2022-23 Schedule
Friday, September 30, 2022 - 11:30am - Room: HSW-303
Licia Selleri, MD, PhD (faculty)
“Fish go out on a limb”: Latent developmental potential to form limb-like skeletal structures in zebrafish
Hawkins MB, Henke K, Harris MP. Latent developmental potential to form limb-like skeletal structures in zebrafish. Cell. 2021 Feb 18;184(4):899-911.e13. doi: 10.1016/j.cell.2021.01.003. Epub 2021 Feb 4. PMID: 33545089.
Lauren Shechtman (student)
"Saved by the smell"
Margaret Herre, Olivia V. Goldman, Tzu-Chiao Lu, Gabriela Caballero-Vidal, Yanyan Qi, Zachary N. Gilbert, Zhongyan Gong, Takeshi Morita, Saher Rahiel, Majid Ghaninia, Rickard Ignell, Benjamin J. Matthews, Hongjie Li, Leslie B. Vosshall, Meg A. Younger, Non-canonical odor coding in the mosquito, Cell, 2022.
Coaches: David Julius, PhD & Tom Kornberg, PhD
Wednesday, October 5, 2022 - 5pm-7pm - Room: MH-1407
Aunoy Poddar (student)
Pinson, A., et al. (2022) Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals. Science, 377, 6611 DOI: 10.1126/science.abl6422
Friday, October 21, 2022 - 12pm - Room: N-217
Miguel Turrero García, PhD (postdoc- Harwell lab)
"Should one ever be where one does not belong?"
Revah, O., Gore, F., Kelley, K.W. et al. Maturation and circuit integration of transplanted human cortical organoids. Nature 610, 319–326 (2022). https://doi.org/10.1038/s41586-022-05277-w
Jaz Harris (student)
"Transforming glia into neurons cures epilepsy?"
Lentini, Célia, et al. "Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy." Cell stem cell 28.12 (2021): 2104-2121.
Coaches: Dan Lim, MD, PhD & Arturo Alvarez-Buylla, PhD
Wednesday, October 26, 2022 - 5pm-7pm - Room: MH-1407
Jonathan Ramirez (student)
Molè, M. A. et al. Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition. Cell Reports 34, 108834 2021).
Elysse Phillips (student)
“Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling”
Liu, M., Deng, W., Tang, L. et al. Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling. Nat Commun 13, 1006 (2022). https://doi.org/10.1038/s41467-022-28657-2
Wednesday, January 18, 2023 - 5pm-7pm - Room: MH-1407
Cindy Ow (student)
TBD
Friday, January 20, 2023 - 12pm - Room: N-217
Lina Afonso (student)
"Getting Our Guts in Order"
Hamnett, Ryan, et al. “Regional Cytoarchitecture of the Adult and Developing Mouse Enteric Nervous System.” Current Biology, vol. 32, no. 20, Oct. 2022, pp. 4483-4492.e5, doi:10.1016/j.cub.2022.08.030.
Coaches: Faranak Fattahi, PhD & Georgia Panagiotakos, PhD
Aunoy Poddar (student)
"Cortical columns and Protocadherin patterns: Testing lineage-dependent organization"
Lv, X., Li, S., Li, J. et al. Patterned cPCDH expression regulates the fine organization of the neocortex. Nature 612, 503–511 (2022). https://doi.org/10.1038/s41586-022-05495-2
Coaches: Daniele Canzio, PhD & Cathryn Cadwell, MD, PhD
Wednesday, February 8, 2023 - 5pm-7pm - Room: MH-1407
Christopher He (student)
"New Liver, Same You"
Heinke, P., Rost, F., Rode, J., Trus, P., Simonova, I., Lázár, E., ... & Bergmann, O. (2022). Diploid hepatocytes drive physiological liver renewal in adult humans. Cell Systems, 13(6), 499-507. https://doi.org/10.1016/j.cels.2022.05.001
Sneha Rao (student)
"Gastrulation got you in a jam? Just follow the leader"
Pinheiro D, Kardos R, Hannezo E, Heisenberg CP. Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming. Nature Physics 18, 1482–1493 (2022).
