2021-22 Schedule
The schedule for the 2021-22 academic year will be updated here shortly. See the DSCB Journal Club Archives in the right sidebar for past years' journal clubs.
Friday, October 1, 2021 - Noon - 1:00PM - Room: Zoom
Dan Wagner, Ph.D. (Faculty)
“Clonal bottlenecks in early human embryonic development”
Park, Seongyeol, Nanda Maya Mali, Ryul Kim, Jeong-Woo Choi, Junehawk Lee, Joonoh Lim, Jung Min Park, et al. 2021. “Clonal Dynamics in Early Human Embryogenesis Inferred from Somatic Mutation.” Nature 597 (7876): 393–97.
Bonnie Zhu (Student)
"Cell competition: barrier for interspecies chimerism".
Canbin Zheng, Yingying Hu, Masahiro Sakurai, et al. Cell competition constitutes a barrier for interspecies chimerism. Nature volume 592, pages 272–276 (2021) https://www.nature.com/articles/s41586-021-03273-0
Coaches: Dan Wagner, Ph.D. and Bjoern Schwer, M.D., Ph.D.
Wednesday, October 6, 2021 - 5:00PM - 7:00PM - Room: Zoom
Angeline Chemel (Student)
"More than meets the eye: Cse1l gene"
Blizzard LE, Menke C, Patel SD, Waclaw RR, Lachke SA, Stottmann RW. A Novel Mutation in Cse1l Disrupts Brain and Eye Development with Specific Effects on Pax6 Expression. J Dev Biol. 2021;9(3):27. Published 2021 Jul 7. doi:10.3390/jdb9030027
Lina Afonso (Student)
"Drink Your Kombucha!: Microbiota from young mice counteracts selective age-associated behavioral deficits."
Boehme, M., Guzzetta, K.E., Bastiaanssen, T.F.S. et al. Microbiota from young mice counteracts selective age-associated behavioral deficits. Nat Aging 1, 666–676 (2021). https://doi.org/10.1038/s43587-021-00093-9
Friday, October 15, 2021 - Noon - 1:00PM - Room: N-729
Sophie Dumont, Ph.D. (Faculty)
"I can’t stop pushing: a kinesin pathogenic mutation leads to chromosome segregation reversal"
Thompson AF, Blackburn PR, Babovic-Vuksanovic D, Lian JB, Klee EW, Stumpff JK. Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation. bioRxiv 10.1101/2021.09.29.462402 (2021).
Emily Wolfgram (Student)
"Fitness vs. Fecundity: The Role of Arp53D in Drosophila Development"
Schroeder, C.M., Tomlin, S.A., Mejia Natividad, I., Valenzuela, J.R., Young, J.M., & Malik, H. (2021). An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development. eLife, 10.
Coaches: Licia Selleri, M.D., Ph.D. and Leanne Jones, Ph.D.
Wednesday, October 27, 2021 - 5:00PM - 7:00PM - Room: Zoom
TBD (Student)
"Tissue culture tears: the establishment, maintenance, and characterization of lacrimal gland organoids"
Bannier-Hélaouët M, Post Y, Korving J, Trani Bustos M, et al. Exploring the human lacrimal gland using organoids and single-cell sequencing. Cell Stem Cell. 2021 Jul 1;28(7):1221-1232.e7. doi: 10.1016/j.stem.2021.02.024.
