DSCB 216 Journal Clubs

DSCB journal clubs are held twice a month. First and second year DSCB students are required to present once in each of the two journal clubs. Students in their third year and beyond are encouraged to attend and participate in both. See the DSCB Journal Club Archives in the right sidebar for past years' journal clubs.

The Wednesday Journal Club (formerly Developmental Biology) takes place at the Mission Bay campus. This series is student-led and is intended to be a less formal environment in which students can develop their presentation skills in a group of peers. Students in their second year and beyond are encouraged to serve as “student coaches” to help first year students prepare their presentations. Papers selected for presentation in this journal club should be recent and impactful manuscripts related to developmental biology.

The Friday Journal Club (formerly Stem Cell) takes place on the Parnassus campus, with two presenters each week. Student presenters are required to work with 2 faculty coaches and any number of student coaches (usually 2-3) to prepare for their presentations. Papers presented in this series should be recent and impactful manuscripts related to stem cell biology.

DSCB Journal Club Chair: Dan Wagner, PhD

The Zoom link and meeting password will be sent out to those on the DSCB listservs the day of every journal club. Please contact Meredith Miner if you are not already on one of our listservs.

2023-24 Schedule

Wednesday, November 1, 2023 - 5pm - Room: MH-1407

Andrew Cesiulis (student)
"Single-cell brain organoid screening identifies developmental defects in autism"
Li, C., Fleck, J.S., Martins-Costa, C. et al. Single-cell brain organoid screening identifies developmental defects in autism. Nature 621, 373–380 (2023). https://doi.org/10.1038/s41586-023-06473-y

Wednesday, November 15, 2023 - 5pm - Room: MH-1407

Francesco Dalla Ricca (student)
"IE Human Embryos Models: big potential and even bigger ethical questions"
Oldak, B., Wildschutz, E., Bondarenko, V. et al. Complete human day 14 post-implantation embryo models from naive ES cells. Nature 622, 562–573 (2023). https://doi.org/10.1038/s41586-023-06604-5

Friday, November 17, 2023 - 12pm - Room: N-217

Elphege Nora (faculty)
"Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus"
Gjaltema et al., Molecular Cell https://www.sciencedirect.com/science/article/pii/S109727652101025X?via%3Dihub

Adriana Guajardo (student)
"Senescence is the essence of whole-body regeneration in cnidarians"
Salinas-Saavedra M, Febrimarsa, Krasovec G, Horkan HR, Baxevanis AD, Frank U. Senescence-induced cellular reprogramming drives cnidarian whole-body regeneration. Cell Rep. 2023 Jul 25;42(7):112687. doi: 10.1016/j.celrep.2023.112687. Epub 2023 Jun 30.
Coaches: David Booth, PhD & Mercedes Paredes, MD, PhD

Wednesday, January 17, 2024 - 5pm - Room: MH-1407

Nicole Suren (student)
"Transplantation of human cortical organoids into rats results in integration of human neurons into rat brain circuits and subsequent behavioral changes"
Revah, O., Gore, F., Kelley, K.W. et al. Maturation and circuit integration of transplanted human cortical organoids. Nature 610, 319–326 (2022). https://doi.org/10.1038/s41586-022-05277-w

Friday, February 16, 2024 - 12pm - Room: N-217

Rose Zhou (student)
"Neurogenesis in Mothers"
Chaker, Zayna, et al. "Pregnancy-responsive pools of adult neural stem cells for transient neurogenesis in mothers." Science 382.6673 (2023): 958-963.
Coaches: Dan Wagner, PhD & Mercedes Paredes, MD, PhD

Vasileios Papakis (student)
"Unraveling the Role of Oligodendrocyte Precursor Cell Glutamate Signaling in Development and Regeneration"
Khawaja, R. R., Agarwal, A., Fukaya, M., Jeong, H.-K., Gross, S., Gonzalez-Fernandez, E., Soboloff, J., Bergles, D. E., & Kang, S. H. (2021). GLUA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration. Cell Reports, 35(7), 109147. https://doi.org/10.1016/j.celrep.2021.109147
Coaches: Stephen Fancy, PhD, DVM & Trent Watkins, PhD

Friday, March 15, 2024 - 12pm - Room: HSW-302

Ricardo Espinosa Lima (student)
"Too Hot or Too Cold: Homeostatic Control of ECM Through Yap/Taz Mechanoepigenomics"
Jones, Dakota L., et al. "Mechanoepigenetic regulation of extracellular matrix homeostasis via Yap and Taz." Proceedings of the National Academy of Sciences 120.22 (2023): e2211947120.
Coaches: Kelsey Collins, PhD & Alexis Dang, MD

Nicole Suren (student)
"Complex morphogen signaling: Cytoneme-mediated transport of active Wnt-PCP complexes"
Zhang, C., Brunt, L., Ono, Y. et al. Cytoneme-mediated transport of active Wnt5b–Ror2 complexes in zebrafish. Nature 625, 126–133 (2024). https://doi.org/10.1038/s41586-023-06850-7
Coaches: Dan Wagner, PhD & Jeff Bush, PhD

Friday, April 12, 2024 - 12pm - Room: N-217

Tayma Handal (student)
"Cell-type differential targeting of SETDB1 prevents aberrant CTCF binding, chromatin looping, and cis-regulatory interactions"
Tam, P.L.F., Cheung, M.F., Chan, L.Y. et al. Cell-type differential targeting of SETDB1 prevents aberrant CTCF binding, chromatin looping, and cis-regulatory interactions. Nat Commun 15, 15 (2024). https://doi.org/10.1038/s41467-023-44578-0
Coaches: Elphege Nora, PhD & Faranak Fattahi, PhD

Francesco Dalla Ricca (student)
"The tail that wags the dog; how fatty acid oxidization can regulate hematopoietic stem cell capacity"
Bonora M, et al. A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate. Cell Stem Cell. 2024 Mar 7;31(3):359-377.e10. doi: 10.1016/j.stem.2024.02.004.
Coaches: Mustafa Aydogan, PhD & Todd Nystul, PhD

Friday, May 10, 2024 - 12pm - Room: N-217

Andrew Cesiulis (student)
 “A Patterned Human Neural Tube Model Using Microfluidic Gradients.” 
Xue, Xufeng, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O’Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, et al. 2024. “A Patterned Human Neural Tube Model Using Microfluidic Gradients.” Nature 628 (8007): 391–99.
Coaches: Alex Pollen, PhD & Faranak Fattahi, PhD

Nitya Kopparapu (student)
"Dynamics of human embryo development through live imaging"
Domingo-Muelas, A., et al. (2023). Human embryo live imaging reveals nuclear DNA shedding during blastocyst expansion and biopsy. Cell, 186(15). https://doi.org/10.1016/j.cell.2023.06.003
Coaches: Robert Blelloch, PhD & Dan Wagner, PhD