DSCB 216 Journal Clubs

DSCB journal clubs are held twice a month. First and second year DSCB students are required to present once in each of the two journal clubs. Students in their third year and beyond are encouraged to attend and participate in both. See the DSCB Journal Club Archives in the right sidebar for past years' journal clubs.


The Wednesday Journal Club (formerly Developmental Biology) takes place at the Mission Bay campus. This series is student-led and is intended to be a less formal environment in which students can develop their presentation skills in a group of peers. Students in their second year and beyond are encouraged to serve as “student coaches” to help first year students prepare their presentations. Papers selected for presentation in this journal club should be recent and impactful manuscripts related to developmental biology.


The Friday Journal Club (formerly Stem Cell) takes place on the Parnassus campus, with two presenters each week. Student presenters are required to work with 2 faculty coaches and any number of student coaches (usually 2-3) to prepare for their presentations. Papers presented in this series should be recent and impactful manuscripts related to stem cell biology.


DSCB Journal Club Chair: Dan Wagner, PhD



The Zoom link and meeting password will be sent out to those on the DSCB listservs the day of every journal club. Please contact Meredith Miner if you are not already on one of our listservs.



2024-25 Schedule


Friday, October 25, 2024 - 12:00-1:30 - Room: S-214

Dan Wagner, PhD
"Evolution of novel developmental trains: fish with legs!" 
Allard, Corey A. H., Amy L. Herbert, Stephanie P. Krueger, Qiaoyi Liang, Brittany L. Walsh, Andrew L. Rhyne, Allex N. Gourlay, et al. 2024. “Evolution of Novel Sensory Organs in Fish with Legs.” Current Biology: CB 34 (19): 4349-4356.e7.

Companion Paper: Herbert, Amy L., Corey A. H. Allard, Matthew J. McCoy, Julia I. Wucherpfennig, Stephanie P. Krueger, Heidi I. Chen, Allex N. Gourlay, et al. 2024. “Ancient Developmental Genes Underlie Evolutionary Novelties in Walking Fish.” Current Biology: CB 34 (19): 4339-4348.e6.

Andrew Cesiulis (student)
"What makes a big brain?"
Barão, S. et al. (2024) ‘Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion’, Nature Communications, 15(1). doi:10.1038/s41467-024-52443-x.
Journal Club Coaches: Mercedes Paredes and Trent Watkins

Wednesday, October 30, 2024 - 5:00-7:00 - Room: MH-1407

Bivas Nag (student)
Developmental emergence of first- and higher-order thalamic neuron molecular identities
Quentin Lo Giudice, Robin J. Wagener, Philipp Abe, Laura Frangeul, Denis Jabaudon; Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development 15 September 2024; 151 (18): dev202764. doi: https://doi.org/10.1242/dev.202764

Miriam Minsk
TBD
Shahriar, S., Biswas, S., Zhao, K. et al. VEGF-A-mediated venous endothelial cell proliferation results in neoangiogenesis during neuroinflammation. Nat Neurosci 27, 1904–1917 (2024). https://doi.org/10.1038/s41593-024-01746-9

Wednesday, November 6, 2024 - 5:00-7:00 - Room: MH-1407

Gabriel Avillion
"A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells"
Li L, Bowling S, McGeary SE, et al. A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells. Cell. 2023;186(23):5183-5199.e22. doi:10.1016/j.cell.2023.09.019
 

Brindha Rathinasabapathi
"Advancement of Stem Cell Therapy for Type I Diabetes"
Wang, S., Du, Y., Zhang, B. et al. Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient. Cell (2024). https://doi.org/10.1016/j.cell.2024.09.004

Friday, November 15, 2024 - 12:00-1:30 - Room: S-214

David Booth, PhD (faculty)

"The evolution of toxic cell types"

Kitchen, Sheila A. et al. Cell, Volume 187, Issue 14, 3563 - 3584.e26

 

Francesco Dalla Ricca (student)

TBD

Iyer DP, et al. mTOR activity paces human blastocyst stage developmental progression. Cell. 2024 Sep 18:S0092-8674(24)00977-2. doi: 10.1016/j.cell.2024.08.048. Epub ahead of print. PMID: 39332412.


Journal Club Coaches: Daniel Lim, MD, PhD and Keith Mostov, MD, PhD

Wednesday, November 20, 2024 - 5:00-7:00 - Room: MH-1407

Feeling Chen (student)
"A NPAS4–NuA4 complex couples synaptic activity to DNA repair"
Pollina, E.A., Gilliam, D.T., Landau, A.T. et al. A NPAS4–NuA4 complex couples synaptic activity to DNA repair. Nature 614, 732–741 (2023). https://doi.org/10.1038/s41586-023-05711-7


Edward Valenzuela (student)
TBD
Marichal N, Péron S, Beltrán Arranz A, et al. Reprogramming astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site-deficient Ascl1. Sci Adv. 2024 Oct 25;10(43):eadl5935. doi: 10.1126/sciadv.adl5935. Epub 2024 Oct 25. PMID: 39454007; PMCID: PMC11506222.

