Science (New York, N.Y.)

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.

Science (New York, N.Y.)

Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L

Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder.

Science (New York, N.Y.)

An JY, Lin K, Zhu L, Werling DM, Dong S, Brand H, Wang HZ, Zhao X, Schwartz GB, Collins RL, Currall BB, Dastmalchi C, Dea J, Duhn C, Gilson MC, Klei L, Liang L, Markenscoff-Papadimitriou E, Pochareddy S, Ahituv N, Buxbaum JD, Coon H, Daly MJ, Kim YS, Marth GT, Neale BM, Quinlan AR, Rubenstein JL, Sestan N, State MW, Willsey AJ, Talkowski ME, Devlin B, Roeder K, Sanders SJ

CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.

Science (New York, N.Y.)

Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N

Building blocks of the human brain.

Science (New York, N.Y.)

Nowakowski TJ

Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway.

Science (New York, N.Y.)

Bugaj LJ, Sabnis AJ, Mitchell A, Garbarino JE, Toettcher JE, Bivona TG, Lim WA

High-resolution comparative analysis of great ape genomes.

Science (New York, N.Y.)

Kronenberg ZN, Fiddes IT, Gordon D, Murali S, Cantsilieris S, Meyerson OS, Underwood JG, Nelson BJ, Chaisson MJP, Dougherty ML, Munson KM, Hastie AR, Diekhans M, Hormozdiari F, Lorusso N, Hoekzema K, Qiu R, Clark K, Raja A, Welch AE, Sorensen M, Baker C, Fulton RS, Armstrong J, Graves-Lindsay TA, Denli AM, Hoppe ER, Hsieh P, Hill CM, Pang AWC, Lee J, Lam ET, Dutcher SK, Gage FH, Warren WC, Shendure J, Haussler D, Schneider VA, Cao H, Ventura M, Wilson RK, Paten B, Pollen A, Eichler EE

Programming self-organizing multicellular structures with synthetic cell-cell signaling.

Science (New York, N.Y.)

Toda S, Blauch LR, Tang SKY, Morsut L, Lim WA

The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution.

Science (New York, N.Y.)

Briggs JA, Weinreb C, Wagner DE, Megason S, Peshkin L, Kirschner MW, Klein AM

Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo.

Science (New York, N.Y.)

Wagner DE, Weinreb C, Collins ZM, Briggs JA, Megason SG, Klein AM

Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development.

Science (New York, N.Y.)

Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV

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