Elena Turkalj (Student)
"If it weren’t for those METTLing proteins! METTL3 mRNA methyltransferase and heterochromatin regulation"
Xu, W., Li, J., He, C. et al. METTL3 regulates heterochromatin in mouse embryonic stem cells. Nature 591, 317–321 (2021). https://doi.org/10.1038/s41586-021-03210-1
Friday, November 12, 2021 - Noon - 1:00PM - Room: N-729
Licia Selleri, M.D., Ph.D. (Faculty)
"Enhancers and Genes Hand in Hand": Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
Malkmus, J., Ramos Martins, L., Jhanwar, S. et al. Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity. Nat Commun 12, 5557 (2021). https://doi.org/10.1038/s41467-021-25810-1
Ali Kalantari (Student)
"Engineering neural tube from a sheet of hPSCs: morphogenesis in vitro by geometric constraints"
Karzbrun, E., Khankhel, A. H., Megale, H. C., Glasauer, S. M., Wyle, Y., Britton, G.,... Streichan, S. J. (2021). Human neural tube morphogenesis in vitro by geometric constraints. Nature. doi:10.1038/s41586-021-04026-9
Wednesday, November 17, 2021 - 5:00PM - 7:00PM - Room: Zoom
Ernesto Rojas (Student)
"I can't wait to meet my dads!"
Li, Z.-K., Wang, L.-Y., Wang, L.-B., Feng, G.-H., Yuan, X.-W., Liu, C., Xu, K., Li, Y.-H., Wan, H.-F., Zhang, Y., et al. (2018). Generation of bimaternal and bipaternal mice from hypomethylated haploid escs with imprinting region deletions (Cell Press). Vol 23. Iss. 5. pg. 665-676.e4
Haley Smith (Student)
"3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels"
Govindasamy et al., 3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels, Developmental Cell (2021), https://doi.org/10.1016/j.devcel.2021.10.014
Wednesday, December 1, 2021 - 5:00PM - 7:00PM - Room: Zoom
Kevin Chen (Student)
"Cell Culture Stares Back: Optic Vesicle Brain Organoids"
Elke Gabriel et al, Human brain organoids assemble functionally integrated bilateral optic vesicles, Cell Stem Cell,Volume 28, Issue 10, 2021, Pages 1740-1757.e8, ISSN 1934-5909, https://doi.org/10.1016/j.stem.2021.07.010.
Ali Kalantari (Student)
"Surface tension drives hydrodynamic instability and induces mammary ducts to form alveoli: Surface-tension-induced budding drives alveologenesis in human mammary gland organoids”
Fernández, P. A., Buchmann, B., Goychuk, A., Engelbrecht, L. K., Raich, M. K., Scheel, C. H., . . . Bausch, A. R. (2021). Surface-tension-induced budding drives alveologenesis in human mammary gland organoids. Nature Physics, 17(10), 1130-1136. doi:10.1038/s41567-021-01336-7
Friday, December 3, 2021 - Noon - 1:00PM - Room: N-729
Abby Buchwalter, PhD (Faculty)
"Putting the squeeze on cell fate"
Transient nuclear deformation primes epigenetic state and promotes cell reprogramming. Yang Song et al., BioRXiV, May 21st, 2021. doi: https://doi.org/10.1101/2021.05.19.444886.
Irena Roy (Student)
"Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration"
Costa, C., Otsuki, L., Albors, A., Tanaka, E., Chara, O. (2021). Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration. Elife, 10.
Coaches: Guo Huang and Todd Nystul
Wednesday, January 19, 2022 - 5:00PM - 7:00Pm - Room: TBD
Jaz Harris (Student)
"Derived, differentiated, delivered, it's yours!"
Woan, Karrune V., et al. "Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy." Cell Stem Cell 28.12 (2021): 2062-2075.
Christopher Chen (Student)
"ECM: it does things"
Munjal, A., Hannezo, E., Tsai, T. Y.-C., Mitchison, T. J., & Megason, S. G. (2021). Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. Cell, 184(26), 6313–6325.e18.
Friday, January 21, 2022 - Noon - 1:00PM - Room: TBD
Haley Smith (Student)
"Capturing the dynamism of the endometrium"
Garcia-Alonso, L., Handfield, LF., Roberts, K. et al. Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro. Nat Genet 53, 1698–1711 (2021).
Coaches: Susan Fisher, PhD & Barbara Panning, PhD
Ernesto Rojas (Student)
" 'Was that me or you?'- Modeling FGF4 as a population proportion organizer"
Raina, D., Bahadori, A., Stanoev, A., Protzek, M., Koseska, A., and Schröter, C. (2021). Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells. Development 148, dev199926.