Friday, January 17, 2025 - 12:00-1:30 - Room: S-214

Nicole Suren (student)

"Lipid metabolism is a critical regulator of embryo longevity during diapause"

Van der Weijden, V. A., Stötzel, M., Iyer, D. P., Fauler, B., Gralinska, E., Shahraz, M., Meierhofer, D., Vingron, M., Rulands, S., Alexandrov, T., Mielke, T., & Bulut-Karslioglu, A. (2024). FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy. Nature Cell Biology 2024 26:2, 26(2), 181–193. https://doi.org/10.1038/s41556-023-01325-3

Coaches: John Vaughen, PhD and Serine Avagyan, MD, PhD

Gabriel Avillion (student)

"An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung"

Dakota L. Jones et al., An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung. Science 386, eado5561 (2024). DOI: 10.1126/science.ado5561

Coaches: Saul Villeda, PhD and Alex Pollen, PhD

Moderators: Nitya Kopparapu and Brindha Rathinasabapathi

Location: Parnassus Campus, Room S-214

Wednesday, January 22, 2025 - 5:00-7:00 - Room: MH-1407

Carine Joubran (student)

"EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling"

Chiara M. Schröder, Lea Zissel, Sophie-Luise Mersiowsky, Mehmet Tekman, Simone Probst, Katrin M. Schüle, Sebastian Preissl, Oliver Schilling, H. Th. Marc Timmers, Sebastian J. Arnold, EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling, Developmental Cell, 2024,,https://doi.org/10.1016/j.devcel.2024.11.014

Mika Matera-Vatnick (student)

"From Gut to Brain: Unraveling the Microbiome and GLP-1 Agonists in Inflammation Regulation"

Wong, C. K., McLean, B. A., Baggio, L. L., Koehler, J. A., Hammoud, R., Rittig, N., Yabut, J. M., Seeley, R. J., Brown, T. J., & Drucker, D. J. (2024). Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation. Cell metabolism, 36(1), 130–143.e5. https://doi.org/10.1016/j.cmet.2023.11.009

Wednesday, February 12, 2025 - 5:00-7:00 - Room: MH-1407

Naomi Cinque

"Adipose tissue retains an epigenetic memory of obesity after weight loss"

Hinte, L.C., Castellano-Castillo, D., Ghosh, A. et al. Adipose tissue retains an epigenetic memory of obesity after weight loss. Nature 636, 457–465 (2024). https://doi.org/10.1038/s41586-024-08165-7

Friday, February 28, 2025 - 12:00-1:30 - Room: S-214

Nitya Kopparapu (student)

"Mechanisms of Lumen Expansion in Human Epiblast Models: The Role of Apical Actin and Osmotic Pressure"

Indana, D., Zakharov, A., Lim, Y., Dunn, A. R., Bhutani, N., Shenoy, V. B., & Chaudhuri, O. (2024). Lumen expansion is initially driven by apical actin polymerization followed by osmotic pressure in a human epiblast model. Cell Stem Cell, 31(5), 640–656.e8. https://doi.org/10.1016/j.stem.2024.03.016

Coaches: Diana Laird, PhD and Mark Pownall, PhD

Feeling Chen (student)

"CRISPR-Cas9 Screens reveal regulators of ageing in neural stem cells"

Ruetz, T.J., Pogson, A.N., Kashiwagi, C.M. et al. CRISPR–Cas9 screens reveal regulators of ageing in neural stem cells. Nature 634, 1150–1159 (2024). https://doi.org/10.1038/s41586-024-07972-2

Coaches: Alex Marson,MD, PhD and Betsy Crouch, MD, PhD

Moderators: Tayma Handal & Gabriel Avillion

Wednesday, March 12, 2025 - - Room: MH-1407

RIPs

Wednesday, March 12, 2025 - - Room: MH-1407

RIPs

Friday, March 14, 2025 - 12:00-1:30 - Room: S-214

Brindha Rathinasabapathi (student)

"Exploring the Role of the Immune Response in Heart Regeneration"

Goumenaki, P., Günther, S., Kikhi, K. et al. The innate immune regulator MyD88 dampens fibrosis during zebrafish heart regeneration. Nat Cardiovasc Res 3, 1158–1176 (2024). https://doi.org/10.1038/s44161-024-00538-5

Coaches: Michael Alexanian, PhD and Dan Wagner, PhD

Carine Joubran (student)

"Multi-chamber cardioids unravel human heart development and cardiac defects"

Clara Schmidt, et al. Multi-chamber cardioids unravel human heart development and cardiac defects, Cell, Volume 186, Issue 25, 2023, Pages 5587-5605.e27, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2023.10.030.

Coaches: Julie Sneddon, PhD and Faranak Fattahi, PhD

Moderators: Andrew Cesiulis & Feeling Chen

Friday, April 11, 2025 - 12:00-1:30 - Room: S-214

Bivas Nag (student)

"Evolutionary convergence of sensory circuits in the pallium of amniotes"

Eneritz Rueda-Alaña et al. ,Evolutionary convergence of sensory circuits in the pallium of amniotes.Science387,eadp3411(2025).DOI:10.1126/science.adp3411

Coaches: Mercedes Paredes, MD, PhD and Alex Pollen, PhD

Tayma Handal (student)

TBD

O'Keeffe M, Booker SA, Walsh D, Li M, et al. Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus. Nat Neurosci. 2025 Feb;28(2):268-279. doi: 10.1038/s41593-024-01833-x. Epub 2025 Jan 6. PMID: 39762658; PMCID: PMC11802452.

Coaches: Elizabeth Crouch, MD, PhD and Michael Oldham, PhD

Moderators: Naomi Cinque & Mika Matera-Vatnick

Wednesday, April 23, 2025 - - Room: MH-1407

RIPs

Wednesday, April 23, 2025 - - Room: MH-1407

RIPs

Wednesday, May 7, 2025 - - Room: MH-1407

RIPs

Wednesday, May 7, 2025 - - Room: MH-1407

RIPs

Friday, May 9, 2025 - 12:00-1:30 - Room: S-214

Speakers: Edward Valenzuela & Naomi Cinque

Moderators: Carine Joubran & Miriam Minsk

Friday, May 30, 2025 - 12:00-1:30 - Room: S-214

Speakers: Mika Matera-Vatnick & Miriam Minsk

Moderators: Edward Valenzuela & Bivas Nag