Friday, February 17, 2023 - 12pm - Room: N-217
Adriana Guajardo (student)
"Insights of skeletal integration during Axolotl limb regeneration"
Camilo Riquelme-GuzmánStephanie L TsaiKaren Carreon PazCongtin NguyenDavid OriolaMaritta SchuezJan BruguésJoshua D CurrieTatiana Sandoval-Guzmán (2022) Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration eLife 11:e79966.
https://doi.org/10.7554/eLife.79966
Coaches: Guo Huang, PhD & Ralph Marcucio, PhD
Vasileios Papakis (student)
"Modelling aging in a dish: bypassing reprogramming-associated cellular rejuvenation to better study Huntington's disease"
Oh, Y.M., Lee, S.W., Kim, W.K. et al. Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy. Nat Neurosci 25, 1420–1433 (2022). https://doi.org/10.1038/s41593-022-01185-4
Coaches: Saul Villeda, PhD & Bruce Conklin, MD
Wednesday, February 22, 2023 - 5pm-7pm - Room: MH-1407
Ricardo Espinosa Lima (student)
“Find Out How To Activate Your Muscle Stem Cells (Doctors Hate it)”
Silver, Jason S., et al. "Injury-mediated stiffening persistently activates muscle stem cells through YAP and TAZ mechanotransduction." Science Advances 7.11 (2021): eabe4501
Rose Zhou (student)
“Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development”
Su Y, Wang X, Yang Y, Chen L, Xia W, Hoi KK, Li H, Wang Q, Yu G, Chen X, Wang S, Wang Y, Xiao L, Verkhratsky A, Fancy SPJ, Yi C, Niu J. Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development. Neuron. 2023 Jan 18;111(2):190-201.e8. doi: 10.1016/j.neuron.2022.10.032. Epub 2022 Nov 15. PMID: 36384142; PMCID: PMC9922530.
Friday, February 24, 2023 - 12pm - Room: HSW-302
Emily Corrigan (student)
"Specification of leader cells during collective cell migration"
Hino N, Matsuda K, Jikko Y, Maryu G, Sakai K, Imamura R, Tsukiji S, Aoki K, Terai K, Hirashima T, Trepat X, Matsuda M. A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration. Dev Cell. 2022 Oct 10;57(19):2290-2304.e7. doi: 10.1016/j.devcel.2022.09.003. Epub 2022 Sep 28. PMID: 36174555.
Coaches: Dan Wagner, PhD & Todd Nystul, PhD
Sneha Rao (student)
"Don't be naive, turn on Rap1!"
Kim YS, Fan R, Lith SC, Dicke A, Drexler HCA, Kremer L, Kuempel-Rink N, Hekking L, Stehling M, Bedzhov I. Rap1 controls epiblast morphogenesis in sync with the pluripotency states transition. Dev Cell 57(16):1937-1956.
Coaches: Matt Kutys, PhD & Jeff Bush, PhD
Wednesday, March 8, 2023 - 5pm-7pm - Room: MH-1407
Emma Horton (student)
Research in Progress
Lina Afonso (student)
"hPSC-Derived Sacral Neural Crest Enables Rescue in a Severe Model of Hirschsprung’s Disease"
Fan, Yujie, et al. “hPSC-Derived Sacral Neural Crest Enables Rescue in a Severe Model of Hirschsprung’s Disease.” Cell Stem Cell, vol. 30, no. 3, Mar. 2023, pp. 264-282.e9, doi:10.1016/j.stem.2023.02.003
Friday, March 17, 2023 - 12pm - Room: N-217
Rose Zhou (student)
"Uncovering the Role of Microglia in Myelin Health Maintenance"
McNamara, N.B., Munro, D.A.D., Bestard-Cuche, N. et al. Microglia regulate central nervous system myelin growth and integrity. Nature 613, 120–129 (2023). https://doi.org/10.1038/s41586-022-05534-y
Coaches: Stephen Fancy, PhD, DVM & Tomasz Nowakowski, PhD
Jonathan Ramirez (student)
"Rack-ing Up the Regeneration: Antler Stem Cells Reveal Un-deer-appreciated Potential"
Qin, T. et al. A population of stem cells with strong regenerative potential discovered in deer antlers. Science 379, 840–847 (2023)
Coaches: Andrew Yang, PhD & Faranak Fattahi, PhD
Friday, March 24, 2023 - 12pm - Room: N-217
Emma Horton (student)
"Cxcr4 and Cxcl12 cooperate to guide migration of caudal ganglionic eminence derived neurons"
Venkataramanappa, S. et al. Cxcr4 and Ackr3 regulate allocation of caudal ganglionic eminence-derived interneurons to superficial cortical layers. Cell Rep. 40, 111157 (2022).
