Mercedes Paredes, MD, PhD

Professor in Residence
M_Neurology

The Paredes lab studies cortical development to understand the molecular and cellular basis of neuropsychiatric conditions, such as epilepsy, and brain malformations. Our hypothesis is that the gyrencephalic brain has evolved developmental processes and a prolonged timeline that, when disrupted, will lead to cortical disorganization and aberrant connectivity. We are currently focused on identifying features of neuronal progenitor proliferation and migration, with an emphasis on the perinatal period, that are unique to the gyrated brain. Our approach is to advance ways to directly investigate the human brain and to better model its development using gyrencephalic systems like the piglet cortex.

 

Research Summary
Studying cortical development to understand the molecular and cellular basis of neuropsychiatric conditions, such as epilepsy and brain malformations.

Publications

Fate plasticity of interneuron specification.

iScience

Mostajo-Radji MA, Leon WRM, Breevoort A, Gonzalez-Ferrer J, Schweiger HE, Lehrer J, Zhou L, Schmitz MT, Perez Y, Mukhtar T, Robbins A, Chu J, Andrews MG, Sullivan FN, Tejera D, Choy EC, Paredes MF, Teodorescu M, Kriegstein AR, Alvarez-Buylla A, Pollen AA

Temporally distinct 3D multi-omic dynamics in the developing human brain.

Nature

Heffel MG, Zhou J, Zhang Y, Lee DS, Hou K, Pastor-Alonso O, Abuhanna KD, Galasso J, Kern C, Tai CY, Garcia-Padilla C, Nafisi M, Zhou Y, Schmitt AD, Li T, Haeussler M, Wick B, Zhang MJ, Xie F, Ziffra RS, Mukamel EA, Eskin E, Nowakowski TJ, Dixon JR, Pasaniuc B, Ecker JR, Zhu Q, Bintu B, Paredes MF, Luo C

Simplified risk-prediction for benchmarking and quality improvement in emergency general surgery. Prospective, multicenter, observational cohort study.

International journal of surgery (London, England)

Villodre C, Taccogna L, Zapater P, Cant? M, Mena L, Ramia JM, Llu?s F, Afonso N, Aguilella V, Aguil? J, Alados JC, Alberich M, Apio AB, Balongo R, Bra E, Bravo-Guti?rrez A, Brice?o FJ, Caba?as J, C?novas G, Caravaca I, Carbonell S, Carrera-Dacosta E, Castro EE, Caula C, Choolani-Bhojwani E, Codina A, Corral S, Cuenca C, Curbelo-Pe?a Y, Delgado-Morales MM, Delgado-Plasencia L, Dom?nech E, Est?vez AM, Feria AM, Gasc?n-Dom?nguez MA, Gianchandani R, Gonz?lez C, Hevia RJ, Gonz?lez MA, Hidalgo JM, Lainez M, Llu?s N, L?pez F, L?pez-Fern?ndez J, L?pez-Ru?z JA, Lora-Cumplido P, Madrazo Z, Marchena J, de la Cuadra MB, Mart?n S, Casas MI, Mart?nez P, Mena-Mateos A, Morales-Garc?a D, Mulas C, Mu?oz-Forner E, Naranjo A, Navarro-S?nchez A, Oliver I, Ortega I, Ortega-Higueruelo R, Ortega-Ruiz S, Osorio J, Pad?n MH, Pamies JJ, Paredes M, Pareja-Ciur? F, Parra J, P?rez-Guarin?s CV, P?rez-Saborido B, Pintor-Tortolero J, Plua-Mu?iz K, Rey M, Rodr?guez I, Ruiz C, Ru?z R, Ruiz S, S?nchez A, S?nchez D, S?nchez R, S?nchez-Cabezudo F, S?nchez-Santos R, Santos J, Serrano-Paz MP, Soria-Aledo V, Tall?n-Aguilar L, Valdivia-Risco JH, Vallverd?-Carti? H, Varela C, Villar-Del-Moral J, Zambudio N, LUCENTUM Project Researchers

Does Adult Neurogenesis Persist in the Human Hippocampus?

Cell stem cell

Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A