staff

Molecular regulation of neural cell fate and circuit assembly

Defining conserved mechanisms regulating stem cell behavior and how these are altered with age and in response to chronic or acute changes in metabolism.

Studying cortical development to understand the molecular and cellular basis of neuropsychiatric conditions, such as epilepsy and brain malformations.

Normal and malignant blood cell development, including break of immune tolerance (autoimmunity) and blood cell cancer (leukemia), with a focus on transcriptional regulation.

We interrogate the genetic underpinnings of vertebrate development in health and disease, using the zebrafish embryo as a model. We use a combination of in vivo imaging, single-cell transcriptomics/bioinformatics, and CRISPR genetics.

We seek to understand how the organization of the nucleus is established, specialized across cell types, and maintained over time to influence cellular identity.

Mechanics of chromosome segregation

Calcium signaling in primary cilia during development and disease

Birth and Migration of New Neurons

We aim to elucidate previously unrecognized paracrine and endocrine signaling pathways that regulate stem cell fate and differentiation decisions that modulate body composition and metabolism.