Blood

Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia.

Blood

Kruth KA, Fang M, Shelton DN, Abu-Halawa O, Mahling R, Yang H, Weissman JS, Loh ML, Müschen M, Tasian SK, Bassik MC, Kampmann M, Pufall MA

Defining Primary Marrow Microenvironment-Induced Synthetic Lethality and Resistance for 2,684 Approved Drugs Across Molecularly Distinct Forms of Multiple Myeloma.

Blood

Megan Murnane, Eugen Dhimolea, Ruojing Li, Megan A. Bariteau, Diamond D. Wheeler, Rosemary J. Akhurst, Aaron C. Logan, Pamela Munster, Arun Wiita, Thomas G. Martin, Jeffrey L. Wolf, Jun O. Liu, Constantine S. Mitsiades, Blake T. Aftab

A booster shot to cure hemoglobinopathies.

Blood

Walters MC, MacKenzie TC

A booster shot to cure hemoglobinopathies.

Blood

Walters MC, MacKenzie TC

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.

Blood

Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S

PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells.

Blood

Seyedmehdi Shojaee, Valeria Cazzaniga, Hilde Schjerven, Maike Buchner, Christian Hurtz, Huimin Geng, Andreas Hochhaus, Giovanni Cazzaniga, Ari M Melnick, Steven M. Kornblau, Thomas G Graeber, Markus Muschen

Erk and Stat5 Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia.

Blood

Shojaee Seyedmehdi, Zhengshan Chen, Maike Buchner, Christian Hurtz, Huimin Geng, Hilde Schjerven, Lai N Chan, Phillip Koeffler, Cheryl L. Willman, Stephen Hunger, Sinisa Dovat, Elisabeth Paietta, Wolf-Karsten Hofmann, Ari M Melnick, Warren S. Alexander, Steven M. Kornblau, Markus Muschen

In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.

Blood

Derderian SC, Togarrati PP, King C, Moradi PW, Reynaud D, Czechowicz A, Weissman IL, MacKenzie TC

In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.

Blood

Derderian SC, Togarrati PP, King C, Moradi PW, Reynaud D, Czechowicz A, Weissman IL, MacKenzie TC

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