DSCB Journal Clubs Archive 2019-20

Friday, September 27, 2019 - 12:00pm - 1:30pm - Room: N-721

Todd Nystul (faculty)
"Know thy surroundings: factors that shape keratinocyte progenitor cell fate"
Box, K., Joyce, B.W., and Devenport, D. (2019). Epithelial geometry regulates spindle orientation and progenitor fate during formation of the mammalian epidermis. Elife 8.

Nicholas Elder (student)
"Putting in the Legwork: An Organoid Model of the Developing Limb Bud."
Mori, S. et al. Self-organized formation of developing appendages from murine pluripotent stem cells. Nat. Commun. 10, 3802 (2019)
Coaches: Alex Pollen and Tien Peng

Wednesday, October 9, 2019 - 5:00pm - 7:00pm - Room: MH-1407

Emily Bulger (student)
"Pesky Pescoids: How 'Self-organized symmetry breaking in zebrafish reveals feedback from morphogenesis to pattern formation'"

Trivedi V, Fulton T, Attardi A, Anlas K, Dingare C, Martinez Arias A, Steventon BJ."Self-organized symmetry breaking in zebrafish reveals feedback from morphogenesis to pattern formation" BioRxiv. 2019 Sept 14. DOI 10.1101/769257

Nicholas Elder (student)
"Shedding some light on signaling dynamics and cell fate in Drosophila"
Johnson, H. E., Shvartsman, S. Y. & Toettcher, J. E. Signaling dynamics control cell fate in the early Drosophila embryo. BioRxiv (2018). doi:10.1101/342998

Friday, October 18, 2019 - 12:00pm - 1:00pm - Room: N-721

Elphege Nora (faculty)
"A symmetric toggle switch explains the onset of random X inactivation in different mammals"
Mutzel et al., A symmetric toggle switch explains the onset of random X inactivation in different mammals. Nature Structural & Molecular Biology volume 26, pages350–360 (2019), doi:10.1038/s41594-019-0214-1

Brandon Chacon (student)
"When they go low, we go high"
Soldatov et al., Spatiotemporal structure of cell fate decisions in murine neural crest.Science  07 Jun 2019: Vol. 364, Issue 6444, eaas9536
Coaches: Faranak Fattahi and Alex Pollen

Wednesday, October 30, 2019 - 5:00pm - 7:00pm - Room: MH-1407

Eliza Gaylord (student)
"Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function."
Mullapudi, S. T., Boezio, G. L. M., Rossi, A., Marass, M., Matsuoka, R. L., Matsuda, H., Helker, C. S. M., Yang, Y. H. C. Stainier, D. Y. R. (2019). Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function. Development, dev.173674.

Brandon Chacon (student)
"Mouse prostates flying through the space-time continuum!"
Elisavet Tika, Marielle Ousset, Anne Dannau, Cédric Blanpain. Spatiotemporal regulation of multipotency during prostate development. Development 2019 146: dev180224 doi: 10.1242/dev.180224 Published 23 October 2019

Friday, November 15, 2019 - 12:00pm - 1:00pm - Room: N-721

Diane Barber (faculty)
"Form supports function: connecting actin dynamics to chromatin remodeling and cell fate reprogramming"
Hu, X., Liu, Z.Z., Chen, X. et al. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Nat Commun 10, 1695 (2019)

Michael Mobaraki (student)
"Overtime Subtle Variability in Transcription and Methylation Arises in Mouse Muscle Stem Cells"
Hernando-Herraez et al., Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells, Nature Communications 2019 Sep 25; 10(1):4361.
Coaches: Robert Blelloch and Alex Pollen

Friday, January 17, 2020 - 12:00pm - 1:00pm - Room: N-721

Sophie Dumont (faculty)
"How mammalian oocytes build a spindle without centrosomes"
Science. 2019 Jun 28;364(6447).
A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.
So C, Seres KB, Steyer AM, Mönnich E, Clift D, Pejkovska A, Möbius W, Schuh M

Matthew Keefe (student)
"Got Developing Spinal Cord Circuitry? Go Fish"
Wan, Y., Wei, Z., Looger, L.L., Koyama, M., Druckmann, S., and Keller, P.J. (2019). Single-Cell Reconstruction of Emerging Population Activity in an Entire Developing Circuit. Cell 179, 355-372.e23.
Coaches: Georgia Panagiotakos and Faranak Fattahi

Wednesday, January 29, 2020 - 5:00pm - 7:00pm - Room: MH-1406

Reed McMullen (student)
"TBD"
Xin Zhu et al,. Cilia-driven asymmetric Hedgehog signalling determines the amphioxus left-right axis by controlling Dand5 expression. Development 2020 147: dev182469 doi: 10.1242/dev.182469 Published 13 January 2020

Michael Mobaraki (student)
"Profiling Protein Changes in Blood Plasma Overtime"
Benoit Lehallier et al,. Undulating changes in human plasma proteome profiles across the lifespan. Nature Medicine volume 25, pages1843–1850(2019).

Wednesday, February 12, 2020 - 5:00pm - 7:00pm - Room: MH-1406

Karissa Hansen (student)
“Bifunctional cis-regulatory elements in Drosophila development"
Gisselbrecht et al. (2020). Transcriptional silencers in Drosophila serve a dual role as transcriptional enhancers in alternate cellular contexts. Mol. Cell, 77: 324-337. https://doi.org/10.1016/j.molcel.2019.10.004

Matthew Keefe (student)
"Tick Tock Around the Segmentation Clock"
Diaz-Cuadros, M., Wagner, D.E., Budjan, C., Hubaud, A., Tarazona, O.A., Donelly, S., Michaut, A., Al Tanoury, Z., Yoshioka-Kobayashi, K., Niino, Y., et al. (2020). In vitro characterization of the human segmentation clock. Nature 1–6.

Friday, February 21, 2020 - 12:00pm - 1:00pm - Room: N-721

Jean Luke Campos (student)
"FGF Signaling Defines Cell Fate Boundaries in the Developing Mouse Jaw"
Roberts, R.R., et al., FGF signaling patterns cell fate at the interface between tendon and bone. Development, 2019. 146(15)
Coaches: Ralph Marcucio and Todd Nystul

Wednesday, March 4, 2020 - 5:00pm - 7:00pm - Room: MH-1406

Alexander Merriman (student)
"LARRY the Clonality Guy"
Weinreb, C. et al. Lineage tracing on transcriptional landscapes links state to fate during differentiation. Science  14 Feb 2020: Vol. 367, Issue 6479, eaaw3381. DOI: 10.1126/science.aaw3381

Jean Luke Campos (student)
"Acquisition of a Unique Mesenchymal Precursor-like Blastema State Underlies Successful Adult Mammalian Digit Tip Regeneration"
Storer, M. et al. Acquisition of a Unique Mesenchymal Precursor-like Blastema State Underlies Successful Adult Mammalian Digit Tip Regeneration. Dev Cell. 2020 Feb 24;52(4):509-524.e9. doi: 10.1016/j.devcel.2019.12.004. 

Friday, March 20, 2020 - 12:00pm - 1:00pm - Room:

Thi Nguyen (student)
"Vertebrate diapause preserves organisms long term through Polycomb complex members"
Hu, Chi-Kuo, et al. "Vertebrate diapause preserves organisms long term through Polycomb complex members." Science 367.6480 (2020): 870-874.
Coaches: Todd Nystul and Guo Huang

Emily Bulger (student)
"Axial patterning in vitro: Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids."
Van den Brink, S.C., Alemany, A., van Batenburg, V. et al. Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids. Nature (2020). https://doi.org/10.1038/s41586-020-2024-3
Faculty coaches: Licia Selleri and Georgia Panagiotankos
Recorded video of the presentations can be found on the DSCB Intranet. MyAccess login is required.

Wednesday, April 1, 2020 - 5:00pm - 7:00pm - Room:

Aris Taychameekiatchai (student)
"Disruption of dmrt1 rescues the all-male phenotype of the cyp19a1a mutant in zebrafish – a novel insight into the roles of aromatase/estrogens in gonadal differentiation and early folliculogenesis"
Kun Wu, Weiyi Song, Zhiwei Zhang, Wei Ge Development 2020 147: dev182758 doi: 10.1242/dev.182758 Published 17 February 2020

Gugene Kang (student)
"Human Primordial Ge​rm​ Cells Are Specified from Lineage-Primed Progenitors."
Chen D, Sun N, Hou L, Kim R, Faith J, Aslanyan M, Tao Y, Zheng Y, Fu J, Liu W, Kellis M, Clark A. Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. Cell Rep. 2019 Dec 24;29(13):4568-4582.e5. doi: 10.1016/j.celrep.2019.11.083. PubMed PMID: 31875561; PubMed Central PMCID: PMC6939677.

Friday, April 17, 2020 - 12:00pm - 1:00pm - Room:

Gugene Kang (student)
"Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse."
Bakken et al., Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse. doi: https://doi.org/10.1101/2020.03.31.016972.
Coaches: Michael Oldham and Alex Pollen

Alexander Merriman (student)
"Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants."
Kvon, E. Z., Zhu, Y., Kelman, G., Novak, C. S., Plajzer-Frick, I., Kato, M., Garvin, T. H., Pham, Q., Harrington, A. N., Hunter, R. D., Godoy, J., Meky, E. M., Akiyama, J. A., Afzal, V., Tran, S., Escande, F., Gilbert-Dussardier, B., Jean-Marçais, N., Hudaiberdiev, S., … Pennacchio, L. A. (2020). Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants. Cell, 180(6), 1262–1271.e15. https://doi.org/10.1016/j.cell.2020.02.031
Coaches: Licia Selleri and Jeff Bush
Recorded video of the presentations can be found on the DSCB Intranet. MyAccess login is required.

Wednesday, April 29, 2020 - 5:00pm-7:00pm - Room:

Thi Nguyen
"Spontaneous emergence of cell-like organization in Xenopus egg extracts"
Cheng et al., 2019 https://science.sciencemag.org/content/366/6465/631.abstract

Friday, May 15, 2020 - 12:00pm - 1:00pm - Room:

Eliza Gaylord (student)
"Organoids Develop Motor Skills: Self-Organizing 3D Human Trunk Neuromuscular Organoids."
Faustino Martins et al., Self-Organizing 3D Human Trunk Neuromuscular Organoids, Cell Stem Cell (2019), https://doi.org/10.1016/j.stem.2019.12.007
Coaches: Faranak Fattahi and Andrew Brack

Reed McMullen (student)
"Scale-ing epithelial organoids"
Yorick Post et al., Snake Venom Gland Organoids, Cell (2020), https://doi.org/10.1016/j.cell.2019.11.038
Coaches: Todd McDevitt and Ophir Klein
Recorded video of the presentations can be found on the DSCB Intranet. MyAccess login is required.

Friday, June 5, 2020 - 12:00pm - 1:00pm - Room:

Aris Taychameekiatchai (student)
"Differences in biosynthetic production define potency hierarchy in colorectal cancer"
Morral et al., Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer, Cell Stem Cell (2020), https://doi.org/10.1016/j.stem.2020.04.012
Coaches: Todd Nystul and Barbara Panning

Karissa Hansen (student)
“Dynamic regulation at the Hoxd locus in the development of external genitalia” 
Amândio, A. R., Lopez-Delisle, L., Bolt, C. C., Mascrez, B., & Duboule, D. (2020). A complex regulatory landscape involved in the development of mammalian external genitals. eLife, 9, e52962. https://doi.org/10.7554/eLife.52962
Coaches: Nadav Ahituv and Yin Shen
Recorded video of the presentations can be found on the DSCB Intranet. MyAccess login is required.