. et al. Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids. Nature (2020). https://doi.org/10.1038/s41586-020-2024-3
Faculty coaches: Licia Selleri and Georgia Panagiotankos
Recorded video of the presentations can be found on the DSCB Intranet. MyAccess login is required.

 


Wednesday, April 1, 2020 - 5:00pm - 7:00pm - Room:

Aris Taychameekiatchai (student)
"Disruption of dmrt1 rescues the all-male phenotype of the cyp19a1a mutant in zebrafish – a novel insight into the roles of aromatase/estrogens in gonadal differentiation and early folliculogenesis"
Kun Wu, Weiyi Song, Zhiwei Zhang, Wei Ge Development 2020 147: dev182758 doi: 10.1242/dev.182758 Published 17 February 2020

Gugene Kang (student)
"Human Primordial Ge​rm​ Cells Are Specified from Lineage-Primed Progenitors."
Chen D, Sun N, Hou L, Kim R, Faith J, Aslanyan M, Tao Y, Zheng Y, Fu J, Liu W, Kellis M, Clark A. Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. Cell Rep. 2019 Dec 24;29(13):4568-4582.e5. doi: 10.1016/j.celrep.2019.11.083. PubMed PMID: 31875561; PubMed Central PMCID: PMC6939677.


Wednesday, April 29, 2020 - 5:00pm-7:00pm - Room:

Thi Nguyen
"Spontaneous emergence of cell-like organization in Xenopus egg extracts"
Cheng et al., 2019 https://science.sciencemag.org/content/366/6465/631.abstract


Friday, May 15, 2020 - 12:00pm - 1:00pm - Room:

Eliza Gaylord (student)
"Organoids Develop Motor Skills: Self-Organizing 3D Human Trunk Neuromuscular Organoids."
Faustino Martins et al., Self-Organizing 3D Human Trunk Neuromuscular Organoids, Cell Stem Cell (2019), https://doi.org/10.1016/j.stem.2019.12.007
Coaches: Faranak Fattahi and Andrew Brack

Reed McMullen (student)
"Scale-ing epithelial organoids"
Yorick Post et al., Snake Venom Gland Organoids, Cell (2020), https://doi.org/10.1016/j.cell.2019.11.038
Coaches: Todd McDevitt and Ophir Klein
Recorded video of the presentations can be found on the DSCB Intranet. MyAccess login is required.


Friday, June 5, 2020 - 12:00pm - 1:00pm - Room:

Aris Taychameekiatchai (student)
"Differences in biosynthetic production define potency hierarchy in colorectal cancer"
Morral et al., Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer, Cell Stem Cell (2020), https://doi.org/10.1016/j.stem.2020.04.012
Coaches: Todd Nystul and Barbara Panning

Karissa Hansen (student)
“Dynamic regulation at the Hoxd locus in the development of external genitalia” 
Amândio, A. R., Lopez-Delisle, L., Bolt, C. C., Mascrez, B., & Duboule, D. (2020). A complex regulatory landscape involved in the development of mammalian external genitals. eLife, 9, e52962. https://doi.org/10.7554/eLife.52962
Coaches: Nadav Ahituv and Yin Shen
Recorded video of the presentations can be found on the DSCB Intranet. MyAccess login is required.