DSCB Journal Clubs Archive 2013-14

Wednesday, 9/25/2013    
Developmental Biology Journal Club    

5:30-6:30 p.m., CVRI SC314, Mission Bay    
Jake Freimer (Student, Blelloch Lab)    
Little LC, Tikhonov M, Gregor T. Precise Developmental Gene Expression Arises from Globally Stochastic Transcriptional Activity. Cell - 15 August 2013 (Vol. 154, Issue 4, pp. 789-800).

Friday, 10/11/2013    
Stem Cell Journal Club    

12:00-1:00 p.m., RMB Boardroom #1041, Parnassus    
1) Liz Wheatley (Student, Villeda Lab)    
Wang S, Bates J, Li X, Schanz S, Chandler-Militello D, Levine C, Maherali N, Studer L, Hochedlinger K, Windrem M, Goldman SA.. Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination. Cell Stem Cell. 2013 Feb 7;12(2):252-64. doi: 10.1016/j.stem.2012.12.002. PMID: 23395447 Download
Coaches: Saul Villeda and David Rowitch

2) Todd Nystul (Faculty)
"Okay, but can they think?"
Lancaster MA, Renner M, Martin CA, Wenzel D, Bicknell LS, Hurles ME, Homfray T, Penninger JM, Jackson AP, Knoblich JA. Cerebral organoids model human brain development and microcephaly. Nature. 2013 Sep 19;501(7467):373-9. doi: 10.1038/nature12517. Epub 2013 Aug 28. PMID: 23995685. Download

Wednesday, 10/30/2013  
Developmental Biology Journal Club  
5:30-6:30 p.m.    
CVRI 1st floor Main Conference, Mission Bay    
James Price (First Year Student)  
"Deterministic somatic cell reprogramming: generation of iPS cells with near 100% efficiency"
Rais, Yoach, et al. Deterministic direct reprogramming of somatic cells to pluripotency. Nature 502.7469 (2013): 65-70. Dowload
Student coaches: Becky Andersen and Jake Freimer
Friday, 11/8/2013    
Stem Cell Journal Club   
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus    
1) Andy Norman (Student, Reiter Lab)  
Nakaki F, Hayashi K, Ohta H, Kurimoto K, Yabuta Y, Saitou M. Induction of mouse germ-cell fate by transcription factors in vitro. Nature. 2013 Sep 12;501(7466):222-6. doi:10.1038/nature12417. Epub 2013 Aug 4. PubMed PMID: 23913270. Download
Coaches: Orion Weiner and Jeremy Reiter
2) Elliott Sherr (Faculty)
"Let's Go Crazy"
Han K et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.Nature. 2013 Oct 23. doi: 10.1038/nature12630. [Epub ahead of print] Download

Monday, 11/25/2013   
Developmental Biology Journal Club   
5:30-6:30 p.m., CVRI SC314, Mission Bay    
Brian Yang
(DSCB First Year Student)
"Effects of depletion of p53 in breast cancer cells"
Freed-Pastor, W. et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell 148, 244-258 (2012) Download
Student Coach: Andy Norman   

Friday, 12/6/2013 
Stem Cell Journal Club  
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus    
Matt George (Student, Bruneau Lab)    
Denholtz M et al. Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and polycomb proteins in genome organization. Cell Stem Cell. 2013 Nov 7;13(5):602-16. doi: 10.1016/j.stem.2013.08.013. Epub 2013 Sep 12. Download
Coaches: Benoit Bruneau and Elphege Nora

Trevor Burt (Faculty)
"The Power of Positive Selection: Antigen specificity is the key to generating mature T cells from human iPS cells"
Nishimura TS et al. Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation. Cell Stem Cell. 2013 Jan 3;12(1):114-26. Download

Friday, 1/10/2014    
Stem Cell Journal Club 
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus    
Becky Andersen (Student, Lim Lab)
"Age is not just a number: progerin-induced aging of iPSCs"
Miller JD et al. Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging. Cell Stem Cell. 2013 Dec 5; 13(6): 691-705. Download
Coaches: Daniel Lim and Miguel Ramalho-Santos

Saul Villeda (Faculty)
"Stem Cells and Down Syndrome: Lessons about aging?"
Adorno M. et al. Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature. 2013 Sept 19; 501(7467):380-4 Download

Wednesday, 1/29/2014 
Developmental Biology Journal Club  
5:45 p.m., CVRI 1st floor Main Conference, Mission Bay    
Sara Taylor (First Year Student)    
Storer M et al. Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning. Cell. 2013 Nov 21;155(5):1119-30. Download
Student Coaches: Justin Ellis and Jake Freimer