Coaches: Robert Blelloch, MD, PhD & Jeremy Reiter, MD, PhD
Wednesday, February 9, 2022 - 5:00PM - 7:00PM - Room: TBD
Emma Horton (Student)
"Proof fats are good for you: the role of lipid droplets in instructing neural stem cell behavior"
Ramosaj, Mergim, Sofia Madsen, Vanille Maillard, Valentina Scandella, Daniel Sudria-Lopez, Naoya Yuizumi, Ludovic Telley, and Marlen Knobloch. 2021. “Lipid Droplet Availability Affects Neural Stem/Progenitor Cell Metabolism and Proliferation.” Nature Communications 12 (1): 7362.
Irena Roy (Student)
"Another regeneration story"
Nogueira-Rodrigues J., et al. "Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection." Dev Cell 57, 1-11 (2022).
Friday, February 18, 2022 - Noon - 1:00PM - Room: N-721
Angeline Chemel (Student)
"Metabolism, Mitochondria, and Mitophagy's Role in Differentiation"
Krantz, S., Kim, Y.-M., Srivastava, S., Leasure, J. W., Toth, P. T., Marsboom, G., & Rehman, J. (2021). Mitophagy mediates metabolic reprogramming of induced pluripotent stem cells undergoing endothelial differentiation. Journal of Biological Chemistry, 297(6), 101410. https://doi.org/https://doi.org/10.1016/j.jbc.2021.101410
Coaches: Georgia Panagiotakos, PhD & Todd Nystul, PhD
Lina Afonso (Student)
"Bridging the 'gap' in hyaline cartilage regeneration"
Ling Yu, Yu-Lieh Lin, Mingquan Yan, Tao Li, Emily Y. Wu, Katherine Zimmel, Osama Qureshi, Alyssa Falck, Kirby M. Sherman, Shannon S. Huggins, Daniel Osorio Hurtado, Larry J. Suva, Dana Gaddy, James Cai, Regina Brunauer, Lindsay A. Dawson, Ken Muneoka; Hyaline cartilage differentiation of fibroblasts in regeneration and regenerative medicine. Development 15 January 2022; 149 (2): dev200249 https://doi.org/10.1242/dev.200249
Coaches: Guo Huang, PhD & Licia Selleri, MD, PhD
Friday, March 18, 2022 - Noon - 1:00PM - Room: TBD
Elena Turkalj (Student)
"RNA modifications altering time. How an rRNA methylator influences the temporal progression of neural stem cells"
Wu, Q., Shichino, Y., Abe, T. et al. Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells. Nat Commun 13, 470 (2022). https://doi.org/10.1038/s41467-022-28097-y
Coaches: Caroline Vissers, PhD & Michael Oldham, PhD
Kevin Chen (Student)
“Another expensive and hard to analyze -omic technique: Spatial Epitranscriptomics”
Deng Y, Bartosovic M, Kukanja P, Zhang D, Liu Y, Su G, Enninful A, Bai Z, Castelo-Branco G, Fan R. Spatial-CUT&Tag: Spatially resolved chromatin modification profiling at the cellular level. Science. 2022 Feb 11;375(6581):681-686. doi: 10.1126/science.abg7216. Epub 2022 Feb 10. PMID: 35143307.
