Friday, September 27, 2019 - 12:00pm - 1:30pm - Room: N-721
Todd Nystul (faculty)
"Know thy surroundings: factors that shape keratinocyte progenitor cell fate"
Box, K., Joyce, B.W., and Devenport, D. (2019). Epithelial geometry regulates spindle orientation and progenitor fate during formation of the mammalian epidermis. Elife 8.
Nicholas Elder (student)
"Putting in the Legwork: An Organoid Model of the Developing Limb Bud."
Mori, S. et al. Self-organized formation of developing appendages from murine pluripotent stem cells. Nat. Commun. 10, 3802 (2019)
Coaches: Alex Pollen and Tien Peng
Wednesday, October 9, 2019 - 5:00pm - 7:00pm - Room: MH-1407
Emily Bulger (student)
"Pesky Pescoids: How 'Self-organized symmetry breaking in zebrafish reveals feedback from morphogenesis to pattern formation'"
Trivedi V, Fulton T, Attardi A, Anlas K, Dingare C, Martinez Arias A, Steventon BJ."Self-organized symmetry breaking in zebrafish reveals feedback from morphogenesis to pattern formation" BioRxiv. 2019 Sept 14. DOI 10.1101/769257
Nicholas Elder (student)
"Shedding some light on signaling dynamics and cell fate in Drosophila"
Johnson, H. E., Shvartsman, S. Y. & Toettcher, J. E. Signaling dynamics control cell fate in the early Drosophila embryo. BioRxiv (2018). doi:10.1101/342998
Friday, October 18, 2019 - 12:00pm - 1:00pm - Room: N-721
Elphege Nora (faculty)
"A symmetric toggle switch explains the onset of random X inactivation in different mammals"
Mutzel et al., A symmetric toggle switch explains the onset of random X inactivation in different mammals. Nature Structural & Molecular Biology volume 26, pages350–360 (2019), doi:10.1038/s41594-019-0214-1
Brandon Chacon (student)
"When they go low, we go high"
Soldatov et al., Spatiotemporal structure of cell fate decisions in murine neural crest.Science 07 Jun 2019: Vol. 364, Issue 6444, eaas9536
Coaches: Faranak Fattahi and Alex Pollen
Wednesday, October 30, 2019 - 5:00pm - 7:00pm - Room: MH-1407
Eliza Gaylord (student)
"Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function."
Mullapudi, S. T., Boezio, G. L. M., Rossi, A., Marass, M., Matsuoka, R. L., Matsuda, H., Helker, C. S. M., Yang, Y. H. C. Stainier, D. Y. R. (2019). Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function. Development, dev.173674.
Brandon Chacon (student)
"Mouse prostates flying through the space-time continuum!"
Elisavet Tika, Marielle Ousset, Anne Dannau, Cédric Blanpain. Spatiotemporal regulation of multipotency during prostate development. Development 2019 146: dev180224 doi: 10.1242/dev.180224 Published 23 October 2019
Friday, November 15, 2019 - 12:00pm - 1:00pm - Room: N-721
Diane Barber (faculty)
"Form supports function: connecting actin dynamics to chromatin remodeling and cell fate reprogramming"
Hu, X., Liu, Z.Z., Chen, X. et al. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Nat Commun 10, 1695 (2019)
Michael Mobaraki (student)
"Overtime Subtle Variability in Transcription and Methylation Arises in Mouse Muscle Stem Cells"
Hernando-Herraez et al., Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells, Nature Communications 2019 Sep 25; 10(1):4361.
Coaches: Robert Blelloch and Alex Pollen
Friday, January 17, 2020 - 12:00pm - 1:00pm - Room: N-721
Sophie Dumont (faculty)
"How mammalian oocytes build a spindle without centrosomes"
Science. 2019 Jun 28;364(6447).
A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.
So C, Seres KB, Steyer AM, Mönnich E, Clift D, Pejkovska A, Möbius W, Schuh M
Matthew Keefe (student)
"Got Developing Spinal Cord Circuitry? Go Fish"
Wan, Y., Wei, Z., Looger, L.L., Koyama, M., Druckmann, S., and Keller, P.J. (2019). Single-Cell Reconstruction of Emerging Population Activity in an Entire Developing Circuit. Cell 179, 355-372.e23.
Coaches: Georgia Panagiotakos and Faranak Fattahi
Wednesday, January 29, 2020 - 5:00pm - 7:00pm - Room: MH-1406
Reed McMullen (student)
"TBD"
Xin Zhu et al,. Cilia-driven asymmetric Hedgehog signalling determines the amphioxus left-right axis by controlling Dand5 expression. Development 2020 147: dev182469 doi: 10.1242/dev.182469 Published 13 January 2020
Michael Mobaraki (student)
"Profiling Protein Changes in Blood Plasma Overtime"
Benoit Lehallier et al,. Undulating changes in human plasma proteome profiles across the lifespan. Nature Medicine volume 25, pages1843–1850(2019).
Wednesday, February 12, 2020 - 5:00pm - 7:00pm - Room: MH-1406
Karissa Hansen (student)
“Bifunctional cis-regulatory elements in Drosophila development"
Gisselbrecht et al. (2020). Transcriptional silencers in Drosophila serve a dual role as transcriptional enhancers in alternate cellular contexts. Mol. Cell, 77: 324-337. https://doi.org/10.1016/j.molcel.2019.10.004
Matthew Keefe (student)
"Tick Tock Around the Segmentation Clock"
Diaz-Cuadros, M., Wagner, D.E., Budjan, C., Hubaud, A., Tarazona, O.A., Donelly, S., Michaut, A., Al Tanoury, Z., Yoshioka-Kobayashi, K., Niino, Y., et al. (2020). In vitro characterization of the human segmentation clock. Nature 1–6.
Friday, February 21, 2020 - 12:00pm - 1:00pm - Room: N-721
Jean Luke Campos (student)
"FGF Signaling Defines Cell Fate Boundaries in the Developing Mouse Jaw"
Roberts, R.R., et al., FGF signaling patterns cell fate at the interface between tendon and bone. Development, 2019. 146(15)
Coaches: Ralph Marcucio and Todd Nystul
Wednesday, March 4, 2020 - 5:00pm - 7:00pm - Room: MH-1406
Alexander Merriman (student)
"LARRY the Clonality Guy"
Weinreb, C. et al. Lineage tracing on transcriptional landscapes links state to fate during differentiation. Science 14 Feb 2020: Vol. 367, Issue 6479, eaaw3381. DOI: 10.1126/science.aaw3381
Jean Luke Campos (student)
"Acquisition of a Unique Mesenchymal Precursor-like Blastema State Underlies Successful Adult Mammalian Digit Tip Regeneration"
Storer, M. et al. Acquisition of a Unique Mesenchymal Precursor-like Blastema State Underlies Successful Adult Mammalian Digit Tip Regeneration. Dev Cell. 2020 Feb 24;52(4):509-524.e9. doi: 10.1016/j.devcel.2019.12.004.
Friday, March 20, 2020 - 12:00pm - 1:00pm - Room:
Thi Nguyen (student)
"Vertebrate diapause preserves organisms long term through Polycomb complex members"
Hu, Chi-Kuo, et al. "Vertebrate diapause preserves organisms long term through Polycomb complex members." Science 367.6480 (2020): 870-874.
Coaches: Todd Nystul and Guo Huang
Emily Bulger (student)
"Axial patterning in vitro: Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids."
Van den Brink, S.C., Alemany, A., van Batenburg, V. et al. Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids. Nature (2020). https://doi.org/10.1038/s41586-020-2024-3
Faculty coaches: Licia Selleri and Georgia Panagiotankos
Recorded video of the presentations can be found on the DSCB Intranet. MyAccess login is required.
Wednesday, April 1, 2020 - 5:00pm - 7:00pm - Room:
Aris Taychameekiatchai (student)
"Disruption of dmrt1 rescues the all-male phenotype of the cyp19a1a mutant in zebrafish – a novel insight into the roles of aromatase/estrogens in gonadal differentiation and early folliculogenesis"
Kun Wu, Weiyi Song, Zhiwei Zhang, Wei Ge Development 2020 147: dev182758 doi: 10.1242/dev.182758 Published 17 February 2020
Gugene Kang (student)
"Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors."
Chen D, Sun N, Hou L, Kim R, Faith J, Aslanyan M, Tao Y, Zheng Y, Fu J, Liu W, Kellis M, Clark A. Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. Cell Rep. 2019 Dec 24;29(13):4568-4582.e5. doi: 10.1016/j.celrep.2019.11.083. PubMed PMID: 31875561; PubMed Central PMCID: PMC6939677.
Friday, April 17, 2020 - 12:00pm - 1:00pm - Room:
Gugene Kang (student)
"Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse."
Bakken et al., Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse. doi: https://doi.org/10.1101/2020.03.31.016972.
Coaches: Michael Oldham and Alex Pollen
Alexander Merriman (student)
"Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants."
Kvon, E. Z., Zhu, Y., Kelman, G., Novak, C. S., Plajzer-Frick, I., Kato, M., Garvin, T. H., Pham, Q., Harrington, A. N., Hunter, R. D., Godoy, J., Meky, E. M., Akiyama, J. A., Afzal, V., Tran, S., Escande, F., Gilbert-Dussardier, B., Jean-Marçais, N., Hudaiberdiev, S., … Pennacchio, L. A. (2020). Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants. Cell, 180(6), 1262–1271.e15. https://doi.org/10.1016/j.cell.2020.02.031
Coaches: Licia Selleri and Jeff Bush
Recorded video of the presentations can be found on the DSCB Intranet. MyAccess login is required.
Wednesday, April 29, 2020 - 5:00pm-7:00pm - Room:
Thi Nguyen
"Spontaneous emergence of cell-like organization in Xenopus egg extracts"
Cheng et al., 2019 https://science.sciencemag.org/content/366/6465/631.abstract
Friday, May 15, 2020 - 12:00pm - 1:00pm - Room:
Eliza Gaylord (student)
"Organoids Develop Motor Skills: Self-Organizing 3D Human Trunk Neuromuscular Organoids."
Faustino Martins et al., Self-Organizing 3D Human Trunk Neuromuscular Organoids, Cell Stem Cell (2019), https://doi.org/10.1016/j.stem.2019.12.007
Coaches: Faranak Fattahi and Andrew Brack
Reed McMullen (student)
"Scale-ing epithelial organoids"
Yorick Post et al., Snake Venom Gland Organoids, Cell (2020), https://doi.org/10.1016/j.cell.2019.11.038
Coaches: Todd McDevitt and Ophir Klein
Recorded video of the presentations can be found on the DSCB Intranet. MyAccess login is required.
Friday, June 5, 2020 - 12:00pm - 1:00pm - Room:
Aris Taychameekiatchai (student)
"Differences in biosynthetic production define potency hierarchy in colorectal cancer"
Morral et al., Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer, Cell Stem Cell (2020), https://doi.org/10.1016/j.stem.2020.04.012
Coaches: Todd Nystul and Barbara Panning
Karissa Hansen (student)
“Dynamic regulation at the Hoxd locus in the development of external genitalia”
Amândio, A. R., Lopez-Delisle, L., Bolt, C. C., Mascrez, B., & Duboule, D. (2020). A complex regulatory landscape involved in the development of mammalian external genitals. eLife, 9, e52962. https://doi.org/10.7554/eLife.52962
Coaches: Nadav Ahituv and Yin Shen
Recorded video of the presentations can be found on the DSCB Intranet. MyAccess login is required.