Friday, 2/14/2014  
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus
Svetlana Keylin (Student, Kajimura Lab)    
“Breaking up is hard to do: mitochondrial fission contributes to brown fat thermogenesis”
Wikstrom J. D et al. (2014). Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure. EMBOJournal. doi:10.1002/embj.201385014
Coaches: Saul Villeda and Shingo Kajimura

Bassem Al-Sady (Faculty)
“How softening  up your nucleus keeps you pluripotent”
Christophorou MA et al. Citrullination regulates pluripotency and histone H1 binding to chromatin. Nature. 2014 Jan 26. doi: 10.1038/nature12942

Developmental Biology Journal Club
Wednesday, February 26, 2014    

5:30-6:30 p.m., CVRI 1st floor Main Conference, Mission Bay    
Christina Abundis
(DSCB First Year Student)
Pauli A et al. Toddler: an embryonic signal that promotes cell movement via Apelin receptors. 
Science. 2014 Feb 14;343(6172):1248636. Download
Student Coaches: Liz Wheatley and Jake Freimer  

Friday, 3/14/2014
Stem Cell Journal Club  
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus   

Mikhail Binnewies (student)
“Put down the Axiron and pick up the estrogen! Your HSCs will thank you.”
Nakada et al. Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy. Nature. 2014 Jan 23;505(7484):555-8 Download
Coaches: Max Krummel and Diana Laird

Emin Maltepe (faculty)
"Sweat the small stuff - Early embryonic environment can affect long term health"
Rexhaj E et al. Mice generated by in vitro fertilization exhibit vascular dysfunction and shortened life span. J Clin Invest. 2013 Dec 2;123(12):5052-60. Download

Wednesday, 3/26/2014  
Developmental Biology Journal Club
5:45 p.m., CVRI 1st floor Main Conference, Mission Bay    
Ramsey Najm (First Year Student)    
Obokata H1, Wakayama T2, Sasai Y3, Kojima K4, Vacanti MP5, Niwa H6, Yamato M7, Vacanti CA4. Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature. 2014 Jan 30;505(7485):641-7. Download
Student coaches: Jake Freimer and Justin Ellis

Friday, 4/11/2014 
Stem Cell Journal Club   
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus    
James Price (First Year Student)
"Timing is key for SCNT"
Faculty Coach: John L. Rubenstein
Kang E, et al. Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos.
Nature. 2014 Mar 26. Download
Brian Yang (First Year Student)
"What gives sympathy to your heart?"
Faculty Coach: Saul Villeda
Nam J, et al. Coronary veins determine the pattern of sympathetic innervation in the developing heart. Development. 2013 Apr;140(7):1475-85. Download

Wednesday, 4/30/2014    
Developmental Biology Journal Club   
5:45 p.m., CVRI 1st floor Main Conference, Mission Bay    
Elijah Martin (First Year Student)
Hudish LI et al. miR-219 Regulates Neural Precursor Differentiation by Direct Inhibition of Apical Par Polarity Proteins.  Dev Cell. 2013 Nov 25;27(4):387-98 Download
Student Coaches: Jake Freimer and Justin Ellis    

Friday, 5/9/2014  
Stem Cell Journal Club
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus   
Sara Taylor (First Year Student)
Faculty Coach: Susan Fisher
Abd Elmageed ZY et al. Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes.
Stem Cells. 2014 Apr;32(4):983-97. Download

Christina Abundis (First Year Student)
"Calcineurin is Essential for Neural Induction" 
Faculty Coach: Rik Derynck
Cho A et al. Calcineurin Signaling Regulates Neural Induction through Antagonizing the BMP Pathway.
Neuron. 2014 Apr; 82:109-24. Download

Wednesday, 5/28/2014 - CANCELLED
Developmental Biology Journal Club 
5:45 p.m., CVRI 1st floor Main Conference, Mission Bay    
Presenter TBD    

Friday, 6/13/2014  
Stem Cell Journal Club   
12:00-1:00 p.m., RMB Boardroom #1041, Parnassus    
Ramsey Najm (First Year Student)
Faculty Coaches: Yadong Huang and Saul Villeda
Talk Title: "Calm Your Glia"
Ziyuan Guo, et al. In Vivo Direct Reprogramming of Reactive Glial
Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model.
Cell Press. 2014 Feb 6;14(2):188-202. Download
Elijah Martin (First Year Student)
Faculty Coach: Marco Conti
Talk Title: "The mysteries of implantation revealed"
Ivan Bedzhov, et al. Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation.
Cell. 2014 Feb 27;156(5):1032-44. Download