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DSCB 216 Journal Clubs

DSCB journal clubs are held twice a month. First and second year DSCB students are required to present once in each of the two journal clubs. Students in their third year and beyond are encouraged to attend and participate in both.

The Developmental Biology Journal Club takes place at the Mission Bay campus. This series is student-led and is intended to be a less formal environment in which students can develop their presentation skills in a group of peers. Students in their second year and beyond are encouraged to serve as “student coaches” to help first year students prepare their presentations. Papers selected for presentation in this journal club should be recent and impactful manuscripts related to developmental biology.

The Stem Cell Journal Club takes place on the Parnassus campus, with two presenters each week. Student presenters are required to work with 1-2 faculty coaches and any number of student coaches (usually 2-3) to prepare for their presentations. Papers presented in this series should be recent and impactful manuscripts related to stem cell biology. Presentations should be ~25 minutes long with 5-10 minutes for discussion.

2014-15 Schedule

Friday, September 12, 2014
Stem Cell Journal Club
12:00 p.m. - 1:00 p.m Parnassus, RMB Boardroom #1041
James Price (Student, Rubenstein Lab)   
“Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells”
Shiphony Z. et al., Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells. Nature. 2014 Sep. 513: 115-119. Download
Coach: John Rubenstein)

Mike German (Faculty)

“Islet Alphabet Soup”
Chera S. et al. Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers. Nature. 2014 Aug. doi:10.1038/13633. Download

Thursday, September 25, 2014
Developmental Biology Journal Club
5:30-6:30 p.m.  Genentech Hall S201, Mission Bay  
Jake Freimer (4th year student)
Gaydos L. et al. H3K27me and PRC2 transmit a memory of repression across generations and during development. Science. 2014 Sep. 19; 345(6203):1515-18. Download
Student coaches: None

Friday, October 17, 2014
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus  
Sara Taylor (Student, Fisher Lab)
"Statin treatment rescues FGFR3 skeletal dysplasia phenotypes"
Akihiro Yamashita, et al. Nature. 2014 Sept. 513: 507-511.
Coach: Susan Fisher Download

Chelsea Bahney (Faculty)
Liu Yang et al. Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation. PNAS. 2014 Aug 19;111(33): 12097-12102. Download

Wednesday, October 22, 2014
Developmental Biology Journal Club

5:30-6:30 p.m.  Genentech Hall N114, Mission Bay  
Ashley Libby (First Year Student)
Suhong Xu et al. C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst
that Promotes Wound Repair. Dev. Cell. 2014 Oct 13; 31(1):48-60. Download
Student coach: Jake Freimer

Friday, November 14, 2014
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus  
Christina Abundis
(Student, Baraban Lab)
Jimena Andersen et al. A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells. Neuron. 2014 Sep 3;83(5):1085-97. Download
Coach: Scott Baraban

Ramsey Najm
(Student, Huang Lab)
"Cells in Gels: A three-dimensional human neural cell culture model of Alzheimer’s disease"
Se Hoon Choi et al. A three dimensional human neural cell culture model of Alzheimer’s disease.
Nature. 2014 Oct. doi: 10.1038/nature13800. [Epub ahead of print] Download
Coach: Yadong Huang

Wednesday, November 19, 2014
Developmental Biology Journal Club

5:30-6:30 p.m.  Genentech Hall 114, Mission Bay  
Akela Kuwahara (First Year Student)
“Signaling bubbles: Luminal signaling during organogenesis in zebrafish”
Durdu S., et al. Luminal signalling links cell communication to tissue architecture during organogenesis. Nature. 2014 Nov 6;515 (7525):120-4. doi: 10.1038/nature13852. Epub 2014 Oct 22. Download
Student Coach: Ramsey Najm

Friday, December 5, 2014
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus  
Brian Yang (student)
"Loss of nuclear organization can get to your head"
Satomi Ito, et al. Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction. Nature Communications.2014 Jul 18;5:4450. doi: 10.1038/ncomms5450. Download
Coach: Takashi Mikawa

Susan Fisher (faculty)
"Convergence (Notch and Hippo) Brings Divergence (Trophoblast and Inner Cell Mass)"
T. Rayon, et al. Notch and Hippo Converge on Cdx2 to Specify the Trophectoderm Lineage in the Mouse Blastocyst. Cell Press.  2014 Aug 25;30(4):410-22. doi: 10.1016/j.devcel.2014.06.019. Epub 2014 Aug 7. Download

Wednesday, December 10, 2014
Developmental Biology Journal Club

5:30-6:30 p.m.  Genentech Hall N114, Mission Bay
Hanna Kirby (First Year Student)
“Holding it together: Bone repair in neonatal mice”
Chagai Rot, et al. A Mechanical Jack-like Mechanism Drives Spontaneous Fracture Healing in Neonatal Mice. Developmental Cell. Volume 31, Issue 2, 159–170. 27 October 2014. Download
Student Coach: Andy Norman  

