Ralph Marcucio, PhD

Professor
Department of Orthopaedic Surgery

First, using cutting-edge genomic technology, Dr. Marcucio is examining how the entire genome responds to orthopaedic trauma. This genome-mining approach is aimed at determining the global genome response during fracture repair and allows the possibility to generate improved, highly innovative therapies for people undergoing fracture repair. Second, Ralph is examining the role that the brain plays during normal development of the facial skeleton. Many facial birth defects have an underlying brain malformation, and the goal of the research is to generate novel therapeutic approaches that will allow correcting facial malformations prior to birth.

Research Summary: 
Craniofacial development, evolutionary biology, trauma, bone repair, angiogenesis
Publications: 

Simulation Enabled Search for Explanatory Mechanisms of the Fracture Healing Process.

bioRxiv

Ryan C. Kennedy,Meir Marmor,Ralph Marcucio,C. Anthony Hunt

Contributor contact details.

K.K. Mallick,S. Sprio,M. Sandri,M. Iafisco,A. Ruffini,S. Minardi,A. Tampieri,P. Bhattacharya,G.H. van Lenthe,E.B. Hunziker,T.J. Blokhuis,V. Guarino,M.G. Raucci,A. Ronca,V. Cirillo,L. Ambrosio,K.K. Mallick,J. Winnett,A. Bansiddhi,D.C. Dunand,G.C. Wang,Z.F. Lu,H. Zreiqat,C.S. Bahney,R.S. Marcucio,J. Venkatesan,S.K. Kim,L. Grøndahl,C.S. Goonasekera,K.S. Jack,S.A. Clarke,P. Walsh

Epigenetic integration of the developing brain and face.

Developmental Dynamics

Trish E. Parsons,Eric J. Schmidt,Julia C. Boughner,Heather A. Jamniczky,Ralph S. Marcucio,Benedikt Hallgrímsson

Cellular basis for age-related changes in fracture repair.

Journal of Orthopaedic Research®

C LU,T MICLAU,D HU,E HANSEN,K TSUI,C PUTTLITZ,R MARCUCIO