DSCB journal clubs are held twice a month. First and second year DSCB students are required to present once in each of the two journal clubs. Students in their third year and beyond are encouraged to attend and participate in both. See the DSCB Journal Club Archives in the right sidebar for past years' journal clubs.
The Wednesday Journal Club (formerly Developmental Biology) takes place at the Mission Bay campus. This series is student-led and is intended to be a less formal environment in which students can develop their presentation skills in a group of peers. Students in their second year and beyond are encouraged to serve as “student coaches” to help first year students prepare their presentations. Papers selected for presentation in this journal club should be recent and impactful manuscripts related to developmental biology.
The Friday Journal Club (formerly Stem Cell) takes place on the Parnassus campus, with two presenters each week. Student presenters are required to work with 2 faculty coaches and any number of student coaches (usually 2-3) to prepare for their presentations. Papers presented in this series should be recent and impactful manuscripts related to stem cell biology.
DSCB Journal Club Chair: Jeffrey Bush, PhD
**COVID-19 UPDATE**
All DSCB Journal Clubs will be conducted via Zoom meeting until further notice. You will also be able to ask questions of the presenters via Zoom. Please review our Zoom etiquette guidelines before joining the meeting.
The Zoom link and meeting password will be sent out to those on the DSCB listservs the day of every journal club. Please contact Demian Sainz if you are not already on one of our listservs.
The Zoom meetings will be recorded and uploaded to the DSCB intranet. MyAccess sign-in is required in order to view anything on the DSCB Intranet.
2020-21 Schedule
The schedule for the 2020-21 academic year will be updated here shortly. See the DSCB Journal Club Archives in the right sidebar for past years' journal clubs.
Friday, October 2, 2020 - 12:00pm - 1:00pm - Room: Zoom
Sam Pleasure (faculty)
"How to tame PANDAS"
Xu J, Liu RJ, Fahey S, et al. Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity. The American Journal of Psychiatry. 2020 Jun:appiajp202019070698. DOI: 10.1176/appi.ajp.2020.19070698.
Reed McMullen (student)
"Organoid Brain Washing"
Pellegrini L, Bonfio C, Chadwick J, Begum F, Skehel M, Lancaster MA. Human CNS barrier-forming organoids with cerebrospinal fluid production. Science. 2020;369(6500):eaaz5626. doi:10.1126/science.aaz5626
Coaches: Deepak Lamba and Saul Villeda
Wednesday, October 7, 2020 - 5:00pm - 7:00pm - Room: Zoom
Christopher Chen (student)
"When life gives you lemons.... make more tentacles"
Ikmi, A., Steenbergen, P.J., Anzo, M. et al. Feeding-dependent tentacle development in the sea anemone Nematostella vectensis. Nat Commun 11, 4399 (2020). https://doi.org/10.1038/s41467-020-18133-0
Karissa Hansen (student)
"Regulating the tempo of development"
Rayon T, Stamataki D, Perez-Carrasco R, et al. Species-specific pace of development is associated with differences in protein stability. Science 2020; 369(6510):eaba7667. doi: 10.1126/science.aba7667
Friday, October 23, 2020 - 12:00pm - 1:00pm - Room:
Guo Huang (faculty)
"Gold Mining Between Two Fish"
Wang W, Hu SK, Zeng A, Alegre D; Hu D, Gotting K, Ortega Granillo A, Wang Y, Robb S, Schnittker R, Zhang S, Alegre D, Li H, Ross E, Zhang N; Brunet A, Sánchez Alvarado A. 2020. Changes in Regeneration-Responsive Enhancers Shape Regenerative Capacities in Vertebrates. Science 369 (6508): eaaz3090.
Aris Taychameekiatchai (student)
“Who WIHNs in post-injury hair follicle neogenesis?”
Abbasi, S. et al. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing. Cell Stem Cell 27, 396-412.e6 (2020).
Coaches: Saul Villeda and Bruce Wang
Wednesday, October 28, 2020 - 5:00pm - 7:00pm - Room: Zoom
Elena Turkalj (student)
"Stabilization of heterochromatin by CLOCK"
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration Chuqian Liang1,2, Zunpeng Liu2,3, Moshi Song1,2,4, Wei Li5 , Zeming Wu2,3, Zehua Wang2,3, Qiaoran Wang2,6, Si Wang1,2,4,5, Kaowen Yan1,2,4, Liang Sun7 , Tomoaki Hishida8 , Yanning Cai5 , Juan Carlos Izpisua Belmonte8 , Pedro Guillen9 , Piu Chan5 , Qi Zhou2,3,4, Weiqi Zhang2,4,6,10, Jing Qu 2,3,4 and Guang-Hui Liu 1,2,4,5
Eliza Gaylord (student)
"Follicles do the wave: Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary"
Niu, Wanbao & Spradling, Allan. (2020). Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary. Proceedings of the National Academy of Sciences. 117. 202005570. 10.1073/pnas.2005570117.