Friday, January 9, 2015
Stem Cell Journal Club

12:00-1:00 p.m., CVRI Bldg Room SC 159, Mission Bay (location change)  
Elijah Martin (Student, Srivastava Lab)   
"Alternative state, same F-ate"
Tonge PD et al. Divergent reprogramming routes lead to alternative stem-cell states. Nature. 2014 Dec 11;516(7530):192-7. Download
Coach: Bruce Conklin

Miguel Ramalho-Santos (Faculty)
Savić N et al. lncRNA Maturation to Initiate Heterochromatin Formation in the Nucleolus Is Required for Exit from Pluripotency in ESCs. Cell Stem Cell. 2014 Dec 4;15(6):720-34. Download

Wednesday, January 28, 2015
Developmental Biology Journal Club

5:30-6:30 p.m.  Genentech Hall 114, Mission Bay  
Buddy White (First Year Student)
“Bring out your dead: Expelling damaged cells from the developing brain”
Herrgen, L., et al. Calcium-Dependent Neuroepithelial Contractions Expel Damaged Cells from the Developing Brain, Dev. Cell, 31:5,  599-613. Download
December 2014
Student coach: Liz Wheatley

Friday, February 13, 2015
Stem Cell Journal Club

12:00-1:00 p.m., CVRI Bldg. Room SC 159, Mission Bay (location change)
Bonnie Cole (student)
Christopher Fry et al. Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia.
Nature Medicine (2015) 21, 76-80. Download
Coach: Jason Pomerantz

Tom Kornberg (faculty)
“Tethers that bind but do not hold; how preconceptions can be blinding”
Alexandre, Baena-Lopez & Vincent. Patterning and growth control by membrane-tethered Wingless. Nature (2014) 505, 180-185 Download

Thursday, February 26, 2015 ** DAY & LOCATION CHANGE**
Developmental Biology Journal Club

5:30-6:30 p.m.  Genentech Hall S202, Mission Bay  
Daniel He (First Year Student)
"Let's talk about the birds and the beaks"
Lamichhaney, S., et al. Evolution of Darwin's finches and their beaks revealed by genome sequencing. Nature, (2015) 518, 371-375 Download
Student coaches: Ramsey Najm

Friday,
March 13, 2015
Stem Cell Journal Club

12:00-1:00 p.m., RMB Boardroom #1041, Parnassus
Daniel He (student)
"Shedding light on Parkinson's disease. Or are they?"
Julius A. Steinbeck et al. Optogenetics enables functional analysis of human embryonic stem-cell derived grafts in a Parkinson's disease model. Nature Biotechnology (2015), Nature Biotechnology 33, 204–209. Download
Coach: Dan Lim
              
Scott Baraban (faculty)
"Oligos to the rescue"
Jinghua Piao, et al. Human Embryonic Stem Cell-Derived
Oligodendrocyte Progenitors Remyelinate the Brain
and Rescue Behavioral Deficits following Radiation
Cell Press (2015) 16:2, 198–210. Download

Wednesday, March 25, 2015
Developmental Biology Journal Club

5:30-6:30 p.m.  Byers Hall BH-215, Mission Bay  
Liz Wheatley
You, X. et al. Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity.
Nat Neurosci. 2015 Feb 25 doi: 10.1038/nn.3975. Download
Student coaches:

Friday, April 10, 2015
Stem Cell Journal Club

12:00-1:00 p.m., RMB Boardroom #1041, Parnassus  
Hanna Kirby (student)
“ΔNp63 and Wnt Walk Abreast in Mammary Development and Cancer"
R. Chakrabarti, et al. ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signaling. Nature Cell Biology (2014) 16, 1004-1015. Download
Coaches: Jeff Bush and Todd Nystul

Akela Kuwahara (student)
"Inhibiting differentiation, identifying disease."
S. Junankar, et al. ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.
Nat. Commun. (2015) 6:6548. doi: 10.1038/ncomms7548. Download
Coach: Sarah Knox

Wednesday, April 29, 2015
Developmental Biology Journal Club

5:30-6:30 p.m.  Genentech Hall 114, Mission Bay  
Bonnie Cole (First Year Student)
"Gattaca already? First ever genetic engineering of human embryos."
Liang P et al., CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes.  Protein Cell. 2015 Apr 18. doi: 10.1007/s13238-015-0153-5
Student coach: Andy Norman

Friday, May 8, 2015    ***Date Change:  Friday, May 15, 2015***
Stem Cell Journal Club
12:00-1:00 pm, N-729, Parnassus
Ashley Libby (student)

Ye et al. (2015), Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.  Development 142, 1407-1417. doi: 10.1242/dev.117911
Coach:  Bruce Conklin
Zena Werb (faculty)

Wednesday, May 27, 2015
Developmental Biology Journal Club

5:30-6:30 p.m.  Genentech Hall 114, Mission Bay  
Andy Norman
Student coaches:

Friday, June 12, 2015 (***DATE & LOCATION CHANGE***)
Stem Cell Journal Club

12:00-1:00 p.m., Location: N-721, Parnassus
Buddy White (student)
John Rubenstein (facutly)

ARCHIVES:
2013-14 Archive
2012-13 Archive
2011-12 Archive