Alzheimer's & Dementia

KLOTHO KL-VS genotype modifies the relationship between cardiorespiratory fitness and CSF biomarkers of neurodegeneration, synaptic dysfunction, and inflammation.

Alzheimer's & Dementia

Mackenzie Jarchow, Ira Driscoll, Brianne M. Breidenbach, Noah R. Cook, Catherine L. Gallagher, Sterling C. Johnson, Sanjay Asthana, Bruce P Hermann, Mark A. Sager, Kaj Blennow, Henrik Zetterberg, Cynthia M. Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Dane B. Cook, Dena B. Dubal, Ozioma C Okonkwo

Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.

Alzheimer's & Dementia

Aradhana Sachdev, Kamaljot Gil, Maria Sckaff, Alisha M Birk, Olubankole Aladesuyi Arogundade, Katherine A Brown, Runvir S Chouhan, Patrick Issagholian Lewin, Esha Patel, Kathleen Keough, Bruce Conklin, Alec ST Smith, Claire Clelland

Uncovering mechanisms of hyperexcitability in tauopathies with functional genomics.

Alzheimer's & Dementia

Steven C Boggess, Vaidehi Gandhi, Ming-Chi Tsai, Yu-Ying Chou, Jesse E. Hanson, Martin Kampmann

Exploring selective neuronal vulnerability in Alzheimer’s disease – key pathways are downregulated in vulnerable subpopulations of RORB and CDH9 excitatory neurons of the entorhinal cortex at Braak 0.

Alzheimer's & Dementia

Alexander V. Soloviev, Felipe Luiz Pereira, Renata Elaine Paraizo Leite, Claudia Kimie Suemoto, Kun Leng, Martin Kampmann, Lea T. Grinberg

Systemic Mechanisms of Brain Aging and Rejuvenation.

Alzheimer's & Dementia

Saul Villeda

KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults.

Alzheimer's & Dementia

Ira Frahmand Driscoll, Sarah Lose, Yue Ma, Barbara B. Bendlin, Catherine Gallagher, Sterling C. Johnson, Sanjay Asthana, Bruce Hermann, Mark A. Sager, Kaj Blennow, Henrik Zetterberg, Cynthia Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Dena Dubal, Ozioma C. Okonkwo

Phospholipase D3 drives microglial response to amyloid pathology in Alzheimer’s disease.

Alzheimer's & Dementia

Matthew J Rosene, Emma Danhash, Shih-Feng You, Abhirami Kannan Iyer, Simon Hsu, Mariana Acquarone de Sa Lopes, Logan Brase, Anthony Verbeck, Rita Martinez, Clare E Wallace, Zeran Li, Ping Yan, Nina Drager, Sydney M Sattler, Thomas E Mahan, Shannon L Macauley, David M. Holtzman, Bruno A. Benitez, Martin Kampmann, Carlos Cruchaga, Oscar Harari, John R Cirrito, Jin-Moo Lee, Alison Goate, Celeste M. Karch

Multiomics of iPSC-derived ApoE3- and ApoE4 astrocytes and microglia uncovers cell type specific dysregulation of immunometabolism.

Alzheimer's & Dementia

Rik van der Kant, Niek Blomberg, Lena Erlebach, Femke M Feringa, Jorin Heijneman, Sascha Koppes, Iris Daphne Kruijff, Amanda McQuade, Ricardo Miramontes, Damien Olivier-Jimenez, Aiko Robert, Leslie M. Thompson, Alessandro Ori, Deborah Kronenberg-Versteeg, Yassene Mohammed, Martin Kampmann, Martin Giera

Alzheimer’s disease risk genes modulate interferon-responsive microglia.

Alzheimer's & Dementia

Amanda McQuade, Vincent Cele Castillo, Nina Drager, Martin Kampmann

Plasma rejuvenation factor GDF11 associates with amyloid-related cognitive decline in older adults across the Alzheimer’s Disease spectrum.

Alzheimer's & Dementia

Shannon Y. Lee, Emily W. Paolillo, Rowan Saloner, Anna M VandeBunte, Gil D. Rabinovici, Renaud La Joie, Joel H. Kramer, Saul Villeda, Kaitlin B. Casaletto

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