Coaches: John Rubenstein, MD, PhD & Corey Harwell, PhD
Kevin Chen (student)
"Watching paint dry: Live-cell imaging of single nucleosomes and chromatin"
Live-cell imaging uncovers the relationship between histone acetylation, transcription initiation, and nucleosome mobility Matthew N. Saxton1 , Tatsuya Morisaki1 , Diego Krapf2 , Hiroshi Kimura3,4, and Timothy J. Stasevich1,3 Biorxiv, March 3, 2023
Coaches: Robert Blelloch, MD, PhD & Daniel Wagner, PhD
Friday, April 14, 2023 - 12pm - Room: HSW-303
David Wen (student)
"From bench to bytesize — CRISPR screens on a computer chip"
Kamimoto, K., Stringa, B., Hoffmann, C.M. et al. Dissecting cell identity via network inference and in silico gene perturbation. Nature 614, 742–751 (2023). https://doi.org/10.1038/s41586-022-05688-9
Coaches: Dan Wagner, PhD & Ryan Corces, PhD
Ricardo Espinosa Lima (student)
"Changing Geometry With Hox Genes: A Genetic and Physical Story"
Hox genes modulate physical forces to differentially shape small and large intestinal epithelia Hasreet K. Gill, Sifan Yin, Nandan L. Nerurkar, John C. Lawlor, Tyler R. Huycke, L. Mahadevan, Clifford J. Tabin bioRxiv 2023.03.15.532602; doi: https://doi.org/10.1101/2023.03.15.532602
Coaches: Jeremy Reiter, MD, PhD & Michael Kattah, MD, PhD
Wednesday, May 10, 2023 - 5pm-7pm - Room: MH-1407
David Wen (student)
TBD
Vasileios Papakis (student)
TBD
Friday, May 12, 2023 - 12pm - Room: HSW-303
Jay Zussman (student)
"Encoding Chronological Cellular Event Histories with DNA Typewriter"
Hamazaki, N., Shendure, J., Choi, J., Chen, W., Minkina, A., Chardon, F. M., Suiter, C. C., Regalado, S. G., Domcke, S., Lee, C., Martin, B. & Daza, R. M. (2022). A time-resolved, multi-symbol molecular recorder via sequential genome editing. Nature, 1–10. https://doi.org/10.1038/s41586-022-04922-8
Coaches: Serine Avagyan, MD, PhD & Tomasz Nowakowski, PhD
Cindy Ow (student)
"The perks of periodic ppERK inhibition"
Simsek, M.F., Chandel, A.S., Saparov, D. et al. Periodic inhibition of Erk activity drives sequential somite segmentation. Nature 613, 153–159 (2023). https://doi.org/10.1038/s41586-022-05527-x
Coaches: Mustafa Aydogan, PhD & Orion Weiner, PhD
Wednesday, May 24, 2023 - 5pm-7pm - Room: MH-1407
Adriana Guajardo (student)
"The evolution of multicellularity through environmental adaptations"
Cornwallis, C.K., Svensson-Coelho, M., Lindh, M. et al. Single-cell adaptations shape evolutionary transitions to multicellularity in green algae. Nat Ecol Evol (2023). https://doi.org/10.1038/s41559-023-02044-6
Karissa Hansen (student)
"Investigating the role of DNA loop extrusion in transcriptional regulation"
Nora Lab
Friday, June 9, 2023 - 12pm - Room:
Christopher He (student)
"Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution"
Woych, J., Ortega Gurrola, A., Deryckere, A., Jaeger, E. C., Gumnit, E., Merello, G., ... & Tosches, M. A. (2022). Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution. Science, 377(6610), eabp9186. https://doi.org/10.1126/science.abp9186
Coaches: Dan Wagner, PhD & Alex Pollen, PhD
Elysse Phillips (student)
"Into the Matrix: ECM-Integrin Effects in Early Embryogenesis"
Kim, E. J. Y., Sorokin, L., & Hiiragi, T. (2022). ECM-integrin signalling instructs cellular position sensing to pattern the early mouse embryo. Development (Cambridge, England), 149(1), dev200140. https://doi.org/10.1242/dev.200140
Coaches: Matt Kutys, PhD & Jeff Bush, PhD