DSCB Journal Clubs Archive 2015-16

Friday, September 11, 2015

Stem Cell Journal Club
12:00 p.m. - 1:00 p.m, RMB Boardroom, RMB-1041, Parnassus
Buddy White (2nd year student)
"Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease."
Hamilton L et al. 2015. Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease. Cell Stem Cell, In press. 27 August, ISSN 1934-5909. doi.org/10.1016/j.stem.2015.08.001
Coaches: Yadong Huang and Georgia Panagiotakos

Andrew Brack (faculty)
"Skeletal muscle regeneration and aging."
Rodgers T, et al. mTorc1 controls the adaptive transition of quiescent stem cells from G0 to G Alert. Nature. 2014. Jun 19; 510 (7505): 393-396. doi:10.1038/nature13255.

Wednesday, September 30, 2016

Developmental Biology Journal Club
5:30-6:30 p.m.  Genentech Hall N-114, Mission Bay
Jake Freimer (5th year student)
Zanet J, et al. Pri sORF peptides induce selective proteasome-mediated protein processing.Science. 2015 Sep 18;349(6254):1356-8. doi: 10.1126/science.aac5677.
Student coachesNone

Friday, October 9, 2015

Stem Cell Journal Club
12:00 p.m. - 1:00 p.m, RMB Boardroom, RMB-1041, Parnassus
Valerie Weaver (faculty)
"Forcing Stemness."
Guo J, et al. Actin stress in cell reprogramming. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5252-61. doi: 10.1073/pnas.1411683111.

Ashley Libby (2nd year student)
"Suck it Up: Endocytosis and Embryonic Wound Repair."
Hunter MV, et al. Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair. J Cell Biol. 2015 Aug 31;210(5):801-16. doi: 10.1083/jcb.201501076.
Coaches: Bruce Conklin and Nancy Boudreau

Wednesday, October 28, 2015

Developmental Biology Journal Club
5:30-6:30 p.m.  Genentech Hall N-114, Mission Bay
Hanna Kirby (2nd year student)
Potts K, et al. Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL. Blood. 2015 Aug 6;126(6):807-16. doi:10.1182/blood-2014-12-616607.

Ying Yang (Postdoc)
Pardo-Saganta A, et al. Parent stem cells can serve as niches for the daughter cells. Nature. 2015 Jul 30;523(7562):597-601: 10.1038/nature14553.

Friday, November 13, 2015

Stem Cell Journal Club
12:00 p.m. - 1:00 p.m, RMB Boardroom, RMB-1041, Parnassus
Akela Kuwahara (2nd year student)
"Collaborative repair of DNA damage between between male and female germ lines."
Lord, T. & Aitken, R. J. Fertilization stimulates 8-hydroxy-2′-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo. Dev. Biol. 406, 1–13 (2015).
Coaches: Canan Doganli and Paolo Rinaudo

Todd Nystul (faculty)
"Turning eukaryotic evolution inside out."
Baum DA & Baum B. An inside-out origin for the eukaryotic cell. BMC Biol. 2014 Oct 28;12:76. doi: 10.1186/s12915-014-0076-2.

Wednesday, November 18, 2015

Developmental Biology Journal Club
5:30-6:30 p.m.  Genentech Hall N-114, Mission Bay 
Lauren Byrnes (1st year student)
Jacob Kimmel (1st year student)

Wednesday, December 9, 2015

Developmental Biology Journal Club
5:30-6:30 p.m.  Genentech Hall N-114, Mission Bay
Melissa Truong (1st year student)
"Let me go!: An E- to N-cadherin switch controls contact inhibition of locomotion in neural crest cells."
Scarpa E, et al. Cadherin switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces. Dev Cell. 2015 Aug 24;34(4):421-34. doi: 10.1016/j.devcel.2015.06.012.
Coach: Ashley Libby

Buddy White (2nd year student)
"The Neuron Nursery"
Sultan S, et al. Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes. Neuron. 2015 Nov 18. pii: S0896-6273(15)00931-9. doi: 10.1016/j.neuron.2015.10.037.
Coach: Liz Wheatley