Coaches: Elphege Nora, PhD & Daniel Wagner, PhD
Friday, April 15, 2022 - Noon - 1:00PM - Room: TBD
Christopher Chen (Student)
"beans go vroom"
Iwata, R., Casimir, P., Erkol, E., Boubakar, L., Planque, M., Ditkowska, M., Vints, K., Poovathingal, S., Gaspariunaite, V., Bird, M., Corthout, N., Vermeersch, P., Davie, K., Gounko, N. V., Aerts, S., Ghesquière, B., Fendt, S.-M., & Vanderhaeghen, P. (2021). Species-specific mitochondria dynamics and metabolism regulate the timing of neuronal development. In bioRxiv (p. 2021.12.27.474246). https://doi.org/10.1101/2021.12.27.474246
Coaches: Alex Pollen, PhD & Dan Wagner, PhD
Emily Corrigan(Student)
"Modeling human blastocyst development in vitro"
Kagawa, H., Javali, A., Khoei, H.H. et al. Human blastoids model blastocyst development and implantation. Nature 601, 600–605 (2022). https://doi.org/10.1038/s41586-021-04267-8
Coaches: Alex Pollen, PhD & Guo Huang, PhD
Wednesday, April 27, 2022 - 5:00PM - 7:00PM - Room: TBD
Sneha Rao (Student)
"Late bloomers - a secondary phase of blood vessel development"
Metikala, S, Warkala, M, Chetty, SC, Chestnut, B, Florat, DF, Plender, E, Nester, O, Koenig, AL, Astrof, S, Sumanas, S. 2022. Integration of vascular progenitors into functional blood vessels represents a distinct mechanism of vascular growth. Dev Cell 57(6):767-782.
Bonnie Zhu (Student)
"New era to induced pluripotency"
Guan, J., Wang, G., Wang, J. et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature (2022). https://doi.org/10.1038/s41586-022-04593-5
Wednesday, May 11, 2022 - 5:00PM - 7:00PM - Room: TBD
Lauren Shechtman (Student)
"Live coverage of a novel model of cell division"
Chan, K.Y., Yan, CC.S., Roan, HY. et al. Skin cells undergo asynthetic fission to expand body surfaces in zebrafish. Nature (2022). https://doi.org/10.1038/s41586-022-04641-0
Emily Wolfgram (Student)
"Warm and cold temperatures have distinct germline stem cell lineage effects during Drosophila oogenesis."
Gandara, A. C. P. & Drummond-Barbosa, D. Warm and cold temperatures have distinct germline stem cell lineage effects during Drosophila oogenesis. Development 149, (2022)
Friday, May 13, 2022 - Noon - 1:00PM - Room: HSW-301
Jaz Harris (Student)
"Two is better than one - fused brain organoids to model Rett syndrome"
Samarasinghe, R.A., Miranda, O.A., Buth, J.E. et al. Identification of neural oscillations and epileptiform changes in human brain organoids. Nat Neurosci 24, 1488–1500 (2021). https://doi.org/10.1038/s41593-021-00906-5
Coaches: Mercedes Paredes, MD, PhD & Tomasz Nowakowski, PhD
Lauren Shechtman (Student)
"Roadmap of human blood stem cell development"
Calvanese, V., Capellera-Garcia, S., Ma, F. et al. Mapping human haematopoietic stem cells from haemogenic endothelium to birth. Nature 604, 534–540 (2022). https://doi.org/10.1038/s41586-022-04571-x
Coaches: Barbara Panning, PhD & Hilde Schjerven, PhD
Friday, June 3, 2022 - Noon - 1:00PM - Room: HSW-301
Sneha Rao (Student)
"The key to your identity: How c-Maf unlocks liver endothelial cell fate"
Gómez-Salinero, JM, Izzo, F, Yang, L, … , Landau, DA, Schwartz, RE, Rafii, S. 2022. Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction. Cell Stem Cell 29(4): 593-609.
Coaches: Bruce Wang, MD & Dan Wagner, PhD
Emma Horton (Student)
"The role of cohesin in post-mitotic neural gene regulation"
Calderon, Lesly, Felix D Weiss, Jonathan A Beagan, Marta S Oliveira, Radina Georgieva, Yi-Fang Wang, Thomas S Carroll, et al. 2022. “Cohesin-Dependence of Neuronal Gene Expression Relates to Chromatin Loop Length.” Edited by Jeremy J Day and Kevin Struhl. ELife 11 (April): e76539. https://doi.org/10.7554/eLife.76539.
Coaches: Mercedes Paredes, MD, PhD & Elphege Nora, PhD