Friday, November 13, 2020 - 12:00pm - 1:00pm - Room: Zoom
Elliott Sherr (faculty)
“3D excitement!!”
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome:
Khan, T.A., Revah, O., Gordon, A. et al. Neuronal defects in a human cellular model of 22q11.2 deletion syndrome. Nat Med (2020). https://doi.org/10.1038/s41591-020-1043-9
Karissa Hansen (student)
"Disentangling Polycomb-mediated transcriptional repression."
Dobrinić P, Szczurek AT, and Klose RJ. PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency. bioRxiv 2020. doi: https://doi.org/10.1101/2020.10.09.333294
Coaches: Barbara Panning and Robert Blelloch
Friday, January 15, 2021 - 12:00pm - 1:00pm - Room: Zoom
Licia Selleri (faculty)
"'EnSERT' variant alleles of the Shh limb enhancer to grow additional digits"
Kvon EZ, et al. Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants. Cell. 2020 Mar 19;180(6):1262-1271.e15. doi: 10.1016/j.cell.2020.02.031. Epub 2020 Mar 12. PMID: 32169219; PMCID: PMC7179509.
Eliza Gaylord (student)
"Taming the Teratoma: Defining the Teratoma as a Model for Multi-lineage Human Development"
McDonald D, Wu Y, Dailamy A, Tat J, Parekh U, Zhao D, Hu M, Tipps A, Zhang K, Mali P. Defining the Teratoma as a Model for Multi-lineage Human Development. Cell (2020). https://doi.org/10.1016/j.cell.2020.10.018
Coaches: Julie Sneddon and Robert Blelloch
Wednesday, January 27, 2021 - 5:00pm - 7:00pm - Room: Zoom
Ali Kalantari (student)
"Early foregut organogenesis at single-cell resolution"
Han, L., Chaturvedi, P., Kishimoto, K. et al. Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis. Nat Commun 11, 4158 (2020). https://doi.org/10.1038/s41467-020-17968-x
Reed McMullen (student)
"Functional genomics goes live"
Jin X, Simmons SK, Guo A, Shetty AS, Ko M, Nguyen L, Jokhi V, Robinson E, Oyler P, Curry N, Deangeli G, Lodato S, Levin JZ, Regev A, Zhang F, Arlotta P. In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes. Science. 2020 Nov 27;370(6520):eaaz6063. doi: 10.1126/science.aaz6063. PMID: 33243861.
Wednesday, February 10, 2021 - 5:00pm - 7:00pm - Room: Zoom
Angeline Chemel (student)
"Acne, Ezema, and Dermatitis: Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin"
Natalia A. Veniaminova, Marina Grachtchouk, Owen J. Doane, Jamie K. Peterson, David A. Quigley, Madison V. Lull, Daryna V. Pyrozhenko, Raji R. Nair, Matthew T. Patrick, Allan Balmain, Andrzej A. Dlugosz, Lam C. Tsoi, and Sunny Y. Wong. Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin, Developmental Cell (2019), https://doi.org/10.1016/j.devcel.2019.08.015
Aris Taychameekiatchai (student)
“Enhancing murine liver regeneration”
Rizvi, F., Everton, E., Smith, A.R. et al. Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA. Nat Commun 12, 613 (2021). https://doi.org/10.1038/s41467-021-20903-3
Friday, February 19, 2021 - 12:00pm - 1:00pm - Room: Zoom
Dan Wagner (faculty)
"Gene pairing as a genomic strategy for coordinating oscillatory gene expression during somitogenesis."
Zinani, Oriana Q. H., Kemal Keseroğlu, Ahmet Ay, and Ertuğrul M. Özbudak. 2021. “Pairing of Segmentation Clock Genes Drives Robust Pattern Formation.” Nature 589 (7842): 431–36.
Elena Turkalj (student)
"Cellular diversity, niche cues, and the developing human intestine."
Holloway EM, Czerwinski M, Tsai YH, Wu JH, Wu A, Childs CJ, Walton KD, Sweet CW, Yu Q, Glass I, Treutlein B, Camp JG, Spence JR. Mapping Development of the Human Intestinal Niche at Single-Cell Resolution. Cell Stem Cell. 2020 Nov 25:S1934-5909(20)30546-4. doi: 10.1016/j.stem.2020.11.008. Epub ahead of print. PMID: 33278341.