Friday, January 15, 2016

Stem Cell Journal Club
12:00 p.m. - 1:00 p.m, RMB Boardroom, RMB-1041, Parnassus
Daniel He (2nd year student)
“Flabby chromatin is bad for muscle stem cell maintenance.”
Boonsanay V, et al. Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation. Cell Stem Cell. 2015 Dec 5. pii: S1934-5909(15)00500-7. doi: 10.1016/j.stem.2015.11.002.
Coaches: Daniel Lim and Andrew Brack

Diane Barber (faculty)
"pHascintating pHindings on pH and stem cell behaviors."
Research talk

Wednesday, January 27, 2016

Developmental Biology Journal Club
5:30-6:30 p.m.  Genentech Hall S-261, Mission Bay
Steven Cincotta (1st year student)
"Hissssstones, Enhancersssss, and Divergence of cisssss-Regulatory Element Function During Snake Evolution." 
Infante C, et al. Shared Enhancer Activity in the Limbs and Phallus and Functional Divergence of a Limb-Genital cis-Regulatory Element in Snakes. Dev Cell. 2015 Oct 12;35(1):107-19. doi: 10.1016/j.devcel.2015.09.003. Epub 2015 Oct 1.
Coach: Bonnie Cole

Ashely Libby (2nd year student)
"Are you afraid of the dark? Optogenetic manipulation of morphogenesis."
Guglielmi G, et al. An Optogenetic Method to Modulate Cell Contractility during Tissue Morphogenesis. Dev Cell 35, no. 5 (July 12, 2015): 646–60. doi:10.1016/j.devcel.2015.10.020.
Coaches: Hanna Kirby and Sara Taylor

Friday, February 12, 2016

Stem Cell Journal Club
12:00 p.m. - 1:00 p.m, RMB Boardroom, RMB-1041, Parnassus
Bonnie Cole (2nd year student)
"Ready. Set. Go! A quantitative look into the mechanism of how stem cells choose between epiblast vs. primitive endoderm cell fates."
Schröter C, et al. FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells. Development. 2015 Dec 15;142(24):4205-16. doi: 10.1242/dev.127530.
Coaches: Todd Nystul and Robert Blelloch

Melissa Truong (1st year student)
"FOXO gets the blood pumping: FOXO1 couples metabolic activity and growth state in the vascular endothelium."
Wilhelm K, et al. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature. 2016 Jan 14;529(7585):216-20. doi: 10.1038/nature16498.
Coaches: Rong Wang and Matt Springer

Wednesday, February 24, 2016

Developmental Biology Journal Club
5:30-6:30 p.m.  Genentech Hall N-114, Mission Bay
Nate Meyer (1st year student)
"To Infinity and Beyond: Stem Cells in Space!"
Blaber EA, et al. Microgravity Reduces the Differentiation and Regenerative Potential of Embryonic Stem Cells. Stem Cells Dev. 2015 Nov 15;24(22):2605-21. doi: 10.1089/scd.2015.0218. 
Student Coaches: Ashley Libby and Hanna Kirby

Bonnie Cole (2nd year student)
"TBD: TBX5-NuRD Begets Divide
Waldron L, et al. The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation. Dev Cell. 2016 Feb 8;36(3):262-75. doi: 10.1016/j.devcel.2016.01.009.
Student Coach: Hanna Kirby

Friday, March 4, 2016

Stem Cell Journal Club
12:00 p.m. - 1:00 p.m, Nursing, N-721, Parnassus
Hanna Kirby (2nd year student)
"Time (and Caveolin 1) Heals a Broken Heart."
Cao J, et al. Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration. Development. 2016 Jan 15;143(2):232-43. doi: 10.1242/dev.130534.
Coaches: Daniel Hart and Thea Tlsty

Sarah Knox (faculty)
"Configuring the plumbing: directing progenitor cell movements in the developing kidney."
Riccio P, et al. Ret and Etv4 Promote Directed Movements of Progenitor Cells during Renal Branching Morphogenesis. PLoS Biol. 2016 Feb 19;14(2):e1002382. doi: 10.1371/journal.pbio.1002382.

Friday, March 11, 2016

Stem Cell Journal Club
12:00 p.m. - 1:00 p.m, RMB Boardroom, RMB-1041, Parnassus
Nathaniel Meyer (1st year student)
“Men: Can't Live With 'Em, Can Finally Reproduce Without 'Em.”
Zhou Q, et al. Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro. Cell Stem Cell. 2016 Feb 23. pii: S1934-5909(16)00018-7. doi: 10.1016/j.stem.2016.01.017.
Coaches: Julie Sneddon and Diana Laird

Jacob Kimmel (1st year student)
“Senescent Cells Shorten Healthy Lifespan.”
Baker DJ, et al. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature530, 184–189 (2016).
Coaches: Todd Nystul and Saul Villeda

Wednesday, March 30, 2016

Developmental Biology Journal Club
5:30-6:30 p.m.  Genentech Hall N-114, Mission Bay
Sung Hong (1st year student)
"Astrocytes as Markers of New Neurons?!"
Sultan S, et al. Synaptic Integration of Adult-Born Hippocampal Neurons is locally controlled by Astrocytes. Neuron. 2015 Dec 2;88(5):957-72. doi: 10.1016/j.neuron.2015.10.037.
Student Coach: Ramsey Najm

Daniel He (2nd year student)
“Zika!”
Tang H, et al. Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. 
Cell Stem Cell. 2016 Mar 3. pii: S1934-5909(16)00106-5. doi: 10.1016/j.stem.2016.02.016.

Student Coach: Becky Andersen

Friday, April 8, 2016

Stem Cell Journal Club
12:00 p.m. - 1:00 p.m, RMB Boardroom, RMB-1041, Parnassus
Sung Jun Hong (1st year student)
“iPSCs to model aging? TBD"
Mertens J, et al. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell. 2015 Dec 3;17(6):705-18. doi: 10.1016/j.stem.2015.09.001. Epub 2015 Oct 8. 
Coaches: Saul Villeda and Georgia Panagiotakos

Steven Cincotta (1st year student)
“One step closer to therapeutic cloning."
Chung YG, et al. Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells. Cell Stem Cell. 2015 Dec 3;17(6):758-66. doi: 10.1016/j.stem.2015.10.001. 
Coaches: Robert Blelloch and Jeff Bush

Wednesday, April 27, 2016

Developmental Biology Journal Club
5:30-6:30 p.m.  Genentech Hall N-114, Mission Bay
Arpana Arjun (1st year student)
"Get smart: The unfolded protein response contributes to progenitor specification during corticogenesis"
Laguesse S, et al. A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis. Dev Cell. 2015 Dec 7;35(5):553-67. doi: 10.1016/j.devcel.2015.11.005.
Student Coaches: Ashley Libby and Ramsey Najm

Akela Kuwahara (2nd year student)
"Help a sister out"
Lei L, et al. Mouse oocytes differentiate through organelle enrichment from sister cyst germ cells.Science. 2016 Apr 1;352(6281):95-9. doi: 10.1126/science.aad2156. Epub 2016 Feb 25.
Student Coach: Buddy White

Friday, May 13, 2016

Stem Cell Journal Club
12:00 p.m. - 1:00 p.m, Genentech Hall, Room N114, Mission Bay
Lauren Byrnes (1st year student)
"The way to the pancreas' heart? Through the stomach."
Ariyachet et al. Reprogrammed Stomach Tissue as a Renewable Source of Functional Beta Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 3;18(3):410-21. doi: 10.1016/j.stem.2016.01.003. Epub 2016 Feb 18.
Coaches: Julie Sneddon and Todd Nystul

Arpana Arjun (1st year student)
"Establishing a new in vitro model of ALS."
Liu ML et al. Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients. Cell Rep. 2016 Jan 5;14(1):115-28. doi: 10.1016/j.celrep.2015.12.018. Epub 2015 Dec 24.
Coaches: Michael Oldham and Todd Nystul