Wallace Marshall, PhD

Professor
Department of Biochemistry and Biophysics
[email protected]
+1 415 514-4304

Our lab is interested in the engineering design principles that underlie morphogenesis at the cellular level. We want to understand how the three-dimensional geometry of cells can be encoded in a one-dimensional genome and developed into varying cellular architectures under genetic control. We are investigating this question at the level of individual organelles (centrioles, cilia, and mitochondria) as well as through studies of the overall architecture of cells. We are particularly interested in the control of organelle size and copy number, and in the role of biological self-replication processes. Our lab uses a combination of genomic, proteomic, imaging, and mathematical modeling approaches.  Recently we have begun a major new effort to understand pattern formation and regeneration at the single-cell level using the giant ciliate Stentor coeruleus, which is allowing us to take a genomics-based approach to understanding the developmental biology of single cells.

Research Summary
Developmental biology of single cells
Websites
Marshall Lab

Publications

Where physics and biology meet.

Current biology : CB

Marshall W, Baum B, Fairhall A, Heisenberg CP, Koslover E, Liu A, Mao Y, Mogilner A, Nelson CM, Paluch EK, Trepat X, Yap A

Non-model model organisms.

BMC biology

Russell JJ, Theriot JA, Sood P, Marshall WF, Landweber LF, Fritz-Laylin L, Polka JK, Oliferenko S, Gerbich T, Gladfelter A, Umen J, Bezanilla M, Lancaster MA, He S, Gibson MC, Goldstein B, Tanaka EM, Hu CK, Brunet A

What determines cell size?

BMC biology

Marshall WF, Young KD, Swaffer M, Wood E, Nurse P, Kimura A, Frankel J, Wallingford J, Walbot V, Qu X, Roeder AH

The Chlamydomonas genome reveals the evolution of key animal and plant functions.

Science (New York, N.Y.)

Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB, Terry A, Salamov A, Fritz-Laylin LK, Maréchal-Drouard L, Marshall WF, Qu LH, Nelson DR, Sanderfoot AA, Spalding MH, Kapitonov VV, Ren Q, Ferris P, Lindquist E, Shapiro H, Lucas SM, Grimwood J, Schmutz J, Cardol P, Cerutti H, Chanfreau G, Chen CL, Cognat V, Croft MT, Dent R, Dutcher S, Fernández E, Fukuzawa H, González-Ballester D, González-Halphen D, Hallmann A, Hanikenne M, Hippler M, Inwood W, Jabbari K, Kalanon M, Kuras R, Lefebvre PA, Lemaire SD, Lobanov AV, Lohr M, Manuell A, Meier I, Mets L, Mittag M, Mittelmeier T, Moroney JV, Moseley J, Napoli C, Nedelcu AM, Niyogi K, Novoselov SV, Paulsen IT, Pazour G, Purton S, Ral JP, Riaño-Pachón DM, Riekhof W, Rymarquis L, Schroda M, Stern D, Umen J, Willows R, Wilson N, Zimmer SL, Allmer J, Balk J, Bisova K, Chen CJ, Elias M, Gendler K, Hauser C, Lamb MR, Ledford H, Long JC, Minagawa J, Page MD, Pan J, Pootakham W, Roje S, Rose A, Stahlberg E, Terauchi AM, Yang P, Ball S, Bowler C, Dieckmann CL, Gladyshev VN, Green P, Jorgensen R, Mayfield S, Mueller-Roeber B, Rajamani S, Sayre RT, Brokstein P, Dubchak I, Goodstein D, Hornick L, Huang YW, Jhaveri J, Luo Y, Martínez D, Ngau WC, Otillar B, Poliakov A, Porter A, Szajkowski L, Werner G, Zhou K, Grigoriev IV, Rokhsar DS, Grossman AR