Coaches: Dan Wagner and Brian Feldman
Wednesday, March 3, 2021 - 5:00pm - 7:00pm - Room: Zoom
Bonnie Zhu (student)
"Lymphoangiocrine signals promote cardiac growth and repair"
Liu, X., De la Cruz, E., Gu, X. et al. Lymphoangiocrine signals promote cardiac growth and repair. Nature 588, 705–711 (2020). https://doi.org/10.1038/s41586-020-2998-x
Irena Roy (student)
"Fighting Aging with Metabolism: Defining the Role of Glutamine in Senescence"
Johmura Y, Yamanaka T, Omori S, Wang T, et al. Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders. Science 2021; 371(6526): 265-270. doi: 10.1126/science.abb5916
Friday, March 19, 2021 - 12:00pm - 1:00pm - Room: Zoom
Christopher Chen (student)
"Scales use waves to scale"
De Simone, A., Evanitsky, M.N., Hayden, L. et al. Control of osteoblast regeneration by a train of Erk activity waves. Nature 590, 129–133 (2021). https://doi.org/10.1038/s41586-020-03085-8
Coaches: Guo Huang and Dan Wagner
Angeline Chemel (student)
"The Enteric Nervous System can regenerate?"
The enteric nervous system in zebrafish larvae can regenerate via migration into the ablated area and proliferation of neural crest-derived cells Maria Ohno1,*, Masataka Nikaido1,*, Natsumi Horiuchi2 , Koichi Kawakami3 and Kohei Hatta1, Development (2021) 148, dev195339
Coaches: Faranak Fattahi and Guo Huang
Wednesday, March 31, 2021 - 5:00pm - 7:00pm - Room: Zoom
Emily Wolfgram (student)
"Germline Stem Cell Proliferation and Reproductive Success in Medaka."
Cystic proliferation of germline stem cells is necessary to reproductive success and normal mating behavior in medaka. Luisa F Arias Padilla, Diana C Castañeda-Cortés, Ivana F Rosa, Omar D Moreno Acosta, Ricardo S Hattori, Rafael H Nóbrega, Juan I Fernandino. eLife 2021;10:e62757 DOI: 10.7554/eLife.62757
Haley Smith (student)
"Inherent mosaicism and extensive mutation of human placentas"
Coorens, T.H.H., Oliver, T.R.W., Sanghvi, R. et al. Inherent mosaicism and extensive mutation of human placentas. Nature (2021). https://doi.org/10.1038/s41586-021-03345-1
Friday, April 16, 2021 - 12:00pm - 1:00pm - Room: Zoom
Ali Kalantari (student)
"Having a blast with stem cells: blastocyst-like structures made from hPSCs"
Yu, L., Wei, Y., Duan, J. et al. Blastocyst-like structures generated from human pluripotent stem cells. Nature 591, 620–626 (2021). https://doi.org/10.1038/s41586-021-03356-y
Coaches: Barbara Panning and Aaron Tward
Bonnie Zhu (student)
"Gpr161 ciliary pools prevent hedgehog pathway hyperactivation phenotypes specifically from lack of Gli transcriptional repression."
Sun-Hee Hwang, Bandarigoda N. Somatilaka, Kevin White, Saikat Mukhopadhyay. Gpr161 ciliary pools prevent hedgehog pathway hyperactivation phenotypes specifically from lack of Gli transcriptional repression. bioRxiv 2021. doi: https://doi.org/10.1101/2021.01.07.425654
Coaches: Thomas Nowakowski and Jeremy Reiter
Friday, May 14, 2021 - 12:00pm - 1:00pm - Room: Zoom
Haley Smith (student)
"Shapeshifting from an oval to a cup: mouse epiblast morphogenesis"
Weberling A, Zernicka-Goetz M. Trophectoderm mechanics direct epiblast shape upon embryo implantation. Cell Rep. 2021 Jan 19;34(3):108655. doi: 10.1016/j.celrep.2020.108655. PMID: 33472064; PMCID: PMC7816124.
Coaches: Daniel Wagner and Robert Blelloch
Irena Roy (student)
"Defying Waddington's landscape: in vivo reprogramming of cranial neural crest"
Zalc A, Sinha R, Gunsagar G, Wesche D, Daszczuk P, Swigot T, Weissman I, Wysocka J, et al. Reactivation of the pluripotency program precedes formation of the cranial neural crest. Science 2021; 371(6529). doi: 20.1126/science.abb4776
Coaches: Faranak Fattahi and Licia Selleri
Friday, June 4, 2021 - 12:00pm - 1:00pm - Room: Zoom
Emily Wolfgram (student)
"Regulation of oogenesis by the myoepithelium in the Drosophila ovary"
Weaver LN, Drummond-Barbosa D. Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps of Drosophila oogenesis. Development. 2021 Mar 9;148(5):dev198663. doi: 10.1242/dev.198663. PMID: 33547134; PMCID: PMC7970067.
Coaches: Todd Nystul and Diana Laird