Nicole DelRosso, BA | Developmental & Stem Cell Biology Program

Assistant Researcher

M_CMP (Cellular Molecular Pha)

Developing high-throughput methods to measure and manipulate protein interactions in human gene regulation.

Publications

Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways.

Nature communications

Hastings R, Aditham AK, DelRosso N, Suzuki PH, Fordyce PM

Development of compact transcriptional effectors using high-throughput measurements in diverse contexts.

Nature biotechnology

Tycko J, Van MV, DelRosso N, Ye H, Yao D, Valbuena R, Vaughan-Jackson A, Xu X, Ludwig C, Spees K, Liu K, Gu M, Khare V, Mukund AX, Suzuki PH, Arana S, Zhang C, Du PP, Ornstein TS, Hess GT, Kamber RA, Qi LS, Khalil AS, Bintu L, Bassik MC

High-throughput affinity measurements of direct interactions between activation domains and co-activators.

bioRxiv : the preprint server for biology

DelRosso N, Suzuki PH, Griffith D, Lotthammer JM, Novak B, Kocalar S, Sheth MU, Holehouse AS, Bintu L, Fordyce P

Using High-Throughput Measurements to Identify Principles of Transcriptional and Epigenetic Regulators.

Methods in molecular biology (Clifton, N.J.)

DelRosso N, Bintu L

Large-scale mapping and mutagenesis of human transcriptional effector domains.

Nature

DelRosso N, Tycko J, Suzuki P, Andrews C, Mukund A, Liongson I, Ludwig C, Spees K, Fordyce P, Bassik MC, Bintu L

High-Throughput Affinity Measurements of Transcription Factor and DNA Mutations Reveal Affinity and Specificity Determinants.

Cell systems

Aditham AK, Markin CJ, Mokhtari DA, DelRosso N, Fordyce PM

High-Throughput Discovery and Characterization of Human Transcriptional Effectors.

Cell

Tycko J, DelRosso N, Hess GT, Banerjee A, Mukund A, Van MV, Ego BK, Yao D, Spees K, Suzuki P, Marinov GK, Kundaje A, Bassik MC, Bintu L