Proceedings of the National Academy of Sciences of the United States of America

Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes.

Proceedings of the National Academy of Sciences of the United States of America

Sierant MC, Jin SC, Bilguvar K, Morton SU, Dong W, Jiang W, Lu Z, Li B, López-Giráldez F, Tikhonova I, Zeng X, Lu Q, Choi J, Zhang J, Nelson-Williams C, Knight JR, Zhao H, Cao J, Mane S, Sedore SC, Gruber PJ, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor JW, King E, Wagner M, Srivastava D, Shen Y, Bernstein D, Porter GA, Newburger JW, Seidman JG, Roberts AE, Yandell M, Yost HJ, Tristani-Firouzi M, Kim R, Chung WK, Gelb BD, Seidman CE, Brueckner M, Lifton RP

Recessive genetic contribution to congenital heart disease in 5,424 probands.

Proceedings of the National Academy of Sciences of the United States of America

Dong W, Jin SC, Sierant MC, Lu Z, Li B, Lu Q, Morton SU, Zhang J, López-Giráldez F, Nelson-Williams C, Knight JR, Zhao H, Cao J, Mane S, Gruber PJ, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor JW, Cnota JF, Wagner M, Srivastava D, Bernstein D, Porter GA, Newburger J, Roberts AE, Yandell M, Yost HJ, Tristani-Firouzi M, Kim R, Seidman J, Chung WK, Gelb BD, Seidman CE, Lifton RP, Brueckner M

Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation.

Proceedings of the National Academy of Sciences of the United States of America

Asai R, Sinha S, Prakash VN, Mikawa T

Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.

Proceedings of the National Academy of Sciences of the United States of America

Jiang WI, Cao Y, Xue Y, Ji Y, Winer BY, Chandra R, Zhang XF, Zhang M, Singhal NS, Pierce JT, Chen S, Ma DK

Nr2f1 enhancers have distinct functions in controlling Nr2f1 expression during cortical development.

Proceedings of the National Academy of Sciences of the United States of America

Liu Z, Ypsilanti AR, Markenscoff-Papadimitriou E, Dickel DE, Sanders SJ, Dong S, Pennacchio LA, Visel A, Rubenstein JL

The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner.

Proceedings of the National Academy of Sciences of the United States of America

Mahmood N, Choi JH, Wu PY, Dooling SW, Watkins TA, Huang Z, Lipman J, Zhao H, Yang A, Silversmith J, Inglebert Y, Koumenis C, Sharma V, Lacaille JC, Sossin WS, Khoutorsky A, McKinney RA, Costa-Mattioli M, Sonenberg N

Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.

Proceedings of the National Academy of Sciences of the United States of America

Celona B, Salomonsson SE, Wu H, Dang B, Kratochvil HT, Clelland CD, DeGrado WF, Black BL

TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons.

Proceedings of the National Academy of Sciences of the United States of America

Zubia MV, Yong AJH, Holtz KM, Huang EJ, Jan YN, Jan LY

CaMKII autophosphorylation is the only enzymatic event required for synaptic memory.

Proceedings of the National Academy of Sciences of the United States of America

Chen X, Cai Q, Zhou J, Pleasure SJ, Schulman H, Zhang M, Nicoll RA

Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes.

Proceedings of the National Academy of Sciences of the United States of America

Rose K, Jepson T, Shukla S, Maya-Romero A, Kampmann M, Xu K, Hurley JH

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