DSCB journal clubs are held twice a month. First and second year DSCB students are required to present once in each of the two journal clubs. Students in their third year and beyond are encouraged to attend and participate in both. See the DSCB Journal Club Archives in the right sidebar for past years' journal clubs.
The Wednesday Journal Club (formerly Developmental Biology) takes place at the Mission Bay campus. This series is student-led and is intended to be a less formal environment in which students can develop their presentation skills in a group of peers. Students in their second year and beyond are encouraged to serve as “student coaches” to help first year students prepare their presentations. Papers selected for presentation in this journal club should be recent and impactful manuscripts related to developmental biology.
The Friday Journal Club (formerly Stem Cell) takes place on the Parnassus campus, with two presenters each week. Student presenters are required to work with 2 faculty coaches and any number of student coaches (usually 2-3) to prepare for their presentations. Papers presented in this series should be recent and impactful manuscripts related to stem cell biology.
DSCB Journal Club Chair: Dan Wagner, PhD
**COVID-19 UPDATE**
Beginning 10/17/2021, Friday Journal Club will be held in-person on the Parnassus campus in N-729. Zoom will continue to be an option for those with medical restrictions.
- 75 person capacity will be enforced
- Physical distancing and masking is required at all times
- Food is not allowed inside the classroom
The Zoom link and meeting password will be sent out to those on the DSCB listservs the day of every journal club. Please contact Demian Sainz if you are not already on one of our listservs.
The Zoom meetings will be recorded and uploaded to the DSCB intranet. MyAccess sign-in is required in order to view anything on the DSCB Intranet.
2021-22 Schedule
The schedule for the 2021-22 academic year will be updated here shortly. See the DSCB Journal Club Archives in the right sidebar for past years' journal clubs.
Friday, October 1, 2021 - Noon - 1:00PM - Room: Zoom
Dan Wagner, Ph.D. (Faculty)
“Clonal bottlenecks in early human embryonic development”
Park, Seongyeol, Nanda Maya Mali, Ryul Kim, Jeong-Woo Choi, Junehawk Lee, Joonoh Lim, Jung Min Park, et al. 2021. “Clonal Dynamics in Early Human Embryogenesis Inferred from Somatic Mutation.” Nature 597 (7876): 393–97.
Bonnie Zhu (Student)
"Cell competition: barrier for interspecies chimerism".
Canbin Zheng, Yingying Hu, Masahiro Sakurai, et al. Cell competition constitutes a barrier for interspecies chimerism. Nature volume 592, pages 272–276 (2021) https://www.nature.com/articles/s41586-021-03273-0
Coaches: Dan Wagner, Ph.D. and Bjoern Schwer, M.D., Ph.D.
Wednesday, October 6, 2021 - 5:00PM - 7:00PM - Room: Zoom
Angeline Chemel (Student)
"More than meets the eye: Cse1l gene"
Blizzard LE, Menke C, Patel SD, Waclaw RR, Lachke SA, Stottmann RW. A Novel Mutation in Cse1l Disrupts Brain and Eye Development with Specific Effects on Pax6 Expression. J Dev Biol. 2021;9(3):27. Published 2021 Jul 7. doi:10.3390/jdb9030027
Lina Afonso (Student)
"Drink Your Kombucha!: Microbiota from young mice counteracts selective age-associated behavioral deficits."
Boehme, M., Guzzetta, K.E., Bastiaanssen, T.F.S. et al. Microbiota from young mice counteracts selective age-associated behavioral deficits. Nat Aging 1, 666–676 (2021). https://doi.org/10.1038/s43587-021-00093-9
Friday, October 15, 2021 - Noon - 1:00PM - Room: N-729
Sophie Dumont, Ph.D. (Faculty)
"I can’t stop pushing: a kinesin pathogenic mutation leads to chromosome segregation reversal"
Thompson AF, Blackburn PR, Babovic-Vuksanovic D, Lian JB, Klee EW, Stumpff JK. Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation. bioRxiv 10.1101/2021.09.29.462402 (2021).
Emily Wolfgram (Student)
"Fitness vs. Fecundity: The Role of Arp53D in Drosophila Development"
Schroeder, C.M., Tomlin, S.A., Mejia Natividad, I., Valenzuela, J.R., Young, J.M., & Malik, H. (2021). An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development. eLife, 10.
Coaches: Licia Selleri, M.D., Ph.D. and Leanne Jones, Ph.D.
Wednesday, October 27, 2021 - 5:00PM - 7:00PM - Room: Zoom
TBD (Student)
"Tissue culture tears: the establishment, maintenance, and characterization of lacrimal gland organoids"
Bannier-Hélaouët M, Post Y, Korving J, Trani Bustos M, et al. Exploring the human lacrimal gland using organoids and single-cell sequencing. Cell Stem Cell. 2021 Jul 1;28(7):1221-1232.e7. doi: 10.1016/j.stem.2021.02.024.
Elena Turkalj (Student)
"If it weren’t for those METTLing proteins! METTL3 mRNA methyltransferase and heterochromatin regulation"
Xu, W., Li, J., He, C. et al. METTL3 regulates heterochromatin in mouse embryonic stem cells. Nature 591, 317–321 (2021). https://doi.org/10.1038/s41586-021-03210-1
Friday, November 12, 2021 - Noon - 1:00PM - Room: N-729
Licia Selleri, M.D., Ph.D. (Faculty)
"Enhancers and Genes Hand in Hand": Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
Malkmus, J., Ramos Martins, L., Jhanwar, S. et al. Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity. Nat Commun 12, 5557 (2021). https://doi.org/10.1038/s41467-021-25810-1
Ali Kalantari (Student)
"Engineering neural tube from a sheet of hPSCs: morphogenesis in vitro by geometric constraints"
Karzbrun, E., Khankhel, A. H., Megale, H. C., Glasauer, S. M., Wyle, Y., Britton, G.,... Streichan, S. J. (2021). Human neural tube morphogenesis in vitro by geometric constraints. Nature. doi:10.1038/s41586-021-04026-9
Wednesday, November 17, 2021 - 5:00PM - 7:00PM - Room: Zoom
Ernesto Rojas (Student)
"I can't wait to meet my dads!"
Li, Z.-K., Wang, L.-Y., Wang, L.-B., Feng, G.-H., Yuan, X.-W., Liu, C., Xu, K., Li, Y.-H., Wan, H.-F., Zhang, Y., et al. (2018). Generation of bimaternal and bipaternal mice from hypomethylated haploid escs with imprinting region deletions (Cell Press). Vol 23. Iss. 5. pg. 665-676.e4
Haley Smith (Student)
"3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels"
Govindasamy et al., 3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels, Developmental Cell (2021), https://doi.org/10.1016/j.devcel.2021.10.014
Wednesday, December 1, 2021 - 5:00PM - 7:00PM - Room: Zoom
Kevin Chen (Student)
"Cell Culture Stares Back: Optic Vesicle Brain Organoids"
Elke Gabriel et al, Human brain organoids assemble functionally integrated bilateral optic vesicles, Cell Stem Cell,Volume 28, Issue 10, 2021, Pages 1740-1757.e8, ISSN 1934-5909, https://doi.org/10.1016/j.stem.2021.07.010.
Ali Kalantari (Student)
"Surface tension drives hydrodynamic instability and induces mammary ducts to form alveoli: Surface-tension-induced budding drives alveologenesis in human mammary gland organoids”
Fernández, P. A., Buchmann, B., Goychuk, A., Engelbrecht, L. K., Raich, M. K., Scheel, C. H., . . . Bausch, A. R. (2021). Surface-tension-induced budding drives alveologenesis in human mammary gland organoids. Nature Physics, 17(10), 1130-1136. doi:10.1038/s41567-021-01336-7
Friday, December 3, 2021 - Noon - 1:00PM - Room: N-729
Abby Buchwalter, PhD (Faculty)
"Putting the squeeze on cell fate"
Transient nuclear deformation primes epigenetic state and promotes cell reprogramming. Yang Song et al., BioRXiV, May 21st, 2021. doi: https://doi.org/10.1101/2021.05.19.444886.
Irena Roy (Student)
"Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration"
Costa, C., Otsuki, L., Albors, A., Tanaka, E., Chara, O. (2021). Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration. Elife, 10.
Coaches: Guo Huang and Todd Nystul
Wednesday, January 19, 2022 - 5:00PM - 7:00Pm - Room: TBD
Jaz Harris (Student)
"Derived, differentiated, delivered, it's yours!"
Woan, Karrune V., et al. "Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy." Cell Stem Cell 28.12 (2021): 2062-2075.
Christopher Chen (Student)
"ECM: it does things"
Munjal, A., Hannezo, E., Tsai, T. Y.-C., Mitchison, T. J., & Megason, S. G. (2021). Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. Cell, 184(26), 6313–6325.e18.
Friday, January 21, 2022 - Noon - 1:00PM - Room: TBD
Haley Smith (Student)
"Capturing the dynamism of the endometrium"
Garcia-Alonso, L., Handfield, LF., Roberts, K. et al. Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro. Nat Genet 53, 1698–1711 (2021).
Coaches: Susan Fisher, PhD & Barbara Panning, PhD
Ernesto Rojas (Student)
" 'Was that me or you?'- Modeling FGF4 as a population proportion organizer"
Raina, D., Bahadori, A., Stanoev, A., Protzek, M., Koseska, A., and Schröter, C. (2021). Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells. Development 148, dev199926.
Coaches: Robert Blelloch, MD, PhD & Jeremy Reiter, MD, PhD
Wednesday, February 9, 2022 - 5:00PM - 7:00PM - Room: TBD
Emma Horton (Student)
"Proof fats are good for you: the role of lipid droplets in instructing neural stem cell behavior"
Ramosaj, Mergim, Sofia Madsen, Vanille Maillard, Valentina Scandella, Daniel Sudria-Lopez, Naoya Yuizumi, Ludovic Telley, and Marlen Knobloch. 2021. “Lipid Droplet Availability Affects Neural Stem/Progenitor Cell Metabolism and Proliferation.” Nature Communications 12 (1): 7362.
Irena Roy (Student)
TBD
Friday, February 18, 2022 - Noon - 1:00PM - Room: TBD
Angeline Chemel (Student)
TBD
Lina Afonso (Student)
TBD
Friday, March 18, 2022 - Noon - 1:00PM - Room: TBD
Elena Turkalj (Student)
TBD
Kevin Chen (Student)
TBD
Friday, April 15, 2022 - Noon - 1:00PM - Room: TBD
Christopher Chen (Student)
TBD
TBD (Student)
TBD
Wednesday, April 27, 2022 - 5:00PM - 7:00PM - Room: TBD
Sneha Rao (Student)
TBD
Bonnie Zhu (Student)
TBD
Wednesday, May 11, 2022 - 5:00PM - 7:00PM - Room: TBD
Laura Shechtman (Student)
TBD
Emily Wolfgram (Student)
TBD
Friday, May 13, 2022 - Noon - 1:00PM - Room: TBD
Jaz Harris (Student)
TBD
Emma Horton (Student)
TBD
Friday, June 3, 2022 - Noon - 1:00PM - Room: TBD
Sneha Rao (Student)
TBD
Laura Shechtman (Student)
TBD