Sheng Ding, PhD

William K. Bowes Jr. Distinguished Investigator

Professor

Department of Pharmaceutical Chemistry

+1 415 734-2717

Dr. Sheng Ding is currently William K. Bowes, Jr. Distinguished Investigator and Professor at Gladstone Institute of Cardiovascular Disease, and Department of Pharmaceutical Chemistry, University of California San Francisco. He obtained his B.S. in chemistry with honors from Caltech in 1999, and a Ph.D. in chemistry from The Scripps Research Institute in 2003. Before moving to Gladstone/UCSF in early 2011, Ding was an Assistant Professor and then Associate Professor of Chemistry at Scripps from 2003 to 2011. Dr. Ding has pioneered on developing and applying innovative chemical approaches to stem cell biology and regeneration, with a focus on discovering and characterizing novel small molecules that can control various cell fate/function, including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues. Ding has published over 100 research articles, reviews and book chapters, and made several seminal contributions to the stem cell field. Ding is a cofounder of Fate Therapeutics and Stemgent.

Research Summary:

Our lab develops and uses chemical biology approaches to identify and characterize novel small molecules that modulate cell fate and function in normal or diseased states.

Publications:

A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions.

Science (New York, N.Y.)

Desai RV, Chen X, Martin B, Chaturvedi S, Hwang DW, Li W, Yu C, Ding S, Thomson M, Singer RH, Coleman RA, Hansen MMK, Weinberger LS

Scientific considerations for global drug development.

Science translational medicine

Wilson JL, Cheung KWK, Lin L, Green EAE, Porrás AI, Zou L, Mukanga D, Akpa PA, Darko DM, Yuan R, Ding S, Johnson WCN, Lee HA, Cooke E, Peck CC, Kern SE, Hartman D, Hayashi Y, Marks PW, Altman RB, Lumpkin MM, Giacomini KM, Blaschke TF

Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions.

Nature communications

Yang B, Tang S, Ma C, Li ST, Shao GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.

Stem cell reports

Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L

Brown Adipogenic Reprogramming Induced by a Small Molecule.

Cell reports

Nie B, Nie T, Hui X, Gu P, Mao L, Li K, Yuan R, Zheng J, Wang H, Li K, Tang S, Zhang Y, Xu T, Xu A, Wu D, Ding S

Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming.

Circulation

Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang YS, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D

Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine.

Cell chemical biology

Liu K, Yu C, Xie M, Li K, Ding S

Conversion of human fibroblasts into functional cardiomyocytes by small molecules.

Science (New York, N.Y.)

Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S

Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation.

Cell stem cell

Zhang M, Lin YH, Sun YJ, Zhu S, Zheng J, Liu K, Cao N, Li K, Huang Y, Ding S

Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.

Cell stem cell

Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S

Human pancreatic beta-like cells converted from fibroblasts.

Nature communications

Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S

Abstract 11415: Enhancing Direct Cardiac Reprogramming Efficiency Using Small Molecules.

Circulation

Tamer M Mohamed, Nicole Stone, Emily Berry, Haixia Wang, Sheng Ding, Deepak Srivastava

458. Sensitizing Ovarian Cancer Cells To Chemotherapy By Interfering With Pathways That Are Involved in the Formation and Maintenance of Cancer Stem Cells.

Molecular Therapy

Kamola Saydaminova, Robert Strauss, Min Xie, Charles Dreshner, Sheng Ding, Andre Lieber

Chapter 4 Chemical Approaches to Controlling Cell Fate.

Principles of Developmental Genetics

Mingliang Zhang, Ke Li, Min Xie, Sheng Ding

Chemical approaches to cell reprogramming.

Current opinion in genetics & development

Yu C, Liu K, Tang S, Ding S

Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages.

Cell stem cell

Li K, Zhu S, Russ HA, Xu S, Xu T, Zhang Y, Ma T, Hebrok M, Ding S

Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells.

Cell research

Zhu S, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang X, Zhang M, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, McKercher SR, Cho YS, Lipton SA, Kim